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Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs
This study was supported by NIH/NIAID grants R01AI102766 (YL), P01AI104722 (RW and YL), UM1 AI100663 (RW), and Bill and Melinda Gates Foundation grant OPP1084519 (RW). JS is a trainee of NIH training grant T32AI125186A to Anne Simon at University of Maryland, College Park. This study was also partially funded by the International AIDS Vaccine Initiative (IAVI) (RW) with the generous support of United States Agency for International Development (USAID), and Ministry of Foreign Affairs of the Netherlands. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or ...
Source: Frontiers in Microbiology - April 22, 2019 Category: Microbiology Source Type: research

Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
Discussion Tibroviruses are highly undercharacterized rhabdoviruses with unknown pathogenic potential. All isolated tibroviruses (BAV, BHV, CPV, SWBV, and TIBV) have only been found in biting midge vectors or in various, apparently healthy non-human mammals (Cybinski et al., 1980; Standfast et al., 1984; Cybinski and Gard, 1986; Gibbs et al., 1989). The discovery of BASV, EKV-1, and EKV-2 genomes in human sera (Grard et al., 2012; Stremlau et al., 2015) suggests that at least some tibroviruses could infect humans. Because BASV was discovered in the serum of a severely ill individual, tibroviruses should be considered pote...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research

The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection
Conclusion In conclusion, our data show that R. rickettsii exerts a modulatory effect on the transcriptional profile the SG of A. aureolatum. Moreover, RNAi experiments demonstrated that the knockdown of one microplusin increases the susceptibility of ticks to infection, suggesting that this is one important factor for the control of R. rickettsii. The functional characterization of the additional CDSs modulated by infection is warranted and might reveal other factors that interfere with the acquisition and/or transmission of this tick-borne pathogen. Ethics Statement All procedures involving vertebrate animals were car...
Source: Frontiers in Physiology - May 2, 2019 Category: Physiology Source Type: research

Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population
ConclusionPolymorphisms in the CYSLTR2 gene are associated with asthma, atopy markers and helminth infection in Brazilian individuals, which may lead to protection or risk for such conditions, however, more studies are needed to evaluate the functional of this variants here in described.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - May 7, 2019 Category: Lipidology Source Type: research

Johnson & Johnson ’ s Coronavirus Vaccine Enters Phase 3 Trial With Beth Israel
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 23, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Beth Israel Deacones Medical Center Coronavirus Johnson & Johnson Source Type: news

Biden ’s First Three Steps to Getting COVID-19 Vaccines to Every American
Less than a week after taking office, President Joe Biden announced three major steps to improve the country’s vaccination plans, and his Administration’s COVID-19 response team held its first press briefing. On Jan. 26, the President outlined the first three steps his team will take as part of a National Action Strategy for responding to the pandemic. First, the Administration will increase minimum weekly shipments of vaccines to states to 10 million doses, from the current 8.6 million. Next, Biden guaranteed these shipment numbers for the next three weeks, which allows states to plan out for the next month ho...
Source: TIME: Health - January 27, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Immunoproteomic identification of allergenic proteins in pecan (Carya illinoinensis) pollen
This study has identified 17 IgE binding proteins from pecan pollen including proteins widely recognized as allergens and panallergens. These findings will contribute to develop specific diagnosis and treatment of pecan pollen allergy. SIGNIFICANCE: Pecan is a tree highly valued for its fruits that have a great commercial value. To date three pecan seed storage proteins have been officially recognized by the WHO/IUIS allergen nomenclature subcommittee as food allergens (Car i 1, Car i 2 and Car i 4). Pecan tree pollen is highly allergenic and a clinically relevant cause of allergies in North America (USA and Mexico) and re...
Source: Journal of Proteomics - August 15, 2021 Category: Biochemistry Authors: Martha Beatriz Morales-Amparano Alejandra Valenzuela-Corral Gabriela Ramos-Clamont Montfort Luz V ázquez-Moreno Abraham Escobedo-Moratilla Guillermo Pastor-Palacios Cesar é Ovando-Vázquez Luis M Teran Jos é Ángel Huerta-Ocampo Source Type: research

COVID-19 scenario and recommendations on the continuity of immunobiological therapy in patients with atopic asthma in Brazil and Latin America
Expert Rev Respir Med. 2022 Jan 17. doi: 10.1080/17476348.2022.2027758. Online ahead of print.ABSTRACTINTRODUCTION: With the abrupt establishment of the COVID-19 pandemic, treatment for immunological diseases may be influenced by the SARS-CoV-2 infection, including asthma and other allergies. Immunobiologics play a pivotal role in the management of severe symptoms of allergy and an opinion regarding the continuity of this treatment during the COVID-19 pandemic must be issued.AREAS COVERED: In Brazil and other countries, patients with severe asthma were included in the priority groups for COVID-19 vaccination, even those wh...
Source: Expert Review of Respiratory Medicine - January 17, 2022 Category: Respiratory Medicine Authors: Rafael de Oliveira Resende Vin ícius José de Oliveira Alessandro Sousa Correa Pedro Trica de Ara újo Ernesto Akio Taketomi Source Type: research