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Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

Cancer is associated with intraoperative and postprocedural complications and disorders
Conclusion The present study indicates that cancer increases the risk of IPCs and may reduce the clinical benefits of surgery.
Source: Journal of Cancer Research and Clinical Oncology - December 9, 2015 Category: Cancer & Oncology Source Type: research

The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database.
Abstract Obstructive sleep apnoea (OSA) is a highly prevalent condition but studies exploring the burden of OSA-associated comorbidities have been limited by small sample sizes with underrepresentation of women.We queried the Truven Health MarketScan Research Databases 2003-2012, which is a collection of health insurance claims for working adults and retirees with employer-sponsored health insurance. Adults with a diagnostic code for OSA with at least 12 months of follow-up from the index date of OSA diagnosis were compared to a matched random sample. Comorbidities were assessed using International Classificatio...
Source: Respiratory Care - January 21, 2016 Category: Respiratory Medicine Authors: Mokhlesi B, Ham SA, Gozal D Tags: Eur Respir J Source Type: research

The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database
Obstructive sleep apnoea (OSA) is a highly prevalent condition but studies exploring the burden of OSA-associated comorbidities have been limited by small sample sizes with underrepresentation of women. We queried the Truven Health MarketScan Research Databases 2003–2012, which is a collection of health insurance claims for working adults and retirees with employer-sponsored health insurance. Adults with a diagnostic code for OSA with at least 12 months of follow-up from the index date of OSA diagnosis were compared to a matched random sample. Comorbidities were assessed using International Classification of Dis...
Source: European Respiratory Journal - March 31, 2016 Category: Respiratory Medicine Authors: Mokhlesi, B., Ham, S. A., Gozal, D. Tags: Sleep medicine Original Articles: Sleep Source Type: research

Mental Illness Is On The Rise But Access To Care Keeps Dwindling
More Americans than ever before are experiencing mental health problems, yet access to treatment for those issues is becoming more difficult to receive, a new study has found. A new analysis of data from the Centers for Disease Control and Prevention’s National Health Interview Survey shows that serious psychological distress, or SPD, defined as severe sadness and depressive symptoms that interfere with a person’s physical wellbeing, is on the rise just as resources for mental health treatment are declining.  Researchers from NYU’s Langone Medical Center analyzed almost a decade’s worth of data...
Source: Healthy Living - The Huffington Post - April 17, 2017 Category: Consumer Health News Source Type: news

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Increased Risk of Lymphoid Malignancy in Patients with Herpes Zoster: A Longitudinal Follow-up Study Using a National Cohort Study
Conclusion: Our study demonstrates that herpes zoster infection increases the risk of subsequent lymphoid malignancies irrespective of age and gender in the Korean population.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Lee, Y. K., Kim, M., Kim, H. J., Lim, H., Choi, H. G. Tags: 902. Health Services Research-Malignant Diseases: Quality Of Life Studies Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Association between depression risk and polycystic ovarian syndrome in young women: a retrospective nationwide population-based cohort study (1998 –2013)
This study was supported in part by the Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW108-TDU-B-212-133  004), China Medical University Hospital, Academia Sinica Stroke Biosignature Project (BM10701010021), MOST Clinical Trial Consortium for Stroke (MOST 107-2321-B-039 -004-), Tseng-Lien Lin Foundation, Taichung, Taiwan and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. No competing interest existe d.TRIAL REGISTRATION NUMBERN/A.
Source: Human Reproduction - August 13, 2019 Category: Reproduction Medicine Source Type: research

Major Adverse Cardiovascular Events in Antidepressant Users Within Patients With Ischemic Heart Diseases: A Nationwide Cohort Study
Conclusions Compared with antidepressant nonusers, use of antidepressants was not associated with occurrence of MACEs in patients with depression and IHD. Although the overall effect of antidepressants on the risk of MACE was neutral, careful monitoring of MACE development is recommended in high-dose SSRI users.
Source: Journal of Clinical Psychopharmacology - September 1, 2020 Category: Psychiatry Tags: Original Contributions Source Type: research

MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.
Authors: Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM, MarkVCID Consortium Abstract The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple ...
Source: The Journal of Alzheimers Association - January 24, 2021 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Valuing health states of people with type 2 diabetes: Analyses of the nationwide representative linked databases
ConclusionsMajor vascular complications, connective tissue disease, and depression are associated with considerably worse HRQoL. These health utility estimates can facilitate health economic evaluations to determine cost ‐effective strategies for diabetes management.
Source: Journal of Diabetes Investigation - February 4, 2021 Category: Endocrinology Authors: Shihchen Kuo, Chun ‐Ting Yang, Hsuan‐Ying Chen, Huang‐Tz Ou Tags: ORIGINAL ARTICLE Source Type: research

Valuing health states of people with type  2 diabetes: Analyses of the nationwide representative linked databases
ConclusionsMajor vascular complications, connective tissue disease and depression are associated with considerably worse health ‐related quality of life. These health utility estimates can facilitate health economic evaluations to determine cost‐effective strategies for diabetes management.
Source: Journal of Diabetes Investigation - March 3, 2021 Category: Endocrinology Authors: Shihchen Kuo, Chun ‐Ting Yang, Hsuan‐Ying Chen, Huang‐Tz Ou Tags: Original Article Source Type: research