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Condition: Ischemic Stroke
Nutrition: Vitamin A

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Total 249 results found since Jan 2013.

Retinal Microvascular Changes in Subtypes of Ischemic Stroke
Conclusion: Retinal MVD0.5−1.0DD (>82.23 μm) might be associated with the AT stroke subtype; however, we need large-scale prospective studies in future to explore the underlying mechanism and causal explanation for this finding.
Source: Frontiers in Neurology - January 27, 2021 Category: Neurology Source Type: research

Retina as a window to cerebral dysfunction following studies with circRNA signature during neurodegeneration
Conclusions: This study provides molecular evidence that the retina is window of the brain from circRNA perspective. cGLIS3 is a common regulator and diagnostic marker of cerebral neurodegeneration and retinal neurodegeneration.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Qin Jiang, Dong-Yuan Su, Zhen-Zhen Wang, Chang Liu, Ya-Nan Sun, Hong Cheng, Xiu-Miao Li, Biao Yan Tags: Research Paper Source Type: research

Aneurysms in primary antiphospholipid syndrome: a case-based review
This article review ed all published cases on APS and aneurysm and showed that women who presented with abortions and deep venous thromboses with a lupus anticoagulant are those patients more commonly affected by aneurysms in APS.
Source: Clinical Rheumatology - January 3, 2021 Category: Rheumatology Source Type: research

Variations in the Presence of Carotid Intraplaque Hemorrhage Across Age Categories: What Age Groups Are Most Likely to Benefit From Plaque Imaging?
Although carotid artery intraplaque hemorrhage (IPH) is a known risk-factor for cerebral ischemic events in patients of advanced age, its prevalence in younger cohorts is less certain. The purpose of this study was to assess the prevalence of carotid artery IPH across the age spectrum. A retrospective review was completed of all adult patients from our institution who underwent neck MRA with high-resolution carotid plaque imaging between 2017 and 2020. The mean ages of patients with and without IPH were calculated. The prevalence of IPH was compared between patients that were categorized into age groups. Patients with and ...
Source: Frontiers in Neurology - December 14, 2020 Category: Neurology Source Type: research

Management of Acute Central Retinal Artery Occlusion, a “Retinal Stroke”: An Institutional Series and Literature Review
Acute central retinal artery occlusion (CRAO) is an ophthalmologic emergency that often results in permanent vision loss. Over 25% are associated with acute cerebral ischemia. In the absence of existing Level I treatment options, this study aims to examine institutional practice patterns and review the literature to develop a formalized approach to the treatment of CRAO in the era of ischemic stroke protocols.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: Katriel E. Lee, Christine Tschoe, Stephanie A. Coffman, Carol Kittel, Patrick A. Brown, Quang Vu, Kyle M. Fargen, Bartlett H. Hayes, Stacey Q. Wolfe Source Type: research

Secondary Stroke Prevention and Management for the Neuro-Ophthalmologist
Conclusions: The optimal treatment to prevent stroke recurrence is determined by the etiology of stroke. After stroke workup, patients will typically be placed on proper medical therapy for the appropriate duration in addition to counseling on lifestyle modifications to reduce the risk of recurrent strokes. For complex patients, it is reasonable for providers to consider patient referral to stroke specialists for further aid in selection of appropriate medical therapy.
Source: Journal of Neuro-Ophthalmology - November 22, 2020 Category: Opthalmology Tags: Disease of the Year 2020: Cerebrovascular Disorders Source Type: research

Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy
AbstractTraumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or direct injury to the optic nerve following blunt head trauma. TON is associated with increased oxidative stress and inflammation resulting in retinal ganglion cell (RGC) death. Remote ischemic post-conditioning (RIC) has been shown to enhance endogenous protective mechanisms in diverse disease models including stroke, vascular cognitive impairment (VCI), retinal injury and optic nerve injury. However, the protective mechanisms underlying the improvement of retinal function and RGC survival after RIC treatment remain unclear. H...
Source: NeuroMolecular Medicine - November 13, 2020 Category: Neurology Source Type: research

Janssen Submits Application to U.S. FDA for New Indication to Expand Use of XARELTO ® (rivaroxaban) in Patients with Peripheral Artery Disease
RARITAN, NJ, October 26, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for a new indication to expand the use of XARELTO® (rivaroxaban) in patients with peripheral artery disease (PAD). If approved, this new indication for the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 75-100 mg once daily) would include reducing the risk of major thrombotic vascular events such as heart attack, stroke and amputation in patients after recent lower-extremity revascularization, a c...
Source: Johnson and Johnson - October 26, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Retinal artery occlusion and risk of stroke
We read with interest the article of Laczynski et  al1 titled “Retinal artery occlusion does not portend an increased risk of stroke.” This retrospective study including 221 cases of ischemic retinal artery occlusion (RAO) showed an incidence of stroke of 2.3%. The authors concluded with the following statement: “The risk of stroke subsequen t to a confirmed episode of symptomatic RAO is very low.”1
Source: Journal of Vascular Surgery - October 21, 2020 Category: Surgery Authors: Matteo Fallico, Andrew Lotery, Michele Reibaldi Tags: Letter to the Editor Source Type: research

Predictive Factors for Pre-operative Recurrence of Cerebrovascular Symptoms in Symptomatic Carotid Stenosis.
CONCLUSION: More than every tenth patient with sCS experienced an early recurrent cerebrovascular event prior to scheduled CEA, despite optimal medication. However, stroke recurrence was lower than in earlier observational studies, which could be explained by improved care pathways, more aggressive medication, and expedited CEA. All recurrent strokes occurred in patients initially presenting with minor stroke. PMID: 33039297 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - October 7, 2020 Category: Surgery Authors: Eriksson H, Koskinen S, Nuotio K, Heikkilä HM, Vikatmaa P, Silvennoinen H, Valanne L, Mäyränpää MI, Kovanen PT, Soinne L, Lindsberg PJ, Ijäs P Tags: Eur J Vasc Endovasc Surg Source Type: research

Standard Diffusion-weighted MRI for the Diagnosis of Central Retinal Artery Occlusion
ConclusionsRetinal diffusion restrictions were present in a  majority of CRAO patients and detectable with reasonable sensitivity, high specificity and substantial inter-rater reliability. Further studies are necessary to study time dependency of retinal diffusion restrictions, improve image quality and investigate the reliability of retinal DWI to discern CRAO from other causes of acute loss of vision.
Source: Klinische Neuroradiologie - September 15, 2020 Category: Radiology Source Type: research

The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review
Conclusions: Changes in retinal microvasculature identified using OCTA are associated with monogenic SVD and different stages of AD, but data are limited and partly confounded by methodological differences. Larger studies with risk factors adjustment and more consistent OCTA methods are needed to fully exploit this technology.PROSPERO registration number: CRD42020166929.
Source: Frontiers in Neurology - September 9, 2020 Category: Neurology Source Type: research

The potential role of microvascular pathology in the neurological manifestations of coronavirus infection
We present the hypothesis that pre-existing vascular damage (due to aging, cardiovascular disease, diabetes, hypertension or other conditions) facilitates infiltration of the virus into the central nervous system (CNS), increasing neuro-inflammation and the likelihood o f neurological symptoms. We also discuss the role of a neuroinflammatory cytokine profile in both blood–brain barrier dysfunction and macrovascular disease (e.g. ischemic stroke and thromboembolism). Future studies are needed to better understand the involvement of the microvasculature in coronavi rus neuropathology, and to test the diagnostic potential o...
Source: Fluids and Barriers of the CNS - September 9, 2020 Category: Neuroscience Source Type: research

Retinal layers and visual conductivity changes in a case series of microangiopathic ischemic stroke patients
The objectives of this prospective non-interv...
Source: BMC Neurology - September 3, 2020 Category: Neurology Authors: John-Ih Lee, Lena Gemerzki, Margit Weise, Laura Boerker, Jonas Graf, Lea Jansen, Rainer Guthoff, Orhan Aktas, Michael Gliem, Sebastian Jander, Hans-Peter Hartung and Philipp Albrecht Tags: Research article Source Type: research

Neurovascular Causes of Acute Monocular Visual Loss
AbstractPurpose of reviewAcute monocular visual loss may result from a diverse set of neurovascular and systemic disorders and requires urgent evaluation. The goal of this review is to describe the most current understanding of the clinical features, pathophysiology, diagnosis, and treatment of these disorders.Recent findings1. Acute central retinal artery occlusion (CRAO) should be treated as an equivalent to acute ischemic stroke.2. Several recent clinical trials are evaluating the treatment of non-arteritic anterior ischemic optic neuropathy (NAION).3. Tocilizumab is emerging as a first-line steroid-sparing immunomodula...
Source: Current Treatment Options in Cardiovascular Medicine - September 1, 2020 Category: Cardiology Source Type: research