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Specialty: Endocrinology
Condition: Hypertension

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Total 255 results found since Jan 2013.

Effects of restoring normoglycemia in type 1 diabetes on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation
Patients with type 1 diabetes have increased risk of macrovascular complications such as atherosclerotic cardiovascular diseases including myocardial dysfunction and stroke [1,2], as well as microvascular complications including neuropathy, retinopathy and nephropathy [3]. Diabetic nephropathy is characterized by hypertension, albuminuria, reduced glomerular filtration rate (GFR) and kidney morphological changes [4]. These overt effects are the long-term consequences of changes in several important signaling systems affected by hyperglycemia [5], by changes in the renin-angiotensin system, increased transforming growth fac...
Source: Diabetes Research and Clinical Practice - October 27, 2014 Category: Endocrinology Authors: Trine Marita Reine, Ingrid Benedicte Moss Kolseth, Astri Jeanette Meen, Jørn Petter Lindahl, Trond Geir Jenssen, Finn Per Reinholt, Joseph Zaia, Chun Shao, Anders Hartmann, Svein Olav Kolset Source Type: research

Insulin resistance and beat-to-beat cardiovascular dynamics: a constant relationship across different body mass index and blood pressure categories.
Conclusions: These findings indicate that even small increases in HOMA index (not necessarily in the range to define insulin resistance) may induce significant changes on indices of cardiovascular function even in normal weight and normotensive subjects, emphasizing the importance of insulin resistance at an early stage of the cardiovascular risk continuum. PMID: 25329765 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 20, 2014 Category: Endocrinology Authors: Eugenio Ochoa J, Alberto Gallo J, Maria Correa M, Zapata N, Guillermo McEwen J, Bilo G, Aristizabal D, Parati G Tags: J Clin Endocrinol Metab Source Type: research

Differential Association Between Biomarkers of Subclinical Inflammation and Painful Polyneuropathy: Results From the KORA F4 Study.
CONCLUSIONS: Painful DSPN is linked to systemic subclinical and vascular inflammation in the older population independent of anthropometric, lifestyle, and metabolic confounders. PMID: 25325880 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 16, 2014 Category: Endocrinology Authors: Herder C, Bongaerts BW, Rathmann W, Heier M, Kowall B, Koenig W, Thorand B, Roden M, Meisinger C, Ziegler D Tags: Diabetes Care Source Type: research

Association between high sensitivity C-reactive protein and metabolic syndrome in subjects completing the National Health and Nutrition Examination Survey (NHANES) 2009–10
Conclusions Presence of metabolic syndrome was common in subjects from NHANES 2009–10 and a significant “dose-related” association was confirmed between number of metabolic syndrome conditions and increasing odds of elevated hs-CRP concentration.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - October 12, 2014 Category: Endocrinology Source Type: research

Role of Comorbidities as Limiting Factors to the Effect of Hyperbaric Oxygen in Diabetic Foot Patients: A Retrospective Analysis
Conclusions Diabetic foot patients with histories of coronary artery diseases or stroke and non-proliferative or proliferative retinopathy might resist HBOT. PAD at the femoral arterial level has been shown to have a significant negative effect on HBOT outcomes that should be first considered for surgery. In contrast, PAD below the knee does not seem to be an obstacle to the efficacy of HBOT.
Source: Diabetes Therapy - October 2, 2014 Category: Endocrinology Source Type: research

Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease.
Abstract Endothelial nitric oxide synthase (eNOS or NOS3), an enzyme constitutively expressed especially in endothelial cells, is largely responsible for nitric oxide (NO) bioavailability at the endothelial level. Alterations in endothelial-derived NO production have been associated with various diseases, and, in humans, can be genetically determined by the presence of different polymorphisms in the eNOS gene. To date, the most studied and functionally related polymorphisms are: Glu298Asp (rs1799983), -786T/C (rs2070744), and the intron 4 variable number tandem repeat. Evidence supports a major role of these varia...
Source: Vitamins and Hormones - September 9, 2014 Category: Endocrinology Authors: Vecoli C Tags: Vitam Horm Source Type: research

GLP-1R activation for the treatment of stroke: Updating and future perspectives
Abstract Stroke is the leading cause of adult disability in Westernized societies with increased incidence along ageing and it represents a major health and economical threat. Inactive lifestyle, smoking, hypertension, atherosclerosis, obesity and diabetes all dramatically increase the risk of stroke. While preventive strategies based on lifestyle changes and risk factor management can delay or decrease the likelihood of having a stroke, post stroke pharmacological strategies aimed at minimizing stroke-induced brain damage are highly needed. Unfortunately, several candidate drugs that have shown significant precl...
Source: Reviews in Endocrine and Metabolic Disorders - September 1, 2014 Category: Endocrinology Source Type: research

Risk of New‐onset Diabetes after Androgen Deprivation Therapy for Prostate Cancer in the Asian Population
ConclusionsThere was increased risk of new‐onset DM after ADT for prostate cancer in the Asian population. Regular screening of DM can be considered after the initiation of ADT, especially in patients with known history of dyslipidemia and impaired fasting glucose.
Source: Journal of Diabetes - September 1, 2014 Category: Endocrinology Authors: Jeremy Yuen Chun Teoh, Peter Ka Fung Chiu, Samson Yun Sang Chan, Darren Ming Chun Poon, Ho‐Yuen Cheung, Simon See Ming Hou, Chi‐Fai Ng Tags: Original Article Source Type: research

Gender differences and patterns of cardiovascular risk factors in Type 1 and Type 2 diabetes: a population‐based analysis from a Scottish region
ConclusionsThe study shows gender differences between Type 1 and 2 diabetes that are of clinical significance and require further investigation. Follow‐up of the patients included in the present study should give us much greater understanding of the importance of gender in the development of metabolic abnormalities and diabetes complications.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - August 23, 2014 Category: Endocrinology Authors: A. Collier, S. Ghosh, M. Hair, N. Waugh Tags: Research Article Source Type: research

Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients.
CONCLUSION: We failed to show an association between vitamin D, apelin and MPV higher volumes of which may have a role in cardiovascular complications related to diabetes by increasing platelet activation. PMID: 25156130 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - August 22, 2014 Category: Endocrinology Authors: Kiskac M, Zorlu M, Cakirca M, Karatoprak C, Kesgin S, Büyükaydın B, Yavuz E, Ardic C, Camli AA, Cikrikcioglu MA Tags: Ann Endocrinol (Paris) Source Type: research

Haptoglobin genotype and cerebrovascular disease incidence in type 1 diabetes
Conclusion: Despite the protective effect against vascular diabetes complications, a borderline increased risk of stroke was observed with Hp 1-1 in type 1 diabetes. This mixed Hp effect on cardiovascular risk by outcome studied merits further investigation and cautions against the universal application of preventive therapies across all Hp genotypes.
Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Costacou, T., Secrest, A. M., Ferrell, R. E., Orchard, T. J. Tags: Original Articles Source Type: research

Endothelial NADPH oxidases: which NOX to target in vascular disease?
Abstract NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes implicated in the pathophysiology of vascular diseases such as hypertension and stroke. Endothelial cells express four NOX isoforms including the superoxide-generating enzymes NOX1, NOX2, and NOX5 and the hydrogen peroxide-generating enzyme NOX4. Studies on arteries from patients with coronary artery disease, and in animals with experimentally induced hypertension, diabetes, or atherosclerosis, suggest that NOX1, NOX2, and NOX5 promote endothelial dysfunction, inflammation, and apoptosis in the vessel wall, whereas NOX4 is by contr...
Source: Trends in Endocrinology and Metabolism: TEM - July 22, 2014 Category: Endocrinology Authors: Drummond GR, Sobey CG Tags: Trends Endocrinol Metab Source Type: research

Effects of fasting blood glucose levels and blood pressure and treatment of diabetes and hypertension on the incidence of cardiovascular disease: a study of 740 patients with incident Type 2 diabetes with up to 30 years’ follow‐up
ConclusionsThe cumulative incidence of cardiovascular disease and myocardial infarction increased with number of previous events and presence of hyperglycaemia and hypertension and decreased with pharmacological treatment of diabetes. A higher number of previous stroke events increased the cumulative incidence of stroke but no protective effect of pharmacological treatment was observed.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - June 1, 2014 Category: Endocrinology Authors: S.P.O. Jansson, D.K.G. Andersson, K. Svärdsudd Tags: Research Article Source Type: research

GLP-1R activation for the treatment of stroke: Updating and future perspectives.
Abstract Stroke is the leading cause of adult disability in Westernized societies with increased incidence along ageing and it represents a major health and economical threat. Inactive lifestyle, smoking, hypertension, atherosclerosis, obesity and diabetes all dramatically increase the risk of stroke. While preventive strategies based on lifestyle changes and risk factor management can delay or decrease the likelihood of having a stroke, post stroke pharmacological strategies aimed at minimizing stroke-induced brain damage are highly needed. Unfortunately, several candidate drugs that have shown significant precli...
Source: ENDOCR REV - April 30, 2014 Category: Endocrinology Authors: Darsalia V, Nathanson D, Nyström T, Klein T, Sjöholm A, Patrone C Tags: Rev Endocr Metab Disord Source Type: research

Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan.
Conclusion: People diagnosed with OSA are at increased risk for subsequent osteoporosis. PMID: 24735427 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - April 15, 2014 Category: Endocrinology Authors: Chen YL, Weng SF, Shen YC, Chou CW, Yang CY, Wang JJ, Tien KJ Tags: J Clin Endocrinol Metab Source Type: research