Aging Fits the Disease Criteria of the International Classification of Diseases
Publication date: Available online 3 April 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Khaltourina Daria, Matveyev Yuri, Alekseev Aleksey, Cortese Franco, Ioviţă Anca (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - April 5, 2020 Category: Geriatrics Source Type: research

Editorial Board
Publication date: April 2020Source: Mechanisms of Ageing and Development, Volume 187Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 30, 2020 Category: Geriatrics Source Type: research

Oncogene-induced senescence: From biology to therapy
Publication date: April 2020Source: Mechanisms of Ageing and Development, Volume 187Author(s): Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 19, 2020 Category: Geriatrics Source Type: research

Glutamine-stimulated in vitro hypertrophy is preserved in muscle cells from older women
Publication date: Available online 3 March 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Thomas Chaillou, Igor Sanna, Fawzi Kadi (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 5, 2020 Category: Geriatrics Source Type: research

Quantitative Proteomics to Study Aging in Rabbit Liver
Publication date: Available online 29 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Bushra Amin, Katarena I. Ford, Renã A.S. Robinson (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 1, 2020 Category: Geriatrics Source Type: research

Frailty—A promising concept to evaluate disease vulnerability
Publication date: April 2020Source: Mechanisms of Ageing and Development, Volume 187Author(s): Ana Rita Ribeiro, Susan E. Howlett, Adelaide Fernandes (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 28, 2020 Category: Geriatrics Source Type: research

Editorial Board
Publication date: March 2020Source: Mechanisms of Ageing and Development, Volume 186Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 24, 2020 Category: Geriatrics Source Type: research

Frailty – A promising concept to evaluate disease vulnerability
We describe how high levels of frailty in such disorders predict worse outcomes and play a direct role in disease progression and in prognostic prediction. Overall, the potential for frailty to predict adverse health outcomes among young people as well as in non-age-related diseases is an evolving topic. Understanding how frailty contributes to poor health and how it can be modified to prevent or delay disease progression will ultimately enhance quality of life in affected individuals. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 22, 2020 Category: Geriatrics Source Type: research

SIRT1 and aging related signaling pathways
Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Cui Chen, Min Zhou, Yuchen Ge, Xiaobo WangAbstractAging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD+-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1...
Source: Mechanisms of Ageing and Development - February 19, 2020 Category: Geriatrics Source Type: research

Regulation and roles of mitophagy at synapses
Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Konstantinos Palikaras, Nektarios TavernarakisAbstractMaintenance of synaptic homeostasis is a challenging task, due to the intricate spatial organization and intense activity of synapses. Typically, synapses are located far away from the neuronal cell body, where they orchestrate neuronal signalling and communication, through neurotransmitter release. Stationary mitochondria provide energy required for synaptic vesicle cycling, and preserve ionic balance by buffering intercellular calcium at synapses. Thus, synaptic h...
Source: Mechanisms of Ageing and Development - February 19, 2020 Category: Geriatrics Source Type: research

Corrigendum to “Endurance training improves plasma superoxide dismutase activity in healthy elderly” [Mechanisms of Ageing and Development 185 (2020) 111190]
Publication date: Available online 17 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Roberta Ceci, Guglielmo Duranti, Ester Sara Di Filippo, Danilo Bondi, Vittore Verratti, Christian Doria, Daniela Caporossi, Stefania Sabatini, Ivan Dimauro, Tiziana Pietrangelo (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 18, 2020 Category: Geriatrics Source Type: research

Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats
Publication date: Available online 4 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Vitor Rosetto Muñoz, Rafael Calais Gaspar, Marcos Vinicius Esteca, Igor Luchini Baptista, Renan Fudoli Lins Vieira, Adelino Sanchez Ramos da Silva, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo PauliAbstractThe physical exercise is a potential strategy to control age-related metabolic disorders, such as insulin resistance, impaired glucose homeostasis, and type 2 diabetes. Rho-kinase (ROCK) increases skeletal muscle glucose uptake through Insulin Receptor Substrate 1 ...
Source: Mechanisms of Ageing and Development - February 5, 2020 Category: Geriatrics Source Type: research

Mitochondrial fission and fusion: a dynamic role in aging and potential target for age-related disease
Publication date: Available online 1 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. HoutkooperAbstractThe mitochondria is the major hub to convert energy for cellular processes. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related diseases. Crucial to mitochondrial regulation is the dynamic nature of their network structure. Mitochondria separate and merge using fission and fusion processes in response to change...
Source: Mechanisms of Ageing and Development - February 1, 2020 Category: Geriatrics Source Type: research

Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina
Publication date: Available online 30 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Vanessa Henkel, Lea Schürmanns, Miriam Brunner, Andrea Hamann, Heinz D. OsiewaczAbstractSorting nexins are a conserved protein family involved in vesicle transport, membrane trafficking and protein sorting. The sorting nexin ATG24/SNX4 has been demonstrated to be involved in different autophagy pathways and in endosomal trafficking. However, its impact on cellular quality control and on aging and development is still elusive. Here we report studies analyzing the function of PaATG24 in the aging model Podospora anse...
Source: Mechanisms of Ageing and Development - January 31, 2020 Category: Geriatrics Source Type: research

Molecular mechanisms in Cognitive Frailty: potential therapeutic targets for oxygen-ozone treatment
Publication date: Available online 23 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Catia Scassellati, Miriam Ciani, Antonio Carlo Galoforo, Roberta Zanardini, Cristian Bonvicini, Cristina GeroldiAbstractIn the last decade, cognitive frailty has gained great attention from the scientific community. It is characterized by high inflammation and oxidant state, endocrine and metabolic alterations, mitochondria dysfunctions and slowdown in regenerative processes and immune system, with a complex and multifactorial aetiology. Although several treatments are available, challenges regarding the efficacy and th...
Source: Mechanisms of Ageing and Development - January 24, 2020 Category: Geriatrics Source Type: research

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease
Publication date: Available online 15 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Pratishtha Chatterjee, Malika Fernando, Binosha Fenando, Cintia B Dias, Tejal Shah, Renuka Silva, Shehan Williams, Steve Pedrini, Heidi Hillebrandt, Kathryn Goozee, Edward Barin, Hamid R Sohrabi, Manohar Garg, Stephen Cunnane, Ralph N MartinsAbstractAlzheimer’s disease (AD) is the most common form of dementia. Currently, there is no effective medication for the prevention or treatment of AD. This has led to the search for alternative therapeutic strategies. Coconut oil(CO) has a unique fatty acid composition that ...
Source: Mechanisms of Ageing and Development - January 15, 2020 Category: Geriatrics Source Type: research

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
Publication date: Available online 15 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Brian C. Gilmour, Ruben Gudmundsrud, Johannes Frank, Amund Hov, Sofie Hindkjær Lautrup, Yahyah Aman, Helge Røsjø, Charles Brenner, Mathias Ziegler, Ole-Bjørn Tysnes, Charalampos Tzoulis, Torbjørn Omland, Arne Søraas, Trygve Holmøy, Linda H. Bergersen, Jon Storm-Mathisen, Hilde Nilsen, Evandro F. FangAbstractNicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, an...
Source: Mechanisms of Ageing and Development - January 15, 2020 Category: Geriatrics Source Type: research

Mitophagy and DNA Damage Signaling in Human Aging
Publication date: Available online 7 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Mansi Babbar, Sambuddha Basu, Beimeng Yang, Deborah L. Croteau, Vilhelm A. BohrAbstractAging is associated with multiple human pathologies. In the past few years mitochondrial homeostasis has been well corelated with age-related disorders and longevity. Mitochondrial homeostasis involves generation, biogenesis and removal of dysfunctional mitochondria via mitophagy. Mitophagy is regulated by various mitochondrial and extra-mitochondrial factors including morphology, oxidative stress and DNA damage. For decades, DNA damag...
Source: Mechanisms of Ageing and Development - January 9, 2020 Category: Geriatrics Source Type: research

Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines
Publication date: Available online 2 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Zeinab Farhadi, Mohammad Khaksari, Hossein Azizian, Shahriar Dabiri, Hossein Fallah, Masoumeh NozariAbstractAging causes changes in body composition and energy balance. Estrogen plays an important role in body’s metabolism. The aim of this study was to determine whether estrogen has beneficial effects on leptin responsiveness in aged mice. Young 4 months and aged 19-21 female mice fed High Fat Diet (HFD) or Standard Diet (SD) for 12 weeks and following received estrogen for 4 weeks. Responsiveness to leptin was com...
Source: Mechanisms of Ageing and Development - January 3, 2020 Category: Geriatrics Source Type: research

AISA can control the inflammatory facet of SASP
Publication date: Available online 2 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Patrizia A. d’Alessio, Marie C. BénéAbstractSenescent cells have been suspected, because of their secretory phenotype (SASP or senescence associated secretory profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives). AISA monoterpens have been characterized as possessing anti-inflammatory capacities in young cells submitted to pro-inflammatory cytokine stimulation. They have also been demonstrated t...
Source: Mechanisms of Ageing and Development - January 3, 2020 Category: Geriatrics Source Type: research

Centenarians: An excellent example of resilience for successful ageing
Publication date: Available online 31 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): C. Borras, M. Ingles, C. Mas-Bargues, M. Dromant, J. Sanz-Ros, A. Román-Domínguez, L. Mallench-Gimeno, J. Gambini, J. ViñaAbstractCentenarians are remarkable not only because of their prolonged life, but also because they compress morbidity until the very last moments of their lives, thus being proposed as a model of successful, extraordinary ageing. From the medical viewpoint, centenarians do not escape the physiological decline or the age-related diseases or syndromes (i.e. frailty), but the rate...
Source: Mechanisms of Ageing and Development - January 1, 2020 Category: Geriatrics Source Type: research

Editorial Board
Publication date: January 2020Source: Mechanisms of Ageing and Development, Volume 185Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - December 28, 2019 Category: Geriatrics Source Type: research

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update
Publication date: Available online 17 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Chiara Villa, Huriye Suphesiz, Romina Combi, Enes AkyuzAbstractWith more than 80 subunits, potassium (K+) channels represent a group of ion channels showing high degree of diversity and ubiquity. They play important role in the control of membrane depolarization and cell excitability in several tissues, including the brain. Controlling the intracellular and extracellular K+ flow in cells, they also modulate the hormone and neurotransmitter release, apoptosis and cell proliferation. It is therefore not surprising that a...
Source: Mechanisms of Ageing and Development - December 18, 2019 Category: Geriatrics Source Type: research

Frailty index and phenotype frailty score: sex- and age-related differences in 5XFAD transgenic mouse model of Alzheimer’s disease
Publication date: Available online 16 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Smilja Todorovic, Natasa Loncarevic-Vasiljkovic, Milena Jovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovic DjordjevicAbstractAlzheimer’s disease patients (AD), as well as AD transgenic mice, are characterized by increased frailty. Furthermore, the assessment of frailty status represents a feasible approach for detecting individuals prone to develop more severe form of AD and for measuring the outcome of existing and putative AD therapeutics. The 5xFAD mouse is one of the widely used transgenic animal m...
Source: Mechanisms of Ageing and Development - December 18, 2019 Category: Geriatrics Source Type: research

Semi-automated quantitation of mitophagy in cells and tissues
Publication date: Available online 13 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Lambert Montava-Garriga, François Singh, Graeme Ball, Ian G. GanleyAbstractMitophagy is a natural phenomenon and entails the lysosomal degradation of mitochondria by the autophagy pathway. In recent years, the development of fluorescent pH-sensitive mitochondrial reporters has greatly facilitated the monitoring of mitophagy by distinguishing between cytosolic mitochondria or those delivered to acidic lysosomes. We recently published the mito-QC reporter, which consists of a mitochondrial outer membrane-localised...
Source: Mechanisms of Ageing and Development - December 15, 2019 Category: Geriatrics Source Type: research

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
Publication date: Available online 5 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yahyah Aman, Johannes Frank, Sofie Hindkjær Lautrup, Adrian Matysek, Zhangming Niu, Guang Yang, Liu Shi, Linda H. Bergersen, Jon Storm-Mathisen, Lene J. Rasmussen, Vilhelm A. Bohr, Hilde Nilsen, Evandro F. FangAbstractNicotinamide adenine dinucleotide (NAD+) is an important natural molecule involved in fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a co-factor for proteins promoting healthy longevity. NAD+ depletion is associated with the hallmarks of ageing and may con...
Source: Mechanisms of Ageing and Development - December 6, 2019 Category: Geriatrics Source Type: research

Revisiting the effects of menopause on the skin: functional changes, clinical studies, in vitro models and therapeutic alternatives
Publication date: Available online 4 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Thamile Luciane Reus, Carla Abdo Brohem, Desiree Cigaran Schuck, Marcio LorenciniAbstractMenopause is a stage in a woman’s life characterized by twelve months of amenorrhoea. This transition happens due to changes in ovarian follicular activity, leading to endocrine, biological and clinical modifications. The main hormones related to these changes and symptoms are oestradiol, LH, FSH, AMH, Inhibin B and GnRH. It is important to point out that the skin is very affected by all these hormone changes, leading to a dec...
Source: Mechanisms of Ageing and Development - December 6, 2019 Category: Geriatrics Source Type: research

Multi-omics approaches to human biological age estimation
Publication date: Available online 28 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Ilya Solovev, Mikhail Shaposhnikov, Alexey MoskalevAbstractMulti-omics approach nowadays increasingly applied to molecular research in many fields of life sciences. Biogerontology is not an exception; multi-omics gives possibility to evaluate complex biomarkers (or panels) which consist of quantitative as well as phenotypic ones. It is especially important because of weak understanding of the nature of aging. The difficulty now is distinguishing between causes and effects of aging. The application of the whole set of m...
Source: Mechanisms of Ageing and Development - November 29, 2019 Category: Geriatrics Source Type: research

Catalytic Antibody (Catabody) Platform for Age-Associated Amyloid Disease: From Heisenberg’s Uncertainty Principle to the Verge of Medical Interventions
Publication date: Available online 26 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Stephanie A. Planque, Richard J. Massey, Sudhir PaulAbstractQuantum mechanics-based design of useful catalytic antibodies (catabodies) failed because of the uncertain structure of the dynamic catalyst-substrate complex. The Catabody Platform emerged from discovery of beneficial germline gene catabodies that hydrolyzed self-proteins by transient covalent pairing of the strong catabody nucleophile with a weak target protein electrophile. Catabodies have evolved by Darwinian natural selection for protection against misfol...
Source: Mechanisms of Ageing and Development - November 26, 2019 Category: Geriatrics Source Type: research

Increased Oxidative Stress, Inflammation, and Glutamate: Potential Preventive and Therapeutic Targets for Hearing Disorders
Publication date: Available online 22 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Kadar N. Prasad, Stephen C. BondyAbstractHearing disorders constitute one of the major health concerns in the USA. Decades of basic and clinical studies have identified numerous ototoxic agents and investigated their modes of action on the inner ear, utilizing tissue culture as well as animal and human models. Current preventive and therapeutic approaches are considered unsatisfactory. Therefore, additional modalities should be developed. Many studies suggest that increased levels of oxidative stress, chronic inflammat...
Source: Mechanisms of Ageing and Development - November 23, 2019 Category: Geriatrics Source Type: research

Telomere length analysis on leukocytes derived from patients with Huntington Disease
This study contributes with current evidence suggesting a potential role of telomere shortening as HD biomarker. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - November 23, 2019 Category: Geriatrics Source Type: research

Endurance training improves plasma superoxide dismutase activity in healthy elderly
Publication date: Available online 22 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Roberta Ceci, Guglielmo Duranti, Ester Sara Di Filippo, Danilo Bondi, Vittore Verratti, Christian Doria, Daniela Caporossi, Stefania Sabatini, Ivan Dimauro, Tiziana PietrangeloAbstractWe aimed to characterize the plasma redox homeostasis as underlying physiological mechanisms of specific training on healthy elderly. 51 healthy volunteers were trained to endurance, resistance, Neuro-Muscular Electrical Stimulation for 12 weeks, 3 sessions/w, all applied to lower limbs. We assessed ex-post quadriceps’ maximal volun...
Source: Mechanisms of Ageing and Development - November 23, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: December 2019Source: Mechanisms of Ageing and Development, Volume 184Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - November 16, 2019 Category: Geriatrics Source Type: research

Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways
Publication date: Available online 9 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Saara Marttila, Kasit Chatsirisupachai, Daniel Palmer, João Pedro de MagalhãesAbstractAgeing-associated changes in the protein coding transcriptome have been extensively characterised, but less attention has been paid to the non-coding portion of the human genome, especially to long non-coding RNAs (lncRNAs). Only a minority of known lncRNAs have been functionally characterised; however, a handful of these lncRNAs have already been linked to ageing-associated processes. To gain more information on the effe...
Source: Mechanisms of Ageing and Development - November 10, 2019 Category: Geriatrics Source Type: research

Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients
Publication date: Available online 2 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Moisés Garcés, M. Isabel Guijarro, Antonia Vargas, Juan J. Badiola, Marta MonzónAbstractNeurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are considered prion-like disorders because they are all proteinopathies in which aberrant proteins spread throughout the brain during disease progression. The overall aim of this study is to determine how glial cells are commonly involved in the neurodegeneration progress observed in all these pathologies. The suggestion that they are c...
Source: Mechanisms of Ageing and Development - November 4, 2019 Category: Geriatrics Source Type: research

Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease
Publication date: Available online 1 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Tao-Ran Li, Xiao-Ni Wang, Can Sheng, Yu-Xia Li, Frederic Zhen-Tao Li, Yu Sun, Ying HanAbstractAlzheimer’s disease (AD) is characterized by a series of interacting pathophysiological cascades, including the aggregation of β-amyloid plaques and the formation of neurofibrillary tangles derived from hyperphosphorylated tau proteins. AD is the cause of approximately 70% of dementia, an irreversible and untreatable syndrome at its late stage. Hence, more efforts should be devoted to identifying at-risk or preclinic...
Source: Mechanisms of Ageing and Development - November 2, 2019 Category: Geriatrics Source Type: research

Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells
In this study, we explored the role of Dsg3 on dome formation, reactive oxygen species (ROS) production and transepithelial electrical resistance (TER) in MDCK cells, a kidney epithelial cell model widely used to study cell differentiation and tight junction formation and integrity. We show that overexpression of Dsg3 constrained nuclear ROS production and cellular doming in confluent cell cultures and these features coincided with augmented TER and enhanced tight junction integrity. Conversely, cells expressing dominant-negative Dsg3ΔC mutants exhibited heightened ROS production and accelerated doming, accompanied b...
Source: Mechanisms of Ageing and Development - November 1, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2019Source: Mechanisms of Ageing and Development, Volume 183Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - October 26, 2019 Category: Geriatrics Source Type: research

Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice
Publication date: Available online 21 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Francesco Piccirillo, Myriam Carpenito, Giuseppe Verolino, Camilla Chello, Annunziata Nusca, Mario Lusini, Cristiano Spadaccio, Francesco Nappi, Germano Di Sciascio, Antonio NennaAbstractAging results in functional and structural changes in the cardiovascular system, translating into a progressive increase of mechanical vessel stiffness, due to a combination of changes in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell migration and proliferation. The two pivotal mechanisms of aging-...
Source: Mechanisms of Ageing and Development - October 23, 2019 Category: Geriatrics Source Type: research

NF-κB signaling in skin aging
Publication date: Available online 18 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yujia Wang, Lian Wang, Xiang Wen, Dan Hao, Nan Zhang, Gu He, Xian JiangAbstractSkin is the largest organ of the body, and is prone to be affected by external environmental factors. Skin aging is caused by both genetic and environmental factors. Furthermore, aging skin tissue is known to create a permissive tissue microenvironment that promotes the initiation, progression and resistance of cancer cells by promoting the senescence-associated secretory phenotype (SASP). Therefore, more attention should be paid to skin agin...
Source: Mechanisms of Ageing and Development - October 20, 2019 Category: Geriatrics Source Type: research

Glycoanalysis of the placental membrane glycoproteins throughout placental development
Publication date: Available online 4 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Dragana Robajac, Romana Masnikosa, Marek Nemčovič, Martina Križáková, Ľudmila Belická Kluková, Peter Baráth, Jaroslav Katrlík, Olgica NedićAbstractStructural changes of glycans are observed in different (patho)physiological conditions. Human placental membrane (glyco)proteins were isolated from the first and third trimester placentas of mothers at different ages. By using lectin microarray, we demonstrated that the placental membrane N-glycome contains several N-glycan group...
Source: Mechanisms of Ageing and Development - October 5, 2019 Category: Geriatrics Source Type: research

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories
Publication date: Available online 28 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Jaana Van Gastel, Huan Cai, Wei-Na Cong, Wayne Chadwick, Caitlin Daimon, Hanne Leysen, Jhana O. Hendrickx, Robin De Schepper, Laura Vangenechten, Jens Van Turnhout, Jasper Verswyvel, Kevin G. Becker, Yongqing Zhang, Elin Lehrmann, William H. Wood, Bronwen Martin, Stuart MaudsleyAbstractIn most species, females live longer than males. An understanding of this female longevity advantage will likely uncover novel anti-aging therapeutic targets. Here we investigated the transcriptomic responses in the hypothalamus –...
Source: Mechanisms of Ageing and Development - September 29, 2019 Category: Geriatrics Source Type: research

Replicative senescence is distinguishable from DNA damage-induced senescence by increased methylation of promoter of rDNA and reduced expression of rRNA
Publication date: Available online 27 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Reiko Sanokawa-Akakura, Shin Akakura, Elena A. Ostrakhovitch, Siamak TabibzadehAbstractHuman fibroblasts become senescent after a limited number of replications or by diverse stresses, such as DNA damage. However, replicative and damage induced senescence are indistinguishable in respect to proliferation cessation and expression of senescence markers, senescence-associated β-galactosidase, p16 and p21. Here, we show that senescence types can be distinguished by reduced levels of 18S, 5.8S and 28S rRNA, in replica...
Source: Mechanisms of Ageing and Development - September 28, 2019 Category: Geriatrics Source Type: research

Interferons: a molecular switch between damage and repair in ageing and Alzheimer’s disease
Publication date: Available online 18 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): N. Gorlé, R.E. VandenbrouckeAbstractAlzheimer’s disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer’s disease. Th...
Source: Mechanisms of Ageing and Development - September 20, 2019 Category: Geriatrics Source Type: research

Telomere length and physical performance among older people—The Helsinki Birth Cohort Study
Publication date: October 2019Source: Mechanisms of Ageing and Development, Volume 183Author(s): Max J. Åström, Mikaela B. von Bonsdorff, Mia-Maria Perälä, Minna K. Salonen, Taina Rantanen, Eero Kajantie, Mika Simonen, Pertti Pohjolainen, Markus J. Haapanen, Maria A. Guzzardi, Patricia Iozzo, Hannu Kautiainen, Johan G. ErikssonAbstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and...
Source: Mechanisms of Ageing and Development - September 16, 2019 Category: Geriatrics Source Type: research

Classical Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide Stimulation
In conclusion, aged classical monocytes maintain effector and metabolic functions during glucose deprivation, at least in an ex vivo context. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

Ischemic Stroke In Neonatal And Adult Astrocytes
The objective of this paper is to review current information regarding astrocytes function after a stroke in neonatal and adult brain. Based on the current literature, there are some molecular differences related to blood brain barrier (BBB) homeostasis disruption, inflammation and reactive oxygen species (ROS) mediated injury between the immature and mature brain after an ischemic event. In particular, astrocytes, the main glial cells in brain, play a different role in neonatal and adult brain after stroke, as time course of glial activation is strongly age dependent. Moreover, the present review provides further insight ...
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

Telomere length and physical performance among older people – the Helsinki Birth Cohort Study
Publication date: Available online 3 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Max J. Åström, Mikaela B. von Bonsdorff, Mia-Maria Perälä, Minna K. Salonen, Taina Rantanen, Eero Kajantie, Mika Simonen, Pertti Pohjolainen, Markus J. Haapanen, Maria A. Guzzardi, Patricia Iozzo, Hannu Kautiainen, Johan G. ErikssonAbstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 ...
Source: Mechanisms of Ageing and Development - September 4, 2019 Category: Geriatrics Source Type: research

Regulation of cellular senescence by retinoid X receptors and their partners
Publication date: Available online 30 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Nadine Martin, Xingjie Ma, David BernardABSTRACTCellular senescence is a response characterized by a stable cell proliferation arrest and a senescence-associated secretory phenotype (SASP) which can be induced by many stresses, including telomere shortening and oncogene activation. Senescence is crucially involved in a variety of physiopathological contexts, such as cancer and aging. Given the fundamental role of this process, senescence needs to be tightly regulated. In the last decade, the key implication of nuclear re...
Source: Mechanisms of Ageing and Development - August 31, 2019 Category: Geriatrics Source Type: research

Feed-forward Loop between Body Composition, Strength and Performance in Older Adults
We present evidence of a feed-forward loop relationship between certain components of the frailty syndrome: body composition, strength and physical performance level.The evidence has been found by performing statistical analysis on measures from 878 females and 588 males aged 60-97, participating in the Rancho Bernardo Study, followed for at least three visits over 12 years. In the analysis, we have used fat mass and lean mass (measured by whole body DXA scans), grip strength (measured by dynamometer) and time to get up and walk a certain distance. The results provide evidence of a feed-forward loop between these variables...
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research