Clinical burden of autosomal dominant polycystic kidney disease.
Clinical burden of autosomal dominant polycystic kidney disease. Aging (Albany NY). 2020 Feb 24;12: Authors: Hung PH, Lin CH, Hung KY, Muo CH, Chung MC, Chang CH, Chung CJ Abstract There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individually selected patients with and without ADPKD from inpatient data files as well as from the catastrophic illness registry in Taiwan based on 1:5 frequency matching for sex, age, and index year. The hazard ratios (HR) of all-cause mortality, ischemic stroke, hemorrhagic stroke and end-stage renal disease (ESRD) in ADPKD inpatients were elevated as compared to the controls. Similarly, ADPKD patients from the catastrophic illness registry had an increased risk of hemorrhagic stroke and ESRD. Allopurinol users also had an increased risk of all-cause mortality. The HR for developing ESRD after medication exposure was 0.47-fold for statin and 1.93-fold for pentoxifylline. These results reveal that patients with ADPKD (either inpatient or from the catastrophic illness registry) are at elevated risk for hemorrhagic stroke and ESRD, and suggest that allopurinol and pentoxifylline should not be prescribed to ADPKD patients due to possible adverse effects. PMID: 32096480...
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (= 1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
At any given time, more than a third of Americans are on a specific diet, with weight loss as a leading reason. Most are going to be disappointed, because even when successful, lost weight is frequently regained within a few months. While most weight-loss diets can help you lose weight, they may be unsuccessful over the long run for a number of reasons. Some people don’t follow their diets carefully and don’t lose much weight even from the start. Others may go off the diet entirely after a while, because it’s too restrictive or the foods aren’t appealing. Some may engage in less physical activity as...
CONCLUSION: As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction. PMID: 32444531 [PubMed - as supplied by publisher]
Conditions: Stroke; Sleep-disordered Breathing; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Sleep Apnea, Central; Fragmentation, Sleep Intervention: Device: Treatment according to standard care recommandation Sponsor: University Hospital, Grenoble Not yet recruiting
Conditions: Stroke; Activities of Daily Living Interventions: Behavioral: Approach-Instrumental Activities of Daily Living; Behavioral: Home rehabilitation Sponsor: National Taipei University of Nursing and Health Sciences Recruiting
How prevalent is statin use among terminally ill nursing home residents? Should statins be discontinued in those unlikely to benefit from continued use?Journal of the American Geriatrics Society
Publication date: Available online 23 May 2020Source: Neurología (English Edition)Author(s): V. Montalván Ayala, Z. Rojas Cheje, R. Aldave Salazar
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher]
Publication date: Available online 24 May 2020Source: Neuroscience ResearchAuthor(s): Xiaowen Shi, Yasuyuki Ohta, Yumiko Nakano, Xia Liu, Koh Tadokoro, Tian Feng, Emi Nomura, Keiichiro Tsunoda, Ryo Sasaki, Namiko Matsumoto, Yosuke Osakada, Yuting Bian, Zhihong Bian, Omote Yoshio, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe