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Procedure: Anesthesia

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Total 123 results found since Jan 2013.

Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels
Conclusions and ImplicationsEugenol activates TRPV4 channels in mesenteric artery endothelial cells, leading to vasorelaxation, and reduces systemic BP in vivo. Eugenol may be therapeutically useful as an antihypertensive agent and is a viable molecular candidate from which to develop second‐generation TRPV4 channel activators that reduce BP.
Source: British Journal of Pharmacology - May 19, 2015 Category: Drugs & Pharmacology Authors: Dieniffer Peixoto‐Neves, Qian Wang, Jose H Leal‐Cardoso, Luciana V Rossoni, Jonathan H Jaggar Tags: RESEARCH PAPER Source Type: research

Ketamine promotes inflammation through increasing TLR4 expression in RAW264.7 cells
In conclusion, KTM accelerated LPS-induced inflammation in RAW264.7 cells by promoting TLR4 expression, independent of NMDA receptor.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 1, 2015 Category: Research Source Type: research

Elevation of Sestrin-2 expression attenuates Sevoflurane induced neurotoxicity
In this study, our results indicated that administration of Sevoflurane elevated the gene and protein expression of Sestrin-2 in a dose dependent manner in human neuroblastoma M17 cells. It was shown that silence of Sestrin-2 by small RNA interference (siRNA) ominously exacerbated the increase in intracellular ROS and reduction of SOD activity induced by Sevoflurane treatment. Notably, knockdown of Sestrin-2 in M17 cells significantly increases the number of apoptotic cells after treatment with Sevoflurane. Mechanistically, we also found that Sevoflurane treatment resulted in a reduced amount of the cytosolic anti-apoptoti...
Source: Metabolic Brain Disease - September 5, 2015 Category: Neurology Source Type: research

MeCP2 and Nerve Injury
Conclusions: The study shows a regulatory role for MeCP2 in that changes in global redistribution can result in direct and indirect modulation of gene expression in the DRG. Alterations in genome-wide binding of MeCP2 therefore provide a molecular basis for a better understanding of epigenetic regulation-induced molecular changes underlying nerve injury.
Source: Neuromics - June 20, 2016 Category: Neuroscience Tags: Delivering siRNA to the CNS epigenetics gene expression analysis i-Fect MECP2 methyl-CpG-binding protein 2 miR-126 Nerve Injury Nerve Sprouting Source Type: news

i-Fect used to Study Epigenetics in Nerve Injury
Conclusions: The study shows a regulatory role for MeCP2 in that changes in global redistribution can result in direct and indirect modulation of gene expression in the DRG. Alterations in genome-wide binding of MeCP2 therefore provide a molecular basis for a better understanding of epigenetic regulation-induced molecular changes underlying nerve injury.
Source: siRNA and DsiRNA Transfection Efficiency - June 20, 2016 Category: Neuroscience Tags: i-Fect MeCP2 Methyl-CpG-binding protein 2 miR-126 miRNA Delivery Methods Nerve Injury. Source Type: news

Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
Abstract The local anaesthetics (LAs) are widely used for peripheral nerve blocks, epidural anaesthesia, spinal anaesthesia and pain management. However, exposure to LAs for long duration or at high dosage can provoke potential neuronal damages. Autophagy is an intracellular bulk degradation process for proteins and organelles. However, both the effects of LAs on autophagy in neuronal cells and the effects of autophagy on LAs neurotoxicity are not clear. To answer these questions, both lipid LAs (procaine and tetracaine) and amide LAs (bupivacaine, lidocaine and ropivacaine) were administrated to human neuroblastoma SH‐S...
Source: Journal of Cellular and Molecular Medicine - October 31, 2016 Category: Molecular Biology Authors: Jingwei Xiong, Qiuyue Kong, Leyang Dai, He Ma, Xiaofei Cao, Li Liu, Zhengnian Ding Tags: Original Article Source Type: research

Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity.
Abstract The local anaesthetics (LAs) are widely used for peripheral nerve blocks, epidural anaesthesia, spinal anaesthesia and pain management. However, exposure to LAs for long duration or at high dosage can provoke potential neuronal damages. Autophagy is an intracellular bulk degradation process for proteins and organelles. However, both the effects of LAs on autophagy in neuronal cells and the effects of autophagy on LAs neurotoxicity are not clear. To answer these questions, both lipid LAs (procaine and tetracaine) and amide LAs (bupivacaine, lidocaine and ropivacaine) were administrated to human neuroblasto...
Source: J Cell Mol Med - November 14, 2016 Category: Molecular Biology Authors: Xiong J, Kong Q, Dai L, Ma H, Cao X, Liu L, Ding Z Tags: J Cell Mol Med Source Type: research

Propofol inhibits invasion and growth of ovarian cancer cells via regulating miR-9/NF- κB signal.
Propofol inhibits invasion and growth of ovarian cancer cells via regulating miR-9/NF-κB signal. Braz J Med Biol Res. 2016 Dec 12;49(12):e5717 Authors: Huang X, Teng Y, Yang H, Ma J Abstract Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. A previous study has found that propofol can inhibit invasion and induce apoptosis of ovarian cancer cells. However, the underlying mechanisms are not known. miR-9 has been reported to be little expressed in ovarian cancer cells, which has been related to a poor prognosis in patients with ovarian cancer. Studie...
Source: Brazilian Journal of Medical and Biological Research - December 17, 2016 Category: Research Tags: Braz J Med Biol Res Source Type: research

Minocycline attenuates sevoflurane-induced cell  injury via activation of Nrf2.
Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. Int J Mol Med. 2017 Feb 28;: Authors: Tian Y, Wu X, Guo S, Ma L, Huang W, Zhao X Abstract Minocycline has been demonstrated to exert neuroprotective effects in various experimental models. In the present study, we investigated the mechanisms underlying the protective effects of minocycline on cell injury induced by the inhalation of the anesthetic, sevoflurane. In our in vivo experiments using rats, minocycline attenuated sevoflurane-induced neuronal degeneration and apoptosis in the rat hippocampus, and this effect was a...
Source: International Journal of Molecular Medicine - February 27, 2017 Category: Molecular Biology Authors: Tian Y, Wu X, Guo S, Ma L, Huang W, Zhao X Tags: Int J Mol Med Source Type: research

Neuroprotective effect of miR-665 against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway by targeting insulin-like growth factor 2.
This study suggests that miR-665 might be explored as a potential target of therapy for sevoflurane-induced cognitive impairment. PMID: 28386360 [PubMed]
Source: American Journal of Translational Research - April 9, 2017 Category: Research Tags: Am J Transl Res Source Type: research

PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication.
Abstract Activation of PI3K/Akt signaling, leading to upregulation of nitric oxide synthase II (NOS II)/peroxynitrite cascade in the rostral ventrolateral medulla (RVLM), the brain stem site that maintains blood pressure and sympathetic vasomotor tone, underpins cardiovascular depression induced by the organophosphate pesticide mevinphos. By exhibiting dual-specificity protein- and lipid-phosphatase activity, phosphatase and tensin homolog (PTEN) directly antagonizes the PI3K/Akt signaling by dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate, the lipid product of PI3K. Based on the guiding hypothesis t...
Source: Neuropharmacology - June 7, 2017 Category: Drugs & Pharmacology Authors: Tsai CY, Wu JCC, Fang C, Chang AYW Tags: Neuropharmacology Source Type: research

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

Protective role of LRRC3B in preventing breast cancer metastasis and recurrence post-bupivacaine.
Authors: Li GS, Kong GY, Zou Y Abstract The present study aimed to investigate the potential effect of leucine-rich repeat containing 3B (LRRC3B) with respect to the inhibition of breast cancer recurrence and metastasis post-anesthesia. The mRNA expression of LRRC3B in breast MDA-MB-231 and MCF-7 cell lines was detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. The effect of bupivacaine on breast cancer cell invasion was analyzed using a Matrigel assay. LRRC3B specific small interfering (si)RNA was constructed and transfected into breast cancer cells using Lipofectamine(...
Source: Oncology Letters - November 2, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats.
CONCLUSION: As our study provides in vitro and in vivo evidence that hispidulin can offer protection against sevoflurane-induced neurological dysfunction, hispidulin has the potential to be a neuroprotective agent that can improve the cognitive and memory function of elderly patients undergoing anesthesia. PMID: 29091891 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 27, 2017 Category: Drugs & Pharmacology Authors: Huang L, Huang K, Ning H Tags: Biomed Pharmacother Source Type: research

Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation.
This article is protected by copyright. All rights reserved. PMID: 29388230 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - January 31, 2018 Category: Physiology Authors: Seven YB, Perim RR, Hobson OR, Simon AK, Tadjalli A, Mitchell GS Tags: J Physiol Source Type: research