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Condition: Ischemic Stroke
Drug: Diprivan

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Total 35 results found since Jan 2013.

Comparison of the effect of propofol and desflurane on S-100β and GFAP levels during controlled hypotension for functional endoscopic sinus surgery: A randomized controlled trial
Conclusion: On comparing the effects of propofol and desflurane anesthesia for controlled hypotension on the levels of S-100β and GFAP, we noted that there was no significant difference in S-100β and GFAP levels between the 2 study groups. Clinical trial registration: Available at: http://cris.nih.go.kr, KCT0002698.
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke
In this study, propofol administration significantly reduced the neurotoxic aggregation of α-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demo nstrated that the propofol-induced reduction of α-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke.
Source: Neuroscience Bulletin - September 12, 2019 Category: Neuroscience Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy —A Matched Pair Analysis
ConclusionAn SOP using a novel sedation regimen and optimization of equipment and procedures directed at a leaner, more integrative and compact periinterventional management can reduce in-house treatment delays significantly in stroke patients receiving thrombectomy in light sedation and demonstrated the safety and feasibility of our improved approach.
Source: Neurocritical Care - January 18, 2019 Category: Neurology Source Type: research

Volatile anaesthetics versus propofol in the cardiac surgical setting of remote ischaemic preconditioning: a secondary analysis of a Cochrane Systematic Review.
CONCLUSIONS: Present data do not permit a final assessment regarding the role of volatile or intravenous anaesthetics as a possible confounding factor in RIPC trials. PMID: 29945432 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - June 28, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Propofol Attenuates Inflammatory Response in LPS-Activated Microglia by Regulating the miR-155/SOCS1 Pathway
This study explored the anti-inflammatory effects of propofol in LPS-activated BV2 microglia. Propofol potently decreased the pro-inflammatory mediators, such as nitric oxide, TNF- α, and IL-6, at both the transcriptional and translational levels. Furthermore, propofol suppressed the expression of miR-155 in LPS-activated cells. Knockdown of miR-155 attenuated the anti-inflammatory effect of propofol in cells after LPS exposure. miR-155 was also confirmed as a negative regula tor of SOCS1 expression. The inhibitory effect of propofol on LPS-induced inflammation involved the upregulation of SOCS1. Overall, these results su...
Source: Inflammation - September 5, 2017 Category: Allergy & Immunology Source Type: research

Anaesthesia practices for endovascular therapy of acute ischaemic stroke: a Nordic survey
ConclusionsThis survey indicates that the majority of Nordic anaesthesia departments who manage anaesthesia for EVT are able to provide immediate 24‐h response to an EVT request. Most of these departments have institutional guidelines for EVT anaesthesia and haemodynamic management. Conscious sedation appears to be the preferred method of anaesthetic care.
Source: Acta Anaesthesiologica Scandinavica - July 1, 2017 Category: Anesthesiology Authors: M. Rasmussen, C. Z. Simonsen, L. H. S ørensen, S. Dyrskog, D. A. Rusy, D. Sharma, N. Juul Tags: Original Article Source Type: research

Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats.
CONCLUSION: Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects. PMID: 28478273 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2017 Category: Drugs & Pharmacology Authors: Zheng Y, Bu J, Yu L, Chen J, Liu H Tags: Biomed Pharmacother Source Type: research

Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats
Conclusion Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects.
Source: Biomedicine and Pharmacotherapy - May 4, 2017 Category: Drugs & Pharmacology Source Type: research

Superselective Provocative Test with Propofol Using Motor-Evoked Potential Monitoring for Managing Cerebral Arteriovenous Malformations Fed by the Anterior Choroidal Artery
We report the case of a 57-year-old man who developed an intracerebral hematoma in the left internal temporal lobe and who had an AVM with a varix in the ambient cistern, which was primarily fed by a branch of the left anterior choroidal artery (AChA) and the posterior lateral choroidal artery, and drained into the basal vein.
Source: Journal of Stroke and Cerebrovascular Diseases - June 14, 2016 Category: Neurology Authors: Makoto Isozaki, Tetsu Satow, Toshinori Matsushige, Hisae Mori, Koji Iihara Tags: Case Studies Source Type: research

Intraoperative seizures during craniotomy under general anesthesia
An acute symptomatic seizure is a clinical seizure occurring at the time of a systemic insult or in close temporal association with a documented brain insult [1]. Seizures have been reported to occur at the time of focal brain insults including head trauma, ischemic stroke, and intracranial hemorrhage [2] but have not previously been reported as an intraoperative consequence of a neurosurgical procedure. Propofol is commonly used as an anesthetic agent [3] and a treatment for status epilepticus [4], but it has been reported to be a proconvulsant in some cases [5].
Source: Seizure: European Journal of Epilepsy - March 31, 2016 Category: Neurology Authors: John Howe, Xiaoying Lu, Zoe Thompson, Gordon W. Peterson, Travis E. Losey Tags: Short communication Source Type: research

Sevoflurane anesthesia during acute right ventricular ischemia in pigs preserves cardiac function better than propofol anesthesia.
CONCLUSIONS: Inhalation anesthesia with sevoflurane seems superior to intravenous anesthesia with propofol in acute right ventricular ischemic dysfunction. PMID: 26960337 [PubMed - as supplied by publisher]
Source: Perfusion - March 9, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Haraldsen P, Metzsch C, Lindstedt S, Algotsson L, Ingemansson R Tags: Perfusion Source Type: research

Propofol Enhances Hemoglobin-Induced Cytotoxicity in Neurons.
CONCLUSIONS: These results from our current proof-of-concept study should promote more research in vitro and in vivo to develop better anesthesia care for patients with hemorrhagic stroke. PMID: 26771264 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - January 14, 2016 Category: Anesthesiology Authors: Yuan J, Cui G, Li W, Zhang X, Wang X, Zheng H, Zhang J, Xiang S, Xie Z Tags: Anesth Analg Source Type: research

Cerebral protection during neurosurgery and stroke
This article reviews the recent evidence on perioperative neuroprotection in patients undergoing brain surgery and in patients with acute stroke. Recent findings: With varying degrees of success, numerous pharmacological and nonpharmacological therapies have been employed to provide neuroprotection for patients during the perioperative period and after acute ischemic stroke (IAS). Recent studies have failed to demonstrate neuroprotective effects of intraoperative remifentanil or propofol use, although hypertonic saline may provide better brain relaxation than mannitol during elective intracranial surgery for tumor. Magnesi...
Source: Current Opinion in Anaesthesiology - September 3, 2015 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Keith J. Ruskin Source Type: research