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All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause
Publication date: January 2015 Source:The Journal of Steroid Biochemistry and Molecular Biology, Volume 145 Author(s): Fernand Labrie Following the arrest of estradiol secretion by the ovaries at menopause, all estrogens and all androgens in postmenopausal women are made locally in peripheral target tissues according to the physiological mechanisms of intracrinology. The locally made sex steroids exert their action and are inactivated intracellularly without biologically significant release of the active sex steroids in the circulation. The level of expression of the steroid-forming and steroid-inactivating enzymes is sp...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 11, 2014 Category: Biochemistry Source Type: research
Strategies to improve the outcomes of assisted reproduction in women with polycystic ovarian syndrome: a systematic review and meta‐analysis
ConclusionThere is low to moderate quality evidence suggesting that antagonist protocols are preferable to agonist ones, because they reduce the incidence of OHSS without interfering with clinical pregnancy and live birth for women with PCOS. Additionally there is low quality evidence pointing a benefit for metformin supplementation on clinical pregnancy and live birth; and that the ovulation induction and estradiol seems to be equally effective for endometrial preparation before frozen embryo transfer for women with PCOS. For all other interventions, the quality of the evidence is of very low quality, not allowing any meaningful conclusions.
Source: Ultrasound in Obstetrics and Gynecology - February 29, 2016 Category: Radiology Authors: M. Kollmann, W.P. Martins, M.L.S. Lima, L. Craciunas, C.O. Nastri, A. Richardson, N. Raine‐Fenning Tags: Systematic Review Source Type: research
Strategies to improve the outcomes of assisted reproduction in women with polycystic ovarian syndrome: a systematic review and meta-analysis.
CONCLUSION: There is low to moderate quality evidence suggesting that antagonist protocols are preferable to agonist ones, because they reduce the incidence of OHSS without interfering with clinical pregnancy and live birth for women with PCOS. Additionally there is low quality evidence pointing a benefit for metformin supplementation on clinical pregnancy and live birth; and that the ovulation induction and estradiol seems to be equally effective for endometrial preparation before frozen embryo transfer for women with PCOS. For all other interventions, the quality of the evidence is of very low quality, not allowing any m...
Source: The Ultrasound Review of Obstetrics and Gynecology - February 29, 2016 Category: Radiology Authors: Kollmann M, Martins WP, Lima ML, Craciunas L, Nastri CO, Richardson A, Raine-Fenning N Tags: Ultrasound Obstet Gynecol Source Type: research
Estrogen-based hormone therapy in women with primary ovarian insufficiency: a systematic review
ConclusionsEvidence supporting bone and cardiovascular benefits of HT in women with POI is limited by high risk of bias, reliance on surrogate outcomes, and heterogeneity of trials regarding the formulation, dose, route of administration, and regimen of HT. Further research addressing patient important outcomes such as fractures, stroke, and cardiovascular mortality are crucial to optimize benefits of this therapy.
Source: Endocrine - October 16, 2017 Category: Endocrinology Source Type: research
Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women
In conclusion, our findings suggest CRT is a critical intervention element that can significantly modulate circulating levels of adipokines. Interestingly, these effects were intensified when Zataria Multiflora supplementation added to CRT regimen, whereas ZM alone had little effects on measured adipokines. This implies that the beneficial effects of CRT on circulating levels of adipokines could be amplified with simultaneous intake of ZM; that is, they act synergistically. Consequently, CRT alone or its combination with ZM could be considered by researchers and health practitioners as a non-pharmacologic means to modulate...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research
Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset fathers, Callithrix jacchus
Horm Behav. 2022 Mar 30;142:105162. doi: 10.1016/j.yhbeh.2022.105162. Online ahead of print.ABSTRACTCommon marmoset fathers are highly involved in care of their infants. However, variability exists in their response to infant behavior even in paternally experienced fathers. Using infant distress cries as a motivation test, we investigated: 1. the differences in paternally experienced fathers' motivation to search for the infant vocalization stimuli; 2. the relationship between a father's motivation to search for the source of the infant cries and testosterone levels; and 3. if there is a rapid steroidogenesis pathway leadi...
Source: Hormones and Behavior - April 2, 2022 Category: Endocrinology Authors: Natalie J Dukes Hayley Ash Gabriela de Faria Oliveira Megan E Sosa Robinson W Goy Ricki J Colman Toni E Ziegler Source Type: research
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use
CONCLUSIONS: Findings from this review should be interpreted with caution due to low- and very low-certainty evidence. Included trials were limited; the majority of the evidence was derived from single trials with few participants. Further research requires larger trials and improved trial reporting. The use of vitamin B1 and mefenamic acid to treat heavy menstruation and tolfenamic acid to prevent heavy menstruation associated with Cu IUD should be investigated. More trials are needed to generate evidence for the treatment and prevention of heavy and painful menstruation associated with LNG IUD.PMID:36017945 | DOI:10.1002...
Source: Cochrane Database of Systematic Reviews - August 26, 2022 Category: General Medicine Authors: Karen Christelle Mohd N Norhayati Sharifah Halimah Jaafar Source Type: research
Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review
CONCLUSION: In conclusion, vitamin E isoforms, isolated or associated, showed antitumor and chemopreventive activity. However, due to studies heterogeneity, there is a need for further analysis to establish dose, form, supplementation time and breast cancer stage.PMID:36657931 | DOI:10.1016/j.clnesp.2022.11.001
Source: Clinical Breast Cancer - January 19, 2023 Category: Cancer & Oncology Authors: Maria do Perpetuo Socorro de Sousa Coelho Irislene Costa Pereira Kynnara Gabriella Feitosa de Oliveira Iara Katryne Fonseca Oliveira M árcia Dos Santos Rizzo Victor Alves de Oliveira Felipe Cavalcanti Carneiro da Silva Francisco Leonardo Torres-Leal Jo Source Type: research
Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women
Conclusions: Although treatment with celecoxib before or after the LH surge increases the rate of ovulatory dysfunction, most women ovulate normally. Thus, this selective COX2 inhibitor appears to be of limited usefulness as a potential emergency contraceptive.
Source: Contraception - August 20, 2012 Category: OBGYN Authors: Alison B. Edelman, Jeffrey T. Jensen, Carmen Doom, Jon D. Hennebold Tags: Original Research Articles Source Type: research
EAA clinical practice guidelines —gynecomastia evaluation and management
ConclusionsThe purpose of GM assessment should be the detection of underlying pathological conditions, reversible causes (administration/abuse of aggravating substances), and the discrimination from other breast lumps, particularly breast cancer. Assessment should comprise a thorough medical history and physical examination of the breast and genitalia (including testicular ultrasound). A set of laboratory investigations may integrate the evaluation: testosterone (T), estradiol (E2), sex hormone ‐binding globulin (SHBG), luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH), pro...
Source: Andrology - May 15, 2019 Category: Urology & Nephrology Authors: G. A. Kanakis,
L. Nordkap,
A. K. Bang,
A. E. Calogero,
G. B ártfai,
G. Corona,
G. Forti,
J. Toppari,
D. G. Goulis,
N. Jørgensen Tags: Original Article Source Type: research
Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose –Response Analysis
Conclusions:
Developmental BPA exposures heighten prostate cancer susceptibility in a complex dose- and lobe-specific manner. Importantly, elevated carcinogenic risk is found at doses that yield undetectable serum free BPA. Dose-specific epigenetic modifications of selected genes provide a mechanistic framework that may connect early-life BPA to later-life predisposition to prostate carcinogenesis. https://doi.org/10.1289/EHP1050
Received: 1 September 2016
Revised: 13 January 2017
Accepted: 19 January 2017
Published: 11 July 2017
Address correspondence to G.S. Prins, Dept. of Urology, University of Illinois at Chicago...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis
Conclusions:
Our results provide suggestive evidence of the potential for environmental exposure to phthalates and/or BPA to disrupt circulating vitamin D levels in pregnancy. https://doi.org/10.1289/EHP1178
Received: 03 October 2016
Revised: 10 May 2017
Accepted: 12 May 2017
Published: 31 August 2017
Address correspondence to J.D. Meeker, Dept. of Environmental Health Sciences, University of Michigan School of Public Health, 1835 SPH I, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029 USA. Telephone: (734) 764-7184. Email: meekerj@umich.edu
Supplemental Material is available online (https://doi.org/10.1289/EH...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan
Conclusion
Autoimmune disease states show strong associations with endocrinological changes in human and animal studies. There is clear evidence for the role of sex steroids in the immune disturbances that result in autoimmune diseases (Figure 2). The majority of women who pass through the different endocrinological transition states do not succumb to autoimmune diseases.
FIGURE 2
Figure 2. Factors that contribute to increased incidence and prevalence of autoimmunity in women. In women (46XX) with genetic susceptibility to autoimmune states, external environmental stimuli affect modifying factors as well as endo...
Source: Frontiers in Endocrinology - April 28, 2019 Category: Endocrinology Source Type: research
Differences in the sex hormone levels in the menstrual cycle due to tobacco smoking - a myth or reality?
CONCLUSIONS: Active and passive smoking may be an important contributor to reproductive health issues and deserves a greater focus in health education programs directed towards women of reproductive age.PMID:34855194 | DOI:10.5603/EP.a2021.0097
Source: Endokrynologia Polska - December 2, 2021 Category: Endocrinology Authors: Ewa Florek Wojciech Piekoszewski Agata Czarnywojtek Anna S ędziak Wojciech Jawie ń Anna Dera-Szymanowska Marta Szukalska Krzysztof Szymanowski Marek Chuchracki Marek Rucha ła Source Type: research
