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Total 124 results found since Jan 2013.

Design and rationale of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study
This study details the design of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study – a postauthorization observational study, which is part of the postapproval plan for edoxaban agreed with the European Medicines Agency. Methods The ETNA-AF-Europe study (Clinicaltrials.gov: NCT02944019) is a multicenter, prospective, observational study that enrolled 13 980 patients with atrial fibrillation treated with edoxaban from 852 sites across 10 European countries (Austria, Belgium, Germany, Ireland, Italy, the Netherlands, Portugal, Spain, Switzerland,...
Source: Journal of Cardiovascular Medicine - January 3, 2019 Category: Cardiology Tags: Research articles: Trial design Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain
This study was carried out in accordance with the recommendations of National Animal Welfare Authority, Ireland. The protocol was approved by the Animal Ethical Committee Trinity College Dublin and HPRA.Author ContributionsAS performed the experiments and wrote the paper; KH provided assistance in the design and analysis of the RNAseq experiment; DT contributed to sample extraction and establishment of the colony; and DT and MG designed and supervised all the parts of the research and the writing of the manuscript.FundingThe study was funded by the Wellcome Trust Grant WT079408/C/06/Z issued to MG, and by an SFI FN Funded ...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

207 Acute Incidence of Disease at Elevated Levels of Fine Particulate Matter (PM2.5) in Dublin, Ireland
ConclusionControls need to be brought in to ensure that PM2.5 does not exceed a 50μg/m3 level due to the increase in disease incidence associated with same. The urban burning of solid fuels should be severely restricted.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

268 Can the Swallow Screening Component of a Frailty Assessment be Used to Reliably Direct Clinical Dysphagia Assessment Referrals?
ConclusionA trained interdisciplinary frailty team can reliably screen for and identify risk of dysphagia. This indicates a potential for use of more standardised swallow screening protocols beyond the post stroke population into a broader cohort of patients.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

EP47* Investigation of current and novel treatment strategies for ICA and MCA occlusions in an in-vitro thrombectomy model
ConclusionsThe novel 0.088’’ aspiration catheter achieves the best FPE rates in both ICA and MCA occlusions. In terms of existing techniques, ADAPT is more effective in the MCA, while the stentrievers provide a benefit in the ICA.ReferencesHafeez MU, Kan P, Srivatsan A, Moore S, Jafari M, DeLaGarza C, et al. Comparison of first-pass efficacy among four mechanical thrombectomy techniques: a single-center experience. World Neurosurgery 2020;144:e533–e40.Gershon BS, Bageac DV, Shigematsu T, Majidi S, De Leacy R. Republished: first clinical report of aspiration through a novel 0.088-inch catheter positioned i...
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Nogueira, R., Thornton, J., Mullins, L., Fitzgerald, S. Tags: Treatment Source Type: research

Osteoporotic fracture admissions compared to other major medical admissions in Irish public hospitals
ConclusionOsteoporotic fractures represent a large and rapidly increasing illness burden amongst older Irish adults, with substantial care requirements and the resulting onus on our healthcare system. Urgent action is needed to address this public health issue and the services for those at risk of fracture.
Source: Archives of Orthopaedic and Trauma Surgery - December 17, 2022 Category: Orthopaedics Source Type: research

The association of cold weather and all-cause and cause-specific mortality in the island of Ireland between 1984 and 2007
Conclusions: The study findings indicated strong cold weather-mortality associations in the island of Ireland; these effects were less persistent, and for CVD mortality, smaller in NI than in the ROI. Together with suggestive differences in associations by age and gender between the two Irish jurisdictions, the findings suggest potential contribution of underlying societal differences, and require further exploration. The evidence provided here will hope to contribute to the current efforts to modify fuel policy and reduce winter mortality in Ireland.
Source: BioMed Central - December 6, 2014 Category: Journals (General) Authors: Ariana ZekaStephen BrowneHelen McAvoyPatrick Goodman Source Type: research

When should a doctor see me when I get sick? A study of the time of day acutely ill medical patients present and the time they wait to see a doctor in Ireland.
CONCLUSION: Waiting to be seen by a doctor may increase the risk of death to some patients. For these patients it is probably safer to be seen quickly by any doctor, rather than travel many miles and wait several hours to see a better one. PMID: 25468249 [PubMed - in process]
Source: European Journal of Internal Medicine - December 1, 2014 Category: Internal Medicine Authors: Kellett J, Deane B Tags: Eur J Intern Med Source Type: research

Peripheral Artery Disease: A Marked Lack of Awareness in Ireland.
CONCLUSIONS: This study demonstrates a disturbing lack of awareness of PAD and highlight the need for a meaningful targeted public health awareness campaign on PAD in order to close the gap of knowledge in Irish patients, prior to any prevention campaign. PMID: 25736513 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - February 28, 2015 Category: Surgery Authors: Cronin CT, McCartan DP, McMonagle M, Cross KS, Dowdall JF Tags: Eur J Vasc Endovasc Surg Source Type: research

FDA approves Malin ’ s Hourglass peripheral embolization plug
Irish life sciences company Malin Corp said today it won FDA 510(k) clearance for its Hourglass peripheral embolization plug. The company said the Hourglass plug is designed to be deployed over-the-wire for peripheral embolization procedures, and can provide immediate occlusion with a single integrated device. “This is the 1st integrated, over-the-wire device designed for peripheral embolization procedures. The goal with over-the-wire design is to provide physicians with accurate, stent-like delivery of the device in the vessel,” Hourglass co-developer George Wallace, said in prepared remarks. “The Hourgl...
Source: Mass Device - August 22, 2017 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Regulatory/Compliance Vascular malincorp Source Type: news

Exploring functional outcomes and allied health staffing levels in an inpatient paediatric rehabilitation unit.
CONCLUSIONS: This review from a tertiary hospital-based inpatient paediatric rehabilitation service provides information regarding the length of stay, functional change and allied health workload for children and adolescents on active inpatient rehabilitation programs. As expected, total and rehabilitation episode length of stay, functional improvement and allied health contact and input varied according to diagnostic groups. This information is likely to be of value to other Paediatric Rehabilitation Medicine inpatient units when developing staffing for services and benchmarking service delivery. Implications for Rehabili...
Source: Disability and Rehabilitation - October 10, 2017 Category: Rehabilitation Authors: Ireland PJ, Francis A, Jackman S, McLennan K Tags: Disabil Rehabil Source Type: research

Associations between Ambient Fine Particulate Oxidative Potential and Cardiorespiratory Emergency Department Visits
Conclusions: Lag 0–2 OPDTT was associated with ED visits for multiple cardiorespiratory outcomes, providing support for the utility of OPDTT as a measure of fine particle toxicity. https://doi.org/10.1289/EHP1545 Received: 23 December 2016 Revised: 4 August 2017 Accepted: 12 August 2017 Published: 26 October 2017 Please address correspondence to J.Y. Abrams, Centers for Disease Control and Prevention, NCEZID/DHCPP, 1600 Clifton Rd. NE, CDC Mailstop A30, Atlanta, GA 30333 USA. Telephone: (404) 639-5121. Email: jabrams@cdc.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1545). The authors ...
Source: EHP Research - October 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Dietary patterns and retinal vessel caliber in the Irish Nun Eye Study
ConclusionIn this cohort of older women with a restricted lifestyle, an unhealthy DP was independently associated with an unfavorable retinal profile, namely a widening of retinal venules and narrowing of retinal arterioles. Key words: Dietary
Source: The Journal of Nutrition, Health and Aging - December 5, 2017 Category: Nutrition Source Type: research