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Total 258 results found since Jan 2013.

Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole.
CONCLUSIONS: This study shows that fexofenadine (FXF - antihistamine drug) and osthole exhibit selective COX-2 enzyme inhibitory activity. The selective COX-2 activity of osthole may explain further the anti-inflammatory properties of osthole in relieving congestion in allergic rhinitis, and as distinctive effects between FXF and osthole were observed, individual antihistamines may have different modes of action via the COX enzyme system. PMID: 30953868 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - April 2, 2019 Category: Allergy & Immunology Authors: Kordulewska NK, Kostyra E, Chwała B, Moszyńska M, Cieślińska A, Fiedorowicz E, Jarmołowska B Tags: Int Immunopharmacol Source Type: research

A guinea pig model of Ciwujia Injection-induced anaphylaxis for allergic substance screening
ConclusionThis guinea pig model may provide a powerful tool to study the mechanism in CWJI induced anaphylaxis and screen the allergic source of CWJI.
Source: Chinese Herbal Medicines - March 10, 2019 Category: Complementary Medicine Source Type: research

Ask Well: Can You Get Over a Food Intolerance?
Foods most often associated with intolerances were chocolate, food additives, citrus fruits, fish, shellfish, milk, cheese, eggs and nuts.
Source: NYT Health - February 15, 2019 Category: Consumer Health News Authors: RICHARD KLASCO, M.D. Tags: Chinese Food (Cuisine) Allergies Asthma Headaches Milk Monosodium Glutamate Food Additives Source Type: news

Association between food allergy and ankylosing spondylitis: An observational study
Food allergies can alter the gut microbiome composition, increasing the risk of conditions such as ankylosing spondylitis (AS). To identify the association between specific allergens and AS, we investigated the differences in the serum levels of 14 food antigen-specific immunoglobulin (Ig) G between AS patients and healthy participants. The association between the levels of these antibodies and disease activity was assessed by measuring the inflammatory marker C-reactive protein (CRP). We enrolled 75 AS patients and 78 healthy controls who had undergone antigen-specific IgG tests in West China Hospital between January 20...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Next-Generation Approaches for the Treatment of Food Allergy
AbstractPurpose of ReviewIgE-mediated food allergies are an increasing health concern, and current management includes food avoidance and use of emergency medications. Effective treatment of food allergy is highly desirable. Next generation approaches for the treatment of food allergy aim to improve both safety and efficacy, potentially including long-term tolerance.Recent FindingsOral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) will likely be integrated into clinical practice as part of food allergy management in the near future. Newer approaches, such as sublingual immunotherapy (SLIT), modified proteins, l...
Source: Current Allergy and Asthma Reports - January 28, 2019 Category: Allergy & Immunology Source Type: research

Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015.
CONCLUSIONS: Our findings suggest that clinicians should pay attention to psychiatric ADRs and be alert for SARs, especially when three or more AEDs are used together. Moreover, active surveillance might provide another method of pharmacovigilance in China. PMID: 30642405 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - January 17, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Canis familiaris allergen Can f 7: Expression, purification and analysis of B cell epitopes in Chinese children with dog allergies.
Abstract Dogs are a major source of indoor allergens. However, the prevalence of dog allergies in China remains unclear, especially in children. In the present study, Can f 7, a canine allergen belonging to the Niemann pick type C2 protein family, was selected to study its sensitization rate in Chinese children with dog allergies. The Can f 7 gene was subcloned into a pET‑28a vector and expressed in Escherichia coli BL21 (DE3) cells. Recombinant Can f 7 was purified by nickel affinity chromatography, identified by SDS‑PAGE electrophoresis, and had its allergenicity assessed by western blot, ELISA and basophil ...
Source: International Journal of Molecular Medicine - January 15, 2019 Category: Molecular Biology Authors: Wang RQ, Wang YJ, Xu ZQ, Zhou YJ, Cao MD, Zhu W, Sun JL, Wei JF Tags: Int J Mol Med Source Type: research

Modern life makes children allergic. A cross-sectional study: associations of home environment and lifestyles with asthma and allergy among children in Tianjin region, China
ConclusionsThe results indicate that a “modern” home environment together with a modern lifestyle is associated with increased prevalences of asthma and allergies among children. Appropriate indoor environmental interventions and education of children’s caregivers are important in the management of childhood asthma and allergy.
Source: International Archives of Occupational and Environmental Health - January 9, 2019 Category: Occupational Health Source Type: research

Regional Differences in Food Allergies
This study demonstrates an unmet need in China for a thorough investigation of the prevalence of food allergies in China, the specific foods involved, and characterization of the specific antigenic triggers of food allergy with respect to ethnicity, age, and diet in China.
Source: Clinical Reviews in Allergy and Immunology - January 5, 2019 Category: Allergy & Immunology Source Type: research

Molecules, Vol. 24, Pages 102: Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.
d Perilla frutescens (L.) Britt. (PF) is an annual herbal medicinal, aromatic, functional food, and ornamental plant that belongs to the mint family, Lamiaceae. The origin of perilla traces back to East Asian countries (China, Japan, Korea, Taiwan, Vietnam, and India), where it has been used as a valuable source of culinary and traditional medicinal uses. The leaves, seeds, and stems of P. frutescens are used for various therapeutic applications in folk medicine. In the absence of a comprehensive review regarding all aspects of perilla, this review aims to present an overview pertaining to the botanical drug, ethnobota...
Source: Molecules - December 28, 2018 Category: Chemistry Authors: Hiwa M. Ahmed Tags: Review Source Type: research

Molecules, Vol. 23, Pages 3114: Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study
This study demonstrated that tanshinone I is a Syk inhibitor with mast cell degranulation inhibitory activity. Tanshinone I may be a potential lead compound for developing effective and safe Syk-inhibiting drugs.
Source: Molecules - November 28, 2018 Category: Chemistry Authors: Xing Wang Junfang Guo Zhongqi Ning Xia Wu Tags: Article Source Type: research

Suppression of TGP on myocardial remodeling by regulating the NF-κB pathway
This study aims to investigate the effects of TGP on myocardial remodeling by regulating the nuclear factor kappa B cells (NF-κB) pathway. SD rats were selected and divided into five groups (n = 8), control, sham-operated, Captopril, low dose TGP and high dose TGP respectively. The pressure-overload method was adopted by abdominal aorta ligation to induce the CHF. Furthermore, collagen fibers detected by picrosirius red staining and expression of NF-kB, TGF-β1 by immunohistochemistry and observed under a polarized microscope and assessed by image-pro plus 6.0. Matrix metalloproteinase’s (MMP)-2, -9 mRNA levels by r...
Source: Biomedicine and Pharmacotherapy - October 10, 2018 Category: Drugs & Pharmacology Source Type: research