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Condition: Osteoporosis
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Total 136 results found since Jan 2013.
Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1084-3888The human urea transporter SLC14A1 (HUT11/UT-B) has been suggested as a marker for the adipogenic differentiation of bone cells with a relevance for bone diseases. We investigated the function of SLC14A1 in different cells models from bone environment. SLC14A1 expression and cytokine production was investigated in bone cells obtained from patients with osteoporosis. Gene and protein expression of SLC14A1 was studied during adipogenic or osteogenic differentiation of human mesenchymal progenitor cells (hMSCs) and of the single-cell–derived hMSC line (SCP-1), as well as ...
Source: Experimental and Clinical Endocrinology and Diabetes - January 19, 2020 Category: Endocrinology Authors: Komrakova, Marina Blaschke, Martina Ponce, Maria Laura Kl üver, Anne K öpp, Regine H üfner, Michael Schieker, Matthias Miosge, Nicolai Siggelkow, Heide Tags: Article Source Type: research
Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - February 21, 2020 Category: Orthopaedics Authors: Yi Peng,
Shan Lv,
Yusheng Li,
Jianxi Zhu,
Shijie Chen,
Gehua Zhen,
Xu Cao,
Song Wu,
Janet L. Crane Tags: Original Article Source Type: research
Tissue inhibitor of metalloproteinase 1 suppresses growth and differentiation of osteoblasts and differentiation of osteoclasts by targeting the AKT pathway.
In conclusion, our results demonstrate that TIMP1 can act as a suppressor of growth and differentiation of osteoblasts and differentiation of osteoclasts through the negative regulation of the AKT pathway. We propose that TIMP1 may serve as a potential target for low bone mass-related skeletal diseases, such as osteoporosis.
PMID: 32113948 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - February 26, 2020 Category: Cytology Authors: Xi Y, Huang H, Zhao Z, Ma J, Chen Y Tags: Exp Cell Res Source Type: research
Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 12, 2020 Category: Orthopaedics Authors: Yi Peng,
Shan Lv,
Yusheng Li,
Jianxi Zhu,
Shijie Chen,
Gehua Zhen,
Xu Cao,
Song Wu,
Janet L. Crane Tags: Original Article Source Type: research
Effect of lncRNA AK023948 on rats with postmenopausal osteoporosis via PI3K/AKT signaling pathway.
CONCLUSIONS: LncRNA AK0 can regulate the phosphorylation level of AKT in osteoblasts of rats with estrogen deficiency-related osteoporosis through the PI3K/AKT signaling pathway, thus regulating the proliferation of osteoblasts. It is speculated that lncRNA AK0 may be an important factor in regulating the PI3K/AKT signaling pathway.
PMID: 32196569 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 30, 2020 Category: Orthopaedics Authors: Yi Peng,
Shan Lv,
Yusheng Li,
Jianxi Zhu,
Shijie Chen,
Gehua Zhen,
Xu Cao,
Song Wu,
Janet L. Crane Tags: Original Article Source Type: research
Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.
This study confirmed that astragalus could inhibit the aging of BMSCs and improve the osteogenesis ability by regulating the VD-FGF23-Klotho pathway. This study provided a certain research basis for the therapeutic of traditional Chinese medicine (TCM) on primary osteoporosis.
PMID: 32355520 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - May 3, 2020 Category: Pathology Authors: Pu X, Chai Y, Guan L, Li W, Gao J, Jiang Z, Li Q, Wu Y, Chen Y Tags: Int J Clin Exp Pathol Source Type: research
An emerging potential therapeutic target for osteoporosis: LncRNA H19/miR-29a-3p axis
This study might provide a better understanding of OP development and a potential therapeutic target for OP intervention.
Source: European Journal of Histochemistry - October 19, 2020 Category: Biomedical Science Authors: Ziqi Li, Zhinan Hong, Yuesheng Zheng, Yongwei Dong, Wei He, Yingjia Yuan, Junbiao Guo Source Type: research
Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice.
In this study, we found that AGR inhibited RANKL-induced osteoclastogenesis, bone-resorption, F-actin ring formation, and the mRNA expression of osteoclast-associated genes such as CTSK, TRAP, MMP-9, and ATP6v0d2 in vitro. In addition, AGR suppressed RANKL-induced expression of c-Fos and NFATc1. However, AGR treatment did not affect NF-κB activation and MAPKs phosphorylation in RANKL-stimulated BMMs, which implicated that AGR might not influence the initial expression of NFATc1 mediated by NF-κB and MAPKs signaling. Our results further indicated that AGR did not alter phosphorylation levels of GSK3β and the expression o...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Cao J, Wang S, Wei C, Lin H, Zhang C, Gao Y, Xu Z, Cheng Z, Sun WC, Wang HB Tags: Int Immunopharmacol Source Type: research
The miR-187 induced bone reconstruction and healing in a mouse model of osteoporosis, and accelerated osteoblastic differentiation of human multipotent stromal cells by targeting BARX2
CONCLUSIONS: The miR-187 might have a significant therapeutic effect in osteoporotic fractures. miR-187 accelerated osteogenic differentiation of hMSCs by directly regulating BARX2.PMID:33550149 | DOI:10.1016/j.prp.2021.153340
Source: Pathology, Research and Practice - February 7, 2021 Category: Pathology Authors: Jun Zhang Tao Zhang Bensen Tang Jing Li Zhengang Zha Source Type: research
Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells by regulating TP63
CONCLUSIONS: Our results indicate that GluOC reduces the inhibitory effect of high glucose on osteoblast differentiation by regulating the TP63/PTEN/Akt/GSK3β pathway. TP63 is a potential novel target for the prevention and treatment of diabetic osteoporosis.PMID:33906607 | DOI:10.1186/s12860-021-00365-7
Source: Mol Biol Cell - April 28, 2021 Category: Molecular Biology Authors: Fangzi Gong Le Gao Luyao Ma Guangxin Li Jianhong Yang Source Type: research
Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production
In conclusion, our data demonstrated a novel mechanism involving in the production of PDGF-BB increased by harmine, which may provide potential therapeutic targets for bone loss diseases.PMID:33960660 | DOI:10.1111/jcmm.16562
Source: J Cell Mol Med - May 7, 2021 Category: Molecular Biology Authors: Jie Huang You-You Li Kun Xia Yi-Yi Wang Chun-Yuan Chen Meng-Lu Chen Jia Cao Zheng-Zhao Liu Zhen-Xing Wang Hao Yin Xiong-Ke Hu Zheng-Guang Wang Yong Zhou Hui Xie Source Type: research
