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Total 113302 results found since Jan 2013.

Months after hospitalization for COVID-19, MRIs reveal multiorgan damage
This study found abnormal MRI results in 20% to 25% of both controls and hospitalized patients, suggesting “a lot of these cardiac abnormalities that were seen in the COVID group must have been there beforehand.” Post–COVID-19 patients with lingering cardiac symptoms might have disorders like heartbeat irregularities that aren’t always visible with MRI, or dysfunction in other organs, he adds. Although it can offer clues to an organ’s health, MRI is an imperfect measure of how a patient is faring after infection. Researchers found no connection between abnormal liver MRIs and symptoms such as gastroin...
Source: ScienceNOW - September 22, 2023 Category: Science Source Type: news

Increasing SARS-CoV-2 seroprevalence among UK pediatric patients on dialysis and kidney transplantation between January 2020 and August 2021
ConclusionsAnti-SARS-CoV-2 seroprevalence was low in 2020 and increased in early 2021. Serological surveillance complements nucleic acid detection and antigen testing to build a greater picture of the epidemiology of COVID-19 and is therefore important to guide public health responses.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Shape Anisotropy ‐Governed High‐Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs
Magnetic particle imaging (MPI) offers high contrast, sensitivity, and signal-to-noise ratios for lung imaging, enhancing theranostic strategies in respiratory disease. Innovations in MPI tracers promise further gains, bolstering clinical applicability. This work introduces a superior nanotracer, leveraging magnetic nanoparticle shape anisotropy, elevating sensitivity and resolution beyond conventional spherical counterparts for lung MPI. AbstractCaused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) has shown extensive lung manifestations in vulnerable individuals, putt...
Source: Small - September 22, 2023 Category: Nanotechnology Authors: Saumya Nigam, Jeotikanta Mohapatra, Ashley V. Makela, Hanaan Hayat, Jessi Mercedes Rodriguez, Aixia Sun, Elizabeth Kenyon, Nathan A. Redman, Dana Spence, George Jabin, Bin Gu, Mohamed Ashry, Lorenzo F. Sempere, Arijit Mitra, Jinxing Li, Jia Tags: Research Article Source Type: research

Dietary supplements to reduce symptom severity and duration in people with SARS-CoV-2: a double-blind randomised controlled trial
Background COVID-19 has caused morbidity, hospitalisation and mortality worldwide. Despite effective vaccines, there is still a need for effective treatments, especially for people in the community. Dietary supplements have long been used to treat respiratory infections, and preliminary evidence indicates some may be effective in people with COVID-19. We sought to evaluate whether a combination of vitamin C, vitamin D3, vitamin K2 and zinc could improve overall health and decrease symptom burden in outpatients diagnosed with COVID-19. Methods Participants were randomised to receive either vitamin C (6 g), vitamin D3 (1000...
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Seely, D., Legacy, M., Conte, E., Keates, C., Psihogios, A., Ramsay, T., Fergusson, D. A., Kanji, S., Simmons, J.-G., Wilson, K. Tags: Open access, Complementary medicine, COVID-19 Source Type: research

Collective aeromedical evacuations of SARS-CoV-2-related ARDS patients in a military tactical plane: a retrospective descriptive study
After the appearance of the COVID-19 pandemic in France, MEROPE system was created to transform the military tactical ATLAS A400M aircraft into a flying intensive care unit. Collective aeromedical evacuations (aero-MEDEVAC) of patients suffering from SARS-CoV-2-related acute respiratory distress syndrome was performed from June to December 2020. A total of 22 patients were transported during seven missions. All aero-MEDEVAC was performed in safe conditions for patients and crew. No life-threatening conditions occurred during flight. Biohazard controls were applied according to French guidelines and prevented crew contamina...
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Martinez, T., Simon, K., Lely, L., Nguyen Dac, C., Lefevre, M., Aloird, P., Leschiera, J., Strehaiano, S., Nespoulous, O., Boutonnet, M., Raynaud, L. Tags: COVID-19 Personal view Source Type: research

Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research

Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Am J Public Health. 2023 Sep 21:e1-e9. doi: 10.2105/AJPH.2023.307381. Online ahead of print.ABSTRACTData System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28...
Source: Am J Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Helen Ward Christina Atchison Matthew Whitaker Bethan Davies Deborah Ashby Ara Darzi Marc Chadeau-Hyam Steven Riley Christl A Donnelly Wendy Barclay Graham S Cooke Paul Elliott Source Type: research

Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes - combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CL < sup > Pro < /sup >
RSC Med Chem. 2023 Jan 3;14(9):1667-1697. doi: 10.1039/d2md00394e. eCollection 2023 Sep 19.ABSTRACTA novel class of bioactive complexes (1-3) [MII(L)2(bpy)], where, L = 2-(4-morpholinobenzylideneamino)phenol, bpy = 2,2'-bipyridine, MII = Mn (1), Co (2) or Ni (3), were assigned to octahedral geometry based on analytical and spectral measurements. Gel electrophoresis showed that complex (2) demonstrated significant DNA cleavage activity compared to the other complexes under the action of oxidation agent (H2O2). The DNA binding constant properties measured by various techniques were in the following sequence: (2) > (3) >...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Karunganathan Sakthikumar Bienfait Kabuyaya Isamura Rui Werner Ma çedo Krause Source Type: research

Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.PMID:37733239 | DOI:10.2807/1560-7917.ES.2023.28.38.2200938
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Tom áš Kliegr Ji ří Jarkovský Helena Ji řincová Jaroslav Kucha ř Tom áš Karel David Chud án Stanislav Voj íř Michal Zav řel Ond řej Šanca Ruth Tachezy Source Type: research

Surveillance of SARS-CoV-2 infection based on self-administered swabs, Denmark, May to July 2022: evaluation of a pilot study
ConclusionParticipants successfully performed self-swabs and answered symptom questionnaires. Also, WGS analysis of samples was possible. The system can support surveillance of respiratory pathogens and also holds potential as a diagnostic tool, easing access to test for at-risk groups, while also reducing the burden on healthcare system resources.PMID:37733236 | DOI:10.2807/1560-7917.ES.2023.28.38.2200907
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Kamille Fogh Tine Graakj ær Larsen Cyril Jean-Marie Martel Frederik Trier M øller Lasse Skafte Vestergaard Ramona Trebbien Anne-Marie Vangsted Tyra Grove Krause Source Type: research

Effects of pulmonary rehabilitation in survivors of severe acute respiratory syndrome coronavirus 2. Role of vaccination
Monaldi Arch Chest Dis. 2023 Sep 18. doi: 10.4081/monaldi.2023.2738. Online ahead of print.ABSTRACTSurvivors of severe COVID-19 requiring hospital admission may suffer from short- and long-term sequelae, including disability and reduced physical performance. Vaccination and pulmonary rehabilitation (PR) are effective tools against COVID-19 effects. While the beneficial effect of each of these treatments is known, there are no data about their combined effect. In people admitted to PR hospitals after severe COVID-19 disease, we retrospectively analyzed whether PR outcome might be influenced by vaccination status. Ninety-six...
Source: Monaldi Archives for Chest Disease - September 21, 2023 Category: Respiratory Medicine Authors: Matteo Vigna Piero Ceriana Mara Santomassimo Michele Vitacca Mauro Maniscalco Nicolino Ambrosino Source Type: research

Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Am J Public Health. 2023 Sep 21:e1-e9. doi: 10.2105/AJPH.2023.307381. Online ahead of print.ABSTRACTData System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28...
Source: American Journal of Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Helen Ward Christina Atchison Matthew Whitaker Bethan Davies Deborah Ashby Ara Darzi Marc Chadeau-Hyam Steven Riley Christl A Donnelly Wendy Barclay Graham S Cooke Paul Elliott Source Type: research

Evaluation of concentration procedures, sample pre-treatment, and storage condition for the detection of SARS-CoV-2 in wastewater
Environ Sci Pollut Res Int. 2023 Sep 21. doi: 10.1007/s11356-023-29696-y. Online ahead of print.ABSTRACTCrucial information on the pandemic's spread has been gathered by monitoring the trend of SARS-CoV-2 in wastewater. This surveillance has highlighted that the initial concentration is a critical step of the analytical procedure due to the low viral titer that may be present in this matrix. This paper presents the results of the evaluation of two different wastewater concentration protocols to determine the most efficient and cost-effective. The two methods tested were the following: (a) a biphasic separation system with ...
Source: Environmental Science and Pollution Research International - September 21, 2023 Category: Environmental Health Authors: Francesca Cutrupi Michele Rossi Maria Cadonna Elisa Poznanski Serena Manara Mattia Postinghel Giulia Palumbi Marta Bellisomi Elena Nicosia Giorgia Allaria Lorenzo Dondero Carolina Veneri Pamela Mancini Giusy Bonanno Ferraro Giuseppina Rosa Elisabetta Suff Source Type: research

Recent Advances in Metagenomic Approaches, Applications, and Challenge
Curr Microbiol. 2023 Sep 21;80(11):347. doi: 10.1007/s00284-023-03451-5.ABSTRACTAdvances in metagenomics analysis with the advent of next-generation sequencing have extended our knowledge of microbial communities as compared to conventional techniques providing advanced approach to identify novel and uncultivable microorganisms based on their genetic information derived from a particular environment. Shotgun metagenomics involves investigating the DNA of the entire community without the requirement of PCR amplification. It provides access to study all genes present in the sample. On the other hand, amplicon sequencing targ...
Source: Current Microbiology - September 21, 2023 Category: Microbiology Authors: Niguse K Lema Mesfin T Gemeda Adugna A Woldesemayat Source Type: research

Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Arch Med Sci. 2021 Apr 23;19(5):1327-1359. doi: 10.5114/aoms/135703. eCollection 2023.ABSTRACTCOVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system. COVID-19 (coronavirus) and other enveloped viruses including severe acute respiratory syndrome (SARS-CoV-1 of 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) and hepatitis B and C (HBV and HCV) can be inactivated by AA, γ-linolenic acid (GLA, dihomo-GLA (DGLA), eicosapentaenoic ...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Undurti N Das Source Type: research