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Nutrition: Copper

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Total 25 results found since Jan 2013.

Effective Delivery of siRNA-Loaded Nanoparticles for Overcoming Oxaliplatin Resistance in Colorectal Cancer
Chemotherapy resistance represents a formidable obstacle in advanced or metastatic colorectal cancer (CRC) patients. It is reported that ATPase copper transporting alpha (ATP7A) plays an important role in chemotherapy resistance in CRC. Here, we identified ATP7A as a potentially key gene of OXA resistance in CRC. The patients with higher expression of ATP7A tended to have platinum drug resistance. While the lower expression of ATP7A by siRNA knockdown resulted in enhancement of OXA sensitivity and increased OXA-induced apoptosis. Further, we demonstrated a novel and safe strategy to increase CRC chemosensitivity by deliver...
Source: Frontiers in Oncology - February 21, 2022 Category: Cancer & Oncology Source Type: research

Silencing of proinflammatory NF- κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA
Nanoscale Adv. 2022 Sep 5;4(21):4502-4516. doi: 10.1039/d2na00250g. eCollection 2022 Oct 25.ABSTRACTAzide-terminated ultrasmall gold nanoparticles (2 nm gold core) were covalently functionalized with alkyne-terminated small-interfering siRNA duplexes by copper-catalyzed azide-alkyne cycloaddition (CuAAC; click chemistry). The nanoparticle core was visualized by transmission electron microscopy. The number of attached siRNA molecules per nanoparticle was determined by a combination of atomic absorption spectroscopy (AAS; for gold) and UV-Vis spectroscopy (for siRNA). Each nanoparticle carried between 6 and 10 siRNA duplex m...
Source: Herpes - November 7, 2022 Category: Infectious Diseases Authors: Natalie Wolff Sebastian Kollenda Kai Klein Kateryna Loza Marc Heggen Leonie Brochhagen Oliver Witzke Adalbert Krawczyk Ingrid Hilger Matthias Epple Source Type: research

Copper Transporter ATP7A Interacts with IQGAP1, a Rac1 Binding Scaffold Protein: Role in PDGF-induced VSMC Migration and Vascular Remodeling.
Abstract Vascular smooth muscle cell (VSMC) migration contributes to neointimal formation after vascular injury. We previously demonstrated that copper (Cu) transporter ATP7A is involved in PDGF-induced VSMC migration in Cu- and Rac1-dependent manner. Underlying mechanism is still unknown. Here we show that ATP7A interacts with IQGAP1, a Rac1- and receptor tyrosine kinase-binding scaffold proteins, which mediates PDGF-induced VSMC migration and vascular remodeling. In cultured rat aortic SMCs, PDGF stimulation rapidly promoted ATP7A association with IQGAP1 and Rac1, and their translocation to lipid rafts and leadi...
Source: Am J Physiol Cell Ph... - September 26, 2018 Category: Cytology Authors: Ashino T, Kohno T, Sudhahar V, Ash D, Ushio-Fukai M, Fukai T Tags: Am J Physiol Cell Physiol Source Type: research

The Antiviral Role of Zinc and Metallothioneins in Hepatitis C Infection
This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - December 1, 2017 Category: Infectious Diseases Authors: Scott A Read, Grant Parnell, David Booth, Mark W Douglas, Jacob George, Golo Ahlenstiel Tags: Original Paper Source Type: research

Dopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta.
Abstract Dopamine beta-hydroxylase (DβH) plays a key role in the synthesis of catecholamines (CAs) in the neuroendocrine regulatory network. The DβH gene was identified from the razor clam Sinonovacula constricta and referred to as ScDβH. The ScDβH gene is a copper type II ascorbate-dependent monooxygenase with a DOMON domain and two Cu2_monooxygen domains. ScDβH transcript expression was abundant in liver and hemolymph. During early development, ScDβH expression significantly increased at the umbo larval stage. Furthermore, the inhibitors and siRNA of DβH were screened. After challenge with DβH inhibitor,...
Source: Gene - January 28, 2020 Category: Genetics & Stem Cells Authors: Li Z, Niu D, Peng M, Xiong Y, Ji J, Dong Z, Li J Tags: Gene Source Type: research

Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells.
Abstract The interest in organic-inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is responsible for regulating antioxidant and phase II xenobiotic enzymes, in vascular endothelial cells. The copper complex rapidly accumulated within cells and induced nuclear translocation of Nrf2, leading to upregulation of the expression of downstream proteins without cytotoxic effects. H...
Source: Journal of Biological Inorganic Chemistry : JBIC - January 29, 2016 Category: Chemistry Authors: Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, Yamamoto C, Kumagai Y, Naka H, Kaji T Tags: J Biol Inorg Chem Source Type: research

Curcumin is a biologically active copper chelator with antitumor activity
Conclusions This study therefore demonstrates curcumin antitumor effect to its copper chelation capability. These results also implicate copper chelation as a general mechanism for their action of some biologically active polyphenols like flavonoids. Graphical abstract
Source: Phytomedicine - February 14, 2016 Category: Drugs & Pharmacology Source Type: research

Featured Article: Effect of copper on nuclear translocation of copper chaperone for superoxide dismutase-1
This study thus demonstrates that under hypoxia condition, both copper and CCS-1 are transported to the nucleus. The nuclear translocation of CCS-1 is copper dependent, but the nuclear translocation of copper could take place alternatively in a CCS-1-independent pathway.
Source: Experimental Biology and Medicine - July 28, 2016 Category: Research Authors: Wang, L., Ge, Y., Kang, Y. J. Tags: IEBMC papers Source Type: research

Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in labrador retrievers
In this study, two cellular copper metabolism proteins, Cu/Zn superoxide dismutase (SOD1) and its chaperone (copper chaperone for SOD1, CCS) were measured in erythrocytes and tested for association with hepatic copper concentrations in 15 Labrador retrievers with normal or increased hepatic copper concentrations. Antibodies against CCS and SOD1 were applicable for use in canine specimens. This was demonstrated by the loss of immune-reactive bands for CCS and SOD1 in siRNA treated canine bile duct epithelial cells. Erythrocyte CCS and CCS/SOD1 ratios were decreased 2.37 (P < 0.001) and 3.29 (P < 0.001) fold in...
Source: The Veterinary Journal - October 25, 2016 Category: Veterinary Research Source Type: research

Role of Prion protein in premature senescence of human fibroblasts
Publication date: Available online 8 August 2017 Source:Mechanisms of Ageing and Development Author(s): Emmanuelle Boilan, Virginie Winant, Elise Dumortier, Benaissa ElMoualij, Pascale Quatresooz, Heinz D. Osiewacz, Florence Debacq-Chainiaux, Olivier Toussaint Prion protein (PrP) is essentially known for its capacity to induce neurodegenerative prion diseases in mammals caused by a conformational change in its normal cellular isoform (PrPC) into an infectious and disease-associated misfolded form, called scrapie isoform (PrPSc). Although its sequence is highly conserved, less information is available on its physiological ...
Source: Mechanisms of Ageing and Development - August 9, 2017 Category: Geriatrics Source Type: research

Cytochrome b561, Copper, β-Cleaved Amyloid Precursor Protein and Niemann-Pick C1 Protein are Involved in Ascorbate-Induced Release and Membrane Penetration of Heparan Sulfate from Endosomal S-Nitrosylated Glypican-1.
Abstract Ascorbate-induced release of heparan sulfate from S-nitrosylated heparan sulfate proteoglycan glypican-1 takes place in endosomes. Heparan sulfate penetrates the membrane and is transported to the nucleus. This process is dependent on copper and on expression and processing of the amyloid precursor protein. It remains unclear how exogenously supplied ascorbate can generate HS-anMan in endosomes and how passage through the membrane is facilitated. Here we have examined wild-type, Alzheimer Tg2576 and amyloid precursor protein (-/-) mouse fibroblasts and human fetal and Niemann-Pick C1 fibroblasts by using ...
Source: Experimental Cell Research - September 9, 2017 Category: Cytology Authors: Cheng F, Fransson LÅ, Mani K Tags: Exp Cell Res Source Type: research

The Involvement of Cytochrome c Oxidase in Mitochondrial Fusion in Primary Cultures of Neonatal Rat Cardiomyocytes.
This study thus demonstrates that copper-dependent CCO is critical for mitochondrial fusion in the regression of cardiomyocyte hypertrophy. PMID: 29396798 [PubMed - as supplied by publisher]
Source: Cardiovascular Toxicology - February 2, 2018 Category: Cardiology Authors: Yin W, Li R, Feng X, James Kang Y Tags: Cardiovasc Toxicol Source Type: research

Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer.
Abstract Autophagy, a cellular survival mechanism, is thought to allow the recycling of cellular breakdown products when cancer cells are subjected to chemotherapy, thus decreasing drug-induced apoptosis. Disulfiram (DSF), a drug widely used to control alcoholism, possesses anticancer activity by inducing apoptosis in vitro and in vivo in a copper (Cu)-dependent manner. Our previous studies proved that DSF/Cu exerts increased anti-tumor effects on non-small cell lung cancer (NSCLC) xenograft models, and inhibits NSCLC recurrence driven by ALDH-positive cancer stem cells. The present study is designed to investigat...
Source: European Journal of Pharmacology - March 13, 2018 Category: Drugs & Pharmacology Authors: Wu X, Xue X, Wang L, Wang W, Han J, Sun X, Zhang H, Liu Y, Che X, Yang J, Wu C Tags: Eur J Pharmacol Source Type: research

Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria
Heterozygosity for Hemoglobin (Hb) S, sickle cell trait (SCT), affects over 40 million people and confers resistance to severe infection by Plasmodium falciparum. Homozygosity for HbS, or compound heterozygosity with certain other alleles of Hb, affects over 4 million individuals and causes sickle cell disease (SCD). Hemolytic anaemia is a prominent feature of SCD and is mainly extravascular, mediated by hepatic and splenic macrophages. No ligands for this process have been identified. As many macrophage phagocytic receptors recognise carbohydrates, we surveyed surface glycan expression by sickle cells using a panel of 8 l...
Source: Blood - November 21, 2018 Category: Hematology Authors: Cao, H., Wassall, H. J., Forrester, M. A., Hall, L. S., Wilson, H. M., Shepherd, J., Patel, B., Masson, A., Henderson, S., Konieczny, G., Beverly, M., Tampakis, D., Antonopoulos, A., Haslam, S. M., Dell, A., Rowe, A. J., Brewin, J., Rees, D. C., Barker, R Tags: 113. Hemoglobinopathies, Excluding Thalassemia-Basic and Translational Science: Poster III Source Type: research