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Condition: Benign Prostatic Hyperplasia

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Total 117 results found since Jan 2013.

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

Cancers, Vol. 12, Pages 1122: The Role of lncRNAs TAPIR-1 and -2 as Diagnostic Markers and Potential Therapeutic Targets in Prostate Cancer
Muders Sommer Baretton Wirth Horn In search of new biomarkers suitable for the diagnosis and treatment of prostate cancer, genome-wide transcriptome sequencing was carried out with tissue specimens from 40 prostate cancer (PCa) and 8 benign prostate hyperplasia patients. We identified two intergenic long non-coding transcripts, located in close genomic proximity, which are highly expressed in PCa. Microarray studies on a larger cohort comprising 155 patients showed a profound diagnostic potential of these transcripts (AUC~0.94), which we designated as tumor associated prostate cancer increased lncRNA (TAP...
Source: Cancers - April 29, 2020 Category: Cancer & Oncology Authors: Friedrich Wiedemann Reiche Puppel Pfeifer Zipfel Binder K öhl M üller Engeland Aigner F üssel Fr öhner Peitzsch Dubrovska Rade Christ Schreiber Hackerm üller Lehmann Toma Muders Sommer Baretton Wirth Horn Tags: Article Source Type: research

Knockdown of the co‐chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation
This study provides insight into the biological actions of SGTA, its effect on genome‐wide AR transcriptional activity and other therapeutically targeted intracellular signaling pathways, whilst also providing evidence for PCa‐specific alterations in SGTA expression. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - June 6, 2013 Category: Cancer & Oncology Authors: Andrew P. Trotta, Eleanor F. Need, Luke A. Selth, Samarth Chopra, Carole B. Pinnock, Damien A. Leach, Gerhard A Coetzee, Lisa M. Butler, Wayne D. Tilley, Grant Buchanan Tags: Cancer Cell Biology Source Type: research

The over‐expression of Pim‐2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B
CONCLUSIONPim‐2 was over‐expressed in PCA cell lines and tissues. It may inhibit the apoptosis of PCA cells through phosphorylating eIF4B, thus promote the tumorigenesis of PCA. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 27, 2013 Category: Urology & Nephrology Authors: Ke Ren, Xin Gou, Mingzhao Xiao, Ming Wang, Chaodong Liu, Zhaobing Tang, Weiyang He Tags: Original Article Source Type: research

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion.
Abstract SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer (PCa) tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia (BPH) tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PC...
Source: Asian Journal of Andrology - February 18, 2014 Category: Urology & Nephrology Authors: Sun Y, Wei M, Ren SC, Chen R, Xu WD, Wang FB, Lu J, Shen J, Yu YW, Hou JG, Xu CL, Huang JT, Sun YH Tags: Asian J Androl Source Type: research

Potential role of the OPG/RANK/RANKL axis in prostate cancer invasion and bone metastasis.
Authors: Li X, Liu Y, Wu B, Dong Z, Wang Y, Lu J, Shi P, Bai W, Wang Z Abstract Receptor activator of NF-κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are key regulators of bone metabolism under both normal and pathological conditions, including prostate cancer (PCa) bone metastases. However, little is known concerning the expression and function of these regulators in prostate tumor samples and PCa cells and their correlation with invasion and bone metastasis. In the present study, we determined the expression of RANK, RANKL and OPG in 3 human PCa cell lines and 40 PCa patient samples by immunohistoche...
Source: Oncology Reports - November 16, 2014 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation
Conclusions: We demonstrate a cross-talk between alpha1D-AR and TRPV1, that is involved in the control of PC3 cell proliferation. These data strongly support for a putative novel pharmacological approach in the treatment of PCa by targeting both alpha1D-AR and TRPV1 channels.
Source: BMC Cancer - December 7, 2014 Category: Cancer & Oncology Authors: Maria MorelliConsuelo AmantiniMassimo NabissiSonia LiberatiClaudio CardinaliValerio FarfarielloDaniele TomassoniWilma QuagliaAlessandro PiergentiliAlessandro BonifaziFabio Del BelloMatteo SantoniGabriele MammanaLucilla ServiAlessandra FilosaAngela Gismond Source Type: research

Inhibition of LDHA suppresses tumor progression in prostate cancer
Abstract A key hallmark of cancer cells is their altered metabolism, known as Warburg effect. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor progression. However, the function of LDHA in prostate cancer has not been studied. In current study, we observed overexpression of LDHA in the clinical prostate cancer samples compared with benign prostate hyperplasia tissues as demonstrated by immunohistochemistry and real-time qPCR. Attenuated expression of LDHA by siRNA or inhibition of LDHA activities by FX11 inhibited cell proliferation, mig...
Source: Tumor Biology - May 16, 2015 Category: Cancer & Oncology Source Type: research

27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells
In this study, we determined the effect of 27-OHC in human prostate epithelial cells RWPE-1. We found that 27-OHC stimulates proliferation and increases androgen receptor (AR) transcriptional activity. 27-OHC also increased prostate-specific antigen expression and enhanced AR binding to the androgen response element compared to controls. Silencing AR expression with siRNA markedly reduced the 27-OHC-induced proliferation. Furthermore, 27-OHC blocked docetaxel-induced apoptosis. Altogether, our results suggest that 27-OHC may play an important role in PCa and BPH progression by promoting proliferation and suppressing apoptosis.
Source: Medical Oncology - January 5, 2016 Category: Cancer & Oncology Source Type: research

Abstract A16: Different epigenetic mechanisms involved in the regulation of SFRP1 gene in prostate cancer
Among men, prostate cancer (PCa)[1] is the second most common cancer and the fifth cause of death worldwide [2]. Androgens play an important role in the development of the disease. For advanced PCa the standard therapy is androgen depletion. However, after 2 or 3 years a high percentage of patients become resistant to this therapy and castration resistant prostate cancer (CRPC) is developed. There is no successful treatment for CRPC, leading into death [3, 4]. Wingless pathway (WNT) is aberrantly activated in several cancer types and in PCa it is involved in AR activity modulation, promoting cancer development [5]. Secrete...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Garcia–Tobilla, P., Uribe, O., Rodriguez–Dorantes, M. Tags: Epigenetic Control of Transcription/ Elongation Source Type: research

SATB1 promotes prostate cancer metastasis by the regulation of epithelial–mesenchymal transition
In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on clinical prostate cancer samples. Silencing SATB1 inhibited the growth of DU-145 cells subcutaneous tumor in nude mice, while SATB1 overexpression promoted the growth of LNCaP cells subcutaneous tumor in nude mice. Immunohistochemical and Western blot analysis of the xenografts showed that silencing SATB1 led to decreased expression of vimentin and MMP2 and increased expression of E-cadherin, while SATB1 overexpr...
Source: Biomedicine and Pharmacotherapy - February 11, 2016 Category: Drugs & Pharmacology Source Type: research

SATB1 promotes prostate cancer metastasis by the regulation of epithelial-mesenchymal transition.
In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on clinical prostate cancer samples. Silencing SATB1 inhibited the growth of DU-145 cells subcutaneous tumor in nude mice, while SATB1 overexpression promoted the growth of LNCaP cells subcutaneous tumor in nude mice. Immunohistochemical and Western blot analysis of the xenografts showed that silencing SATB1 led to decreased expression of vimentin and MMP2 and increased expression of E-cadherin, while SATB1 overexpr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2016 Category: Drugs & Pharmacology Authors: Mao LJ, Yang CH, Fan L, Gao P, Yang DR, Xue BX, Zheng JN, Shan YX Tags: Biomed Pharmacother Source Type: research

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
This study supports an oncogenic role for CYP1A1 in prostate cancer via promoter hypomethylation that is influenced by tobacco smoking, indicating CYP1A1 to be a promising target for prostate cancer treatment. PMID: 27203547 [PubMed - as supplied by publisher]
Source: Oncotarget - May 21, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.
Authors: Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM, The Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC Abstract Proliferation and maintenance of both normal and prostate cancer (PCa) cells is highly regulated by steroid hormones, particularly androgens, and the extracellular environment. Herein, we identify the secretion of CD9 positive extracellular vesicles (EV) by LNCaP and DUCaP PCa cells in response to dihydrotestosterone (DHT) and use nano-LC-MS/MS to identify the proteins present in these EV. Subsequent bioinformatic and pathway anal...
Source: Oncotarget - August 16, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Role of connexin 43 in cadmium ‐induced proliferation of human prostate epithelial cells
In this study, the human prostate epithelial cell line RWPE‐1 was exposed to Cd. A low dose of Cd stimulated cell proliferation along with a lower degree of gap junction intercellular communication and an elevated level of the protein Cx43. Cd exposure increased the levels of intracellular Ca2+ and phosphorylated Cx43 at the Ser368 site. Knockdown of Cx43 using siRNA blocked Cd‐induced proliferation and interfered with the Cd‐induced changes in the protein levels of cyclin D1, cyclin B1, p27Kip1 (p27) and p21Waf1/Cip1 (p21). The increase in Cx43 expression induced by Cd was presumably mediated by the androgen recepto...
Source: Journal of Applied Toxicology - February 7, 2017 Category: Toxicology Authors: Qingping Liu, Xiaoli Ji, Zehe Ge, Haipeng Diao, Xiuli Chang, Lihua Wang, Qing Wu Tags: Research article Source Type: research