Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats.

CONCLUSION: Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects.
PMID: 28478273 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2017 Category: Drugs & Pharmacology Authors: Zheng Y, Bu J, Yu L, Chen J, Liu H Tags: Biomed Pharmacother Source Type: research