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Condition: Hemorrhagic Stroke
Therapy: Statin Therapy

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Total 361 results found since Jan 2013.

Statins and ICH: New Meta-Analysis Statins and ICH: New Meta-Analysis
A new meta-analysis has concluded that the benefit of statin therapy in the prevention of ischemic stroke ' greatly exceeds ' the risk for intracerebral hemorrhage (ICH).Medscape Medical News
Source: Medscape Pathology Headlines - May 4, 2020 Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news

Medical Management for Secondary Stroke Prevention
This article reviews the evidence base and recommendations for medical management for secondary stroke prevention. RECENT FINDINGS Recent developments for secondary stroke prevention include evidence to support the use of short-term dual antiplatelet therapy after minor stroke and transient ischemic attack, direct oral anticoagulants for nonvalvular atrial fibrillation, reversal agents for direct oral anticoagulant–associated hemorrhage, and aspirin rather than presumptive anticoagulation with a direct oral anticoagulant for embolic stroke of undetermined source. SUMMARY Most strokes are preventable. The mainstays ...
Source: CONTINUUM: Lifelong Learning in Neurology - April 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: a systematic review and meta-analysis of 33 randomized controlled trials.
Authors: Cheng Y, Qiao L, Jiang Z, Dong X, Feng H, Gui Q, Lu Y, Liang Y Abstract The dose-dependent pleiotropic effects of statin therapy may have unwanted side effects such as increasing the risk of intracerebral hemorrhage (ICH). The relationships among statin therapy, LDL-cholesterol levels, and ICH risk remain controversial. Here, we conduct a systematic review and meta-analysis of dose-dependent statin therapy and ICH risk. Eligible articles were identified by searching MEDLINE from inception up to December 1, 2018. Reference lists of previous meta-analyses were manually searched to retrieve all relevant publi...
Source: American Journal of Translational Research - March 22, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Temporal Trends and Patient Characteristics Associated With Drug Utilisation After First-Ever Stroke: Insights From Chronic Disease Registry Data in Singapore.
CONCLUSION: This study reveals changes in prescription behaviour over time in a multiethnic Asian population with first-ever stroke. Patient characteristics including younger age, Malay ethnicity and certain comorbidities (i.e. hyperlipidaemia, atrial fibrillation) were associated with the combined use of all 3 guideline medications among ischaemic stroke patients. PMID: 32301477 [PubMed - in process]
Source: Ann Acad Med Singapo... - February 29, 2020 Category: General Medicine Authors: Yeo SH, Toh MPH, Lee SH, Seet RC, Wong LY, Yau WP Tags: Ann Acad Med Singapore Source Type: research

Clinical burden of autosomal dominant polycystic kidney disease.
Abstract There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individually selected patients with and without ADPKD from inpatient data files as well as from the catastrophic illness registry in Taiwan based on 1:5 frequency matching for sex, age, and index year. The hazard ratios (HR) of all-cause mortality, ischemic stroke, hemorrhagic stroke and end-stage ren...
Source: Aging - February 23, 2020 Category: Biomedical Science Authors: Hung PH, Lin CH, Hung KY, Muo CH, Chung MC, Chang CH, Chung CJ Tags: Aging (Albany NY) Source Type: research

Eicosapentaenoic-to-Arachidonic Acid Ratio Predicts Mortality and Recurrent Vascular Events in Ischemic Stroke Patients.
CONCLUSIONS: Low EPA/AA ratio at baseline and treatment without statins could predict mortality, recurrent ischemic stroke, cardiovascular and peripheral artery diseases, and hemorrhagic stroke among patients with acute ischemic stroke. The combination of baseline EPA/AA ratio and statin therapy could be critical in predicting the long-term prognosis of ischemic stroke patients. PMID: 31969533 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - January 25, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance.
Authors: Zheng M, Wang X, Yang J, Ma S, Wei Y, Liu S Abstract Changes of complement and oxidative stress parameters in patients with acute cerebral infarction (ACI) or cerebral hemorrhage (CH), and their clinical significance were explored. A total of 122 patients with ACI or CH admitted to the People's Hospital of Zhangqiu Area from August 2018 to September 2019 were collected. There were 59 ACI patients assigned into a cerebral infarction group (CIG) and further 63 CH patients in a cerebral hemorrhage group (CHG). Additionally, 53 healthy people in physical examination during the same period were enrolled as a co...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Management of Hyperlipidemia After Stroke
AbstractPurpose of reviewHyperlipidemia is a key therapeutic target for stroke risk modification. The goal of this review is to highlight available treatment options and review their efficacy in the setting of general cardiovascular disease and after most subtypes of ischemic stroke and hemorrhagic stroke.Recent findingsStatins remain first-line in the management of hyperlipidemia to prevent stroke. In recent trials of patients with pre-existing atherosclerotic vascular disease, new agents, most notably PCSK9 inhibitors and ezetimibe, added additional stroke risk reduction when combined with statins.SummaryRisk of stroke c...
Source: Current Treatment Options in Cardiovascular Medicine - December 15, 2019 Category: Cardiology Source Type: research

Statin Na ïve Patients with Myocardial Infarction have more Echolucent Plaques Compared to Long-term Statin Treated Chronic Atherosclerotic Patients – A 3D Ultrasound Study
Introduction: Size and morphology of carotid atherosclerotic plaques can be quantified by ultrasound (US) imaging. Carotid artery plaque size and gray-scale median (GSM) have been identified as risk markers for both cardiovascular events and stroke ADDIN EN.CITE ADDIN EN.CITE.DATA (1, 2). Unstable plaques have a thin fibrotic cap and a lipid or hemorrhagic core ADDIN EN.CITE ADDIN EN.CITE.DATA (3-6). A higher amount of lipid and hemorrhage have been observed in echolucent carotid plaques presenting as lower GSM compared to echogenic carotid plaques containing fibrotic tissue and calcification ADDIN EN.CITE ADDIN EN.CITE.DATA (7-10).
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: L ærke Urbak, Benjamin Sandholt, Martin Graebe, Lia E. Bang, Henning Bundgaard, Henrik Sillesen Source Type: research

Management Protocols and Encountered Complications among Stroke Patients Admitted to Stroke Unit of Jimma University Medical Center, Southwest Ethiopia: Prospective Observational study
ConclusionBoth neurologic and medical complications were common in majority of stroke patients. But the management protocol for stroke patients was sub-optimal and lagging behind the recommended guidelines due to lack of skilled personnel, appropriate treatment and diagnostic agents. The clinical team involved in the care of stroke patients should make preparations to take preventive measures that will save a lot of lives.
Source: Annals of Medicine and Surgery - November 15, 2019 Category: General Medicine Source Type: research

The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research

The effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation
Publication date: Available online 11 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yousheng Wu, Dan Lu, Anding XuAbstractThrombolysis-induced haemorrhagic transformation is the most challenging preventable complication in thrombolytic therapy. This condition is often associated with poor functional outcome and long-term disease burden. Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are controversially suggested to either increase or decrease the odds of better primary outcomes compared to treatment without statins after thrombolysis in patients or animals; statins are ...
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

The Benefits and Risks of Statin Therapy in Ischemic Stroke: A Review of the Literature
Wang Zhao, Zhi-Jie Xiao, Shui-Ping ZhaoNeurology India 2019 67(4):983-992 Statins are effective cholesterol-lowering drugs for reducing the risks of mortality and morbidity of cardiovascular diseases. Increasing evidence has shown that statin use is associated with a significant beneficial effect in patients with ischemic stroke. Both pre-stroke and post-stroke statin use has been found to be beneficial in ischemic stroke. Furthermore, good adherence is associated with a better clinical outcome, and statin withdrawal is associated with a poor functional outcome in patients with ischemic stroke. High-intensity statin thera...
Source: Neurology India - September 9, 2019 Category: Neurology Authors: Wang Zhao Zhi-Jie Xiao Shui-Ping Zhao Source Type: research

Adjunctive statin therapy reduces intracranial hemorrhage and 1-year mortality in patients with atrial fibrillation after acute ischemic stroke: A population-based epidemiological study from Taiwan
ConclusionsStatin therapy reduced the risk of ICH and 1-year mortality in AF patients who experienced acute ischemic stroke.
Source: Journal of Clinical Neuroscience - July 20, 2019 Category: Neuroscience Source Type: research

Temporal Trends and Predictors of Drug Utilization and Outcomes in First-Ever Stroke Patients: A Population-Based Study Using the Singapore Stroke Registry
ConclusionsPrescription of secondary stroke preventive medications (particularly in ischemic stroke) was associated with more favorable outcomes, highlighting the importance of physician adherence to evidence-based pharmacotherapy.
Source: CNS Drugs - July 15, 2019 Category: Neurology Source Type: research