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Condition: Epilepsy
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Total 43 results found since Jan 2013.

Why is Clinical fMRI in a Resting State?
Conclusions Despite some perceived impediments to expanding clinical rs-fMRI use, neuroradiologists were generally enthusiastic about rs-fMRI in research and clinical applications, believing that their current workplace MRI systems are suitable for rs-fMRI acquisition. Many of the concerns associated with using rs-fMRI in clinical contexts are related to: (1) developing better methods for minimizing physiological noise effects, (2) improving methods for detecting the spatial characteristics of clinically-relevant brain processing systems in individual patients, and (3) overcoming remaining standardization, training, and r...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Application and prospects of butylphthalide for the treatment of neurological diseases.
CONCLUSIONS: The varied pharmacological mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacological effects await further study.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0. PMID: 31107716 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - May 12, 2019 Category: General Medicine Authors: Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W Tags: Chin Med J (Engl) Source Type: research

Application and prospects of butylphthalide for the treatment of neurologic diseases.
CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - June 18, 2019 Category: General Medicine Authors: Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W Tags: Chin Med J (Engl) Source Type: research

Features of a Chinese family with cerebral cavernous malformation induced by a novel CCM1 gene mutation.
CONCLUSIONS: The clinical manifestations were heterogenic within this family. We identified a novel mutation (c.1396delT) was the disease-causing mutation for this family and extended the mutational spectrum of CCMs. PMID: 24034083 [PubMed - in process]
Source: Chinese Medical Journal - September 1, 2013 Category: Journals (General) Authors: Wang X, Liu XW, Lee N, Liu QJ, Li WN, Han T, Wei KK, Qiao S, Chi ZF Tags: Chin Med J (Engl) Source Type: research

Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies.
CONCLUSIONS: Various portions of the auditory system could be involved in patients with mitochondrial diseases, including cochlea, auditory nerve, auditory pathway and cortex. Hearing loss was more associated with multisystem involvement. Genotype, mutant load of mtDNA and other unknown factors could contribute to heterogeneity of hearing impairment in mitochondrial disease. PMID: 24931247 [PubMed - in process]
Source: Chinese Medical Journal - June 1, 2014 Category: Journals (General) Authors: Liu Y, Xue J, Zhao D, Chen L, Yuan Y, Wang Z Tags: Chin Med J (Engl) Source Type: research

New-Onset Geriatric Epilepsy in China: A Single-Center Study.
Conclusions: Autoimmune encephalitis is becoming an increasing risk factor of subsequent epilepsy in older people. Older patients with new epilepsy are more likely to respond to antiepileptic drugs, and drug-resistant epilepsy is uncommon. PMID: 30539903 [PubMed - in process]
Source: Chinese Medical Journal - December 14, 2018 Category: General Medicine Authors: Chen JH, Zhou XQ, Lu Q, Jin LR, Huang Y Tags: Chin Med J (Engl) Source Type: research

Tongluojiunao, a traditional Chinese medication with neuroprotective ability: A review of the cellular, molecular and physiological mediators of TLJN’s effectiveness
Publication date: March 2019Source: Biomedicine & Pharmacotherapy, Volume 111Author(s): Bahram Bibak, Manouchehr Teymouri, Ameneh Mohammadi, Ali Haghbin, Yanshu Pan, Jamal Kasaian, Peiman AlesheikhAbstractThe pressing need to discover more effective drugs for various CNS disorders has resurrected the idea of investigating the effectiveness of traditional medicines in modern science. Tongluojiunao (TLJN) is an example of revived modern herbal preparation based on traditional Chinese medicine (TCM) with a long history of administration for various types of cerebrovascular injuries and neurodegenerative diseases. TLJN is prep...
Source: Biomedicine and Pharmacotherapy - December 28, 2018 Category: Drugs & Pharmacology Source Type: research

Tongluojiunao, a traditional Chinese medication with neuroprotective ability: A review of the cellular, molecular and physiological mediators of TLJN's effectiveness.
Abstract The pressing need to discover more effective drugs for various CNS disorders has resurrected the idea of investigating the effectiveness of traditional medicines in modern science. Tongluojiunao (TLJN) is an example of revived modern herbal preparation based on traditional Chinese medicine (TCM) with a long history of administration for various types of cerebrovascular injuries and neurodegenerative diseases. TLJN is prepared from the herbal roots of Panax notoginseng (Sanchi) and dried fruits of Gardenia jasminoides (Cape Jasmine), and so far, it has demonstrated promising results in patients with vascul...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 27, 2018 Category: Drugs & Pharmacology Authors: Bibak B, Teymouri M, Mohammadi A, Haghbin A, Pan Y, Kasaian J, Alesheikh P Tags: Biomed Pharmacother Source Type: research

Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases.
Authors: Lai HC, Chang QY, Hsieh CL Abstract In this article, we review signal transduction pathways through which acupuncture treats nervous system diseases. We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer's disease, dementia, vascular demen...
Source: Evidence-based Complementary and Alternative Medicine - August 6, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling.
Abstract Glutamate is the major excitatory neurotransmitter in the central nervous system, and its signaling is critical for excitatory synaptic transmission. The well-established glutamate system involves glutamate synthesis, presynaptic glutamate release, glutamate actions on the ionotropic glutamate receptors (NMDA, AMPA, and kainate receptors) and metabotropic glutamate receptors, and glutamate uptake by glutamate transporters. When the glutamate system becomes dysfunctional, it contributes to the pathogenesis of neurodegenerative and neuropsychiatric diseases, such as, Alzheimer's disease, Parkinson's disease...
Source: Current Neuropharmacology - October 31, 2019 Category: Drugs & Pharmacology Authors: Liu Y, Wang S, Kan J, Zhang J, Zhou L, Huang Y, Zhang Y Tags: Curr Neuropharmacol Source Type: research

Efficacy of phenobarbital in treating elderly epilepsy patients in rural northeast China: a community-based intervention trial
In the latest study, there were approximately 45.9 million individuals with active epilepsy (at least one breakthrough seizure in the past 5 years) globally and approximately 3.26 million patients with epilepsy (PWE) in China [1]. Epilepsy is the third most common neurological disorder in the elderly population after stroke and dementia [2] and is comparatively more frequent in this population than in the young population [3]. The number of patients with late-onset epilepsy (LOE; recurrent unprovoked seizures starting at 60 years or older [4]) has increased significantly, representing up to 25% of new-onset epilepsies [5].
Source: Seizure: European Journal of Epilepsy - May 11, 2021 Category: Neurology Authors: Nan Li, Jing Li, Danyang Zhao, Weihong Lin Source Type: research

A Study to Decipher the Potential Effects of Butylphthalide against Central Nervous System Diseases Based on Network Pharmacology and Molecular Docking Integration Strategy
CONCLUSIONS: Our study proposed a drug-target-disease integrated method to predict the drug repurposing potentials to associated diseases by application of NP and MD, which could be an attractive alternative to facilitate the development of CNS disease therapies. NBP may be promising and showed potentials to be repurposed for treatments for AD, epilepsy, ALS, and depression, and further investigations are warranted to be carefully designed and conducted.PMID:34035826 | PMC:PMC8116153 | DOI:10.1155/2021/6694698
Source: Molecular Medicine - May 26, 2021 Category: Molecular Biology Authors: Qinqin Zhao Bei Zheng Pinpin Feng Xiang Li Source Type: research

Molecules, Vol. 26, Pages 4700: The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches
Trabace Celastrol, the most abundant compound derived from the root of Tripterygium wilfordii, largely used in traditional Chinese medicine, has shown preclinical and clinical efficacy for a broad range of disorders, acting via numerous mechanisms, including the induction of the expression of several neuroprotective factors, the inhibition of cellular apoptosis, and the decrease of reactive oxygen species (ROS). Given the crucial implication of these pathways in the pathogenesis of Central Nervous System disorders, both in vitro and in vivo studies have focused their attention on the possible use of this compound in th...
Source: Molecules - August 3, 2021 Category: Chemistry Authors: Stefania Schiavone Maria Grazia Morgese Paolo Tucci Luigia Trabace Tags: Review Source Type: research