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Total 409 results found since Jan 2013.

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Six patients with rare blood disease are doing well after gene therapy clinical trial
UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,” said Dr. Donald K...
Source: UCLA Newsroom: Health Sciences - January 28, 2020 Category: Universities & Medical Training Source Type: news

Hydroxychloroquine Fails to Help Coronavirus Patients in Largest Study of the Drug to Date
In a study published in the New England Journal of Medicine, scientists led by a team at Columbia University found that people infected with COVID-19 taking hydroxychloroquine do not fare better than those not receiving the drug. The study published Thursday is the largest to date to investigate the drug, which is approved by the U.S. Food and Drug Administration to treat malaria and certain autoimmune disorders, as a treatment for COVID-19. Dr. Neil Schluger, chief of the division of pulmonary, allergy and critical care medicine at Columbia, and his team studied more than 1,300 patients admitted to New York-Presbyterian H...
Source: TIME: Health - May 7, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

The Last Three Decades of Contact Dermatitis: A Bibliometric Analysis of Global Publications on Contact Dermatitis
Conclusion Physicians from developing and least developed countries should be supported to perform novel bibliometric researches on contact dermatitis.
Source: JDNA: Journal of the Dermatology Nurses Association - September 1, 2020 Category: Dermatology Tags: FEATURE ARTICLES Source Type: research

IJERPH, Vol. 17, Pages 8917: Five Predictors Affecting the Prognosis of Patients with Severe Odontogenic Infections
Conclusions: Besides clinical symptoms of severity, complications of severe odontogenic infection are predicted by measurables and objectives criteria as penicillin allergy, mandibular molar, C-reactive protein level, psychiatric disorders and alcohol abuse. Their specific association potentialize the risks. IRB number: CE-CIC-GREN-12-08.
Source: International Journal of Environmental Research and Public Health - November 30, 2020 Category: Environmental Health Authors: Pham Dang Delbet-Dupas Mulliez Devoize Dallel Barth élémy Tags: Article Source Type: research

We Used to Have a Lyme Disease Vaccine. Are We Ready to Bring One Back?
At my animal hospital in upstate New York, an epicenter of the U.S. tick epidemic, my dog Fawn lets out a whimper as the veterinarian injects her with her annual Lyme disease shot. I roll my eyes. She doesn’t know how good she has it. The injection means that if a tick bites her (and in rural New York, a tick always does), the creepy crawly will feast on dog blood that’s been supercharged with a Lyme bacteria-killing substance, and Lyme disease won’t be transmitted to Fawn. I wish I could be shot up with that superpower. Currently, there is no human vaccine for Lyme disease—even though more than two...
Source: TIME: Health - June 17, 2021 Category: Consumer Health News Authors: Mandy Oaklander Tags: Uncategorized Disease feature Source Type: news

First-Dose Coronavirus 2019 Vaccination Coverage among the Residents of Long-Term Care Facilities in France
Conclusions: About 3 out of 10 residents remained unvaccinated, and half of the LTCFs had a coverage rate #x3c;70%. This suggests that COVID-19 will remain a threat to many LTCFs after the vaccination campaigns.Gerontology
Source: Gerontology - August 11, 2021 Category: Geriatrics Source Type: research

New Keratoconus Risk Factors: A Cross-Sectional Case-Control Study
CONCLUSION: This study confirmed the association between keratoconus and eye rubbing, family history, and allergy. It highlighted the role of pressure on the eyes during sleep. Other less known risk factors such as dry eyes and smoking exposure should be explored in future studies.PMID:36211596 | PMC:PMC9534614 | DOI:10.1155/2022/6605771
Source: Journal of Ophthalmology - October 10, 2022 Category: Opthalmology Authors: Eloi Debourdeau Gabriel Planells Chloe Chamard David Touboul Max Villain Pascal Demoly Fanny Babeau Pierre Fournie Vincent Daien Source Type: research

Changes in the European baseline series from 1981 to 2011 in a French dermatology-allergology centre.
CONCLUSION: Due to modifications in exposure to allergens, the incidence of contact sensitization can change, but nickel sulphate sensitization is increasing despite recent European directives. Allergens with less than 1% of positive results could be withdrawn from the EBS, with benzalkonium chloride, methylisothiazolinone and lavender absolute being added. PMID: 24034634 [PubMed - in process]
Source: Annales de Dermatologie et de Cenereologie - August 1, 2013 Category: Dermatology Authors: Schoeffler A, Waton J, Latarche C, Poreaux C, Cuny JF, Schmutz JL, Barbaud A Tags: Ann Dermatol Venereol Source Type: research

Relevance of EORTC Criteria for the Diagnosis of Invasive Aspergillosis in HIV-Infected Patients, and Survival Trends Over a 20-Year Period in France
Conclusions. In the cART era, EORTC criteria, developed for use in hematology/oncology, still applied to only half the cases diagnosed among HIV-infected patients. A rapid diagnosis of IA is paramount to improve survival. For patients who do not fulfill the EORTC definition, we suggest that the addition of "HIV infected with a CD4 count <100 cells/µL" to the EORTC host criteria be validated.
Source: Clinical Infectious Diseases - September 25, 2015 Category: Infectious Diseases Authors: Denis, B., Guiguet, M., de Castro, N., Mechai, F., Revest, M., Melica, G., Costagliola, D., Lortholary, O., for the French Hospital Database on HIV Agence Nationale de Recherche sur le SIDA et les hepatites virales, France CO4 Tags: ARTICLES AND COMMENTARIES Source Type: research

Survey on practice of venom immunotherapy in France.
CONCLUSIONS: Our study shows that most recommendations were fully or partially followed and may need reminding, but many points need to be completed or updated with new tools and knowledge acquired during the last 10 years. PMID: 26925131 [PubMed - as supplied by publisher]
Source: Archives of Medical Science - March 1, 2016 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Infant food diversification. Assessment of practices in relation to French recommendations in pediatricians and pediatric residents in southern France.
CONCLUSION: Pediatricians and pediatric residents partially applied the current recommendations on the introduction of solid food. PMID: 27642151 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - September 14, 2016 Category: Pediatrics Authors: Banti T, Carsin A, Chabrol B, Reynaud R, Fabre A Tags: Arch Pediatr Source Type: research

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research