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Total 21 results found since Jan 2013.

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research

REM sleep and muscle atonia in brainstem stroke: A quantitative polysomnographic and lesion analysis study
This study reports on the impact of brainstem stroke on rapid eye movement atonia features in a human cohort. Our findings highlight the important role of the human brainstem, in particular the medioventral pontine regions, in the regulation of phasic muscle activity during rapid eye movement sleep and the ultradian distribution of rapid eye movement-related muscle activity.PMID:35609965 | DOI:10.1111/jsr.13640
Source: Journal of Sleep Research - May 24, 2022 Category: Sleep Medicine Authors: Nathalie Tellenbach Markus H Schmidt Filip Alexiev Eva Blondiaux Fabian Cavalloni Claudio L Bassetti Lukas Heydrich Panagiotis Bargiotas Source Type: research

Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment
Conclusion In this study, reduced CBF and FA and increased MD in the inner NAWM layers for both PVWMH and DWMH suggested extensive WM alterations beyond the visible WM lesions commonly observed on clinical MRI of svMCI subjects. CBF penumbras cover more extensive WM at risk than DTI penumbras, suggesting the likelihood that compromised CBF precedes white matter integrity changes, and CBF penumbras may be a potential target for the prevention of further microstructural white matter damage. The imaging parameters investigated, however, did not correlate to cognition. Author Contributions YZ, QX, and XG conceived and desig...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Functional MRI of Letter Cancellation Task Performance in Older Adults
Conclusion The present work is the first to identify neural correlates of the LCT using fMRI and tablet technology in a healthy aging population. Across all ages, the activation was found to be bilateral, including in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and various occipital and parietal areas. With increasing age, performance generally decreased and brain activity was reduced in the supplementary motor area, middle and inferior frontal gyrus, middle occipital gyrus, putamen and cerebellum. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and r...
Source: Frontiers in Human Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

Grey matter correlations of cognitive impairment in early parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation-parkinson's disease (icicle-pd) study
Conclusion GM loss is not present in newly diagnosed PD, either in patients with PD–MCI or PD–NC. These data are consistent with neuropathological studies suggesting that GM loss occurs with disease progression and is not prominent in early PD where the neurodegenerative process is more limited.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Duncan, G. W., Firbank, M. J., Yarnall, A. J., Barker, R. A., O'Brien, J. T., Burn, D. J. Tags: Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Octo Source Type: research

Selegiline promotes NOTCH-JAGGED signaling in astrocytes of the peri-infarct region and improves the functional integrity of the neurovascular unit in a rat model of focal ischemia.
CONCLUSION: Our results suggest that selegiline treatment enhances Notch-Jagged signaling in astrocytes, reduces peri-lesional edema and potentially helps preserve the capillary network following focal ischemia. PMID: 25361607 [PubMed - indexed for MEDLINE]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research.
Abstract It is well known that the brain is one of the organs particularly affected by aging in terms of function, relative to the gastrointestinal tract and liver, which exhibit less functional decline. There is also a wide range of age-related neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. Therefore, it is very important to understand the relationship between functional age-related change and neurological dysfunction. Neuroimaging techniques including magnetic resonance imaging and positron emission tomography have been significantly improved over recent years. Many physicia...
Source: Ageing Research Reviews - March 11, 2016 Category: Genetics & Stem Cells Authors: Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H Tags: Ageing Res Rev Source Type: research

Real-time functional magnetic resonance imaging neurofeedback in motor neurorehabilitation
Purpose of review: Recent developments in functional magnetic resonance imaging (fMRI) have catalyzed a new field of translational neuroscience. Using fMRI to monitor the aspects of task-related changes in neural activation or brain connectivity, investigators can offer feedback of simple or complex neural signals/patterns back to the participant on a quasireal-time basis [real-time-fMRI-based neurofeedback (rt-fMRI-NF)]. Here, we introduce some background methodology of the new developments in this field and give a perspective on how they may be used in neurorehabilitation in the future. Recent findings: The development ...
Source: Current Opinion in Neurology - July 2, 2016 Category: Neurology Tags: NEUROIMAGING: Edited by Stefan Kloppel Source Type: research

Correlation between qualitative balance indices, dynamic posturography and structural brain imaging in patients with progressive supranuclear palsy and its subtypes
Conclusions: While balance and radiological abnormalities were more severe in PSP-R, the qualitative and quantitative measurements of severity of balance in PSP-P rather than PSP-R was a better reflection of the pathology of the midbrain.
Source: Neurology India - July 4, 2016 Category: Neurology Authors: Shaik Afsar PashaRavi YadavMohan GaneshanJitender SainiAnupam GuptaM SandhyaPramod Kumar Pal Source Type: research

Symbol Digit Modalities Test adaptation for Magnetic Resonance Imaging environment: a systematic review and meta-analysis
Conclusions The present study allowed the identification of brain areas activated during the performance of the SDMT in healthy subjects, and therefore it will help understanding the differences in brain activation by this task in clinical populations. Moreover, it may guide future studies of therapeutic strategies and interventions in those populations.
Source: Multiple Sclerosis and Related Disorders - January 31, 2018 Category: Neurology Source Type: research

Cancers, Vol. 11, Pages 111: A Review on a Deep Learning Perspective in Brain Cancer Classification
uca Saba Jasjit S. Suri A World Health Organization (WHO) Feb 2018 report has recently shown that mortality rate due to brain or central nervous system (CNS) cancer is the highest in the Asian continent. It is of critical importance that cancer be detected earlier so that many of these lives can be saved. Cancer grading is an important aspect for targeted therapy. As cancer diagnosis is highly invasive, time consuming and expensive, there is an immediate requirement to develop a non-invasive, cost-effective and efficient tools for brain cancer characterization and grade estimation. Brain scans using magnetic resonanc...
Source: Cancers - January 18, 2019 Category: Cancer & Oncology Authors: Gopal S. Tandel Mainak Biswas Omprakash G. Kakde Ashish Tiwari Harman S. Suri Monica Turk John R. Laird Christopher K. Kwaku A. Annabel A. Ankrah N. N. Khanna B. K. Madhusudhan Luca Saba Jasjit S. Suri Tags: Review Source Type: research