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Total 407 results found since Jan 2013.

Lithium intoxication presenting as altered consciousness and arrhythmia with cardiogenic shock: A case report
Rationale: Lithium has been used to treat bipolar disorder. Lithium has a narrow therapeutic index, with a therapeutic level between 0.6 and 1.5 mEq/L. The possible complications of lithium overdose include altered mental status, hand tremor, muscle weakness, nausea, vomiting, diarrhea, seizure, syncope, and arrhythmia. Lithium intoxication can be fatal and is difficult to diagnose in patients without a history of lithium intake. The occurrence of serious cardiac arrhythmias is rare in lithium intoxication. Patient concerns: An 81-year-old man was brought to the emergency department because of consciousness disturba...
Source: Medicine - November 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3 β inhibition in intracerebral hemorrhage rats.
In this study, Male Sprague-Dawley rats, subjected to intrastriatal blood infusion, were treated with lithium chloride and underwent neurobehavioral test for equivalent injury severity and neurological functional deficits, Morris water maze test for cognitive impairment, high performance liquid chromatography analysis for excitotoxic index determination, immunohistochemistry analysis for neuronal apoptosis, and Western blot analysis for glycogen synthase kinase-3β activity. Our results showed lithium chloride inhibited glycogen synthase kinase-3β activation, which on one hand, suppressed downstream CRMP-2/NR2B, thus dimi...
Source: European Journal of Pharmacology - October 15, 2018 Category: Drugs & Pharmacology Authors: Liu Z, Li R, Jiang C, Zhao S, Li W, Tang X Tags: Eur J Pharmacol Source Type: research

Mood stabilisers and risk of stroke in bipolar disorder.
CONCLUSIONS: Use of carbamazepine and valproic acid, but not lithium and lamotrigine, is associated with increased risk of stroke in patients with bipolar disorder.Declaration of interestNone. PMID: 30295208 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - October 10, 2018 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

New Insights into the Use of Cardiac Magnetic Resonance Imaging to Guide Decision Making in Atrial Fibrillation Management
Publication date: Available online 12 July 2018Source: Canadian Journal of CardiologyAuthor(s): Tarek Zghaib, Saman NazarianAbstractRecent advances in cardiac magnetic resonance (CMR) imaging acquisition techniques have enabled the visualization of thin atrial myocardium with high temporal and spatial resolution and have the potential to shift atrial fibrillation (AF) management paradigms. Late gadolinium-enhancement (LGE)-CMR can noninvasively identify atrial arrhythmogenic scar substrates and has been shown to spatially correlate with low-voltage areas. Immediately after ablation, a combination of native T1-weighted, LGE...
Source: Canadian Journal of Cardiology - October 6, 2018 Category: Cardiology Source Type: research

Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity.
Conclusion: Heat stimulation by M-RF treatment induced upregulation of UCP1 and FGF21 expression in serum and/or WATs, which was correlated with reduced total body and WAT weight gain in DIO mice. PMID: 30275865 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - October 4, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Midterm outcomes of mini-invasive surgical and hybrid ablation of atrial fibrillation.
CONCLUSIONS: . Combination of mini-invasive surgical and endocardial treatment (two-stage hybrid procedure) is a safe and effective method for the treatment of isolated (lone) AF. This procedure provided good midterm outcomes. PMID: 30214077 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 16, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Chapter Seventeen - Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature
Publication date: 2018Source: International Review of Neurobiology, Volume 139Author(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors (placebo respo...
Source: International Review of Neurobiology - August 24, 2018 Category: Neuroscience Source Type: research

rTMS Effects in Patients with Co-Morbid Somatic Pain and Depressive Mood Disorders
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation treatment that involves the induction of electrical currents in a targeted region of the brain with the ability to impact various functional processes (Chervyakov  et al., 2015). rTMS has shown to provide clinical improvement among a variety of neurological and psychiatric disorders and has been FDA-approved for treatment resistant depression (TRD). rTMS continues to undergo trials for other treatment indications including post-traumatic stress disorder (PT SD), generalized anxiety disorder (GAD), bipolar depression, schizophrenia, stro...
Source: Journal of Affective Disorders - August 18, 2018 Category: Neurology Authors: Angela L. Phillips, Robert L. Burr, David L. Dunner Tags: Research paper Source Type: research

Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature
Publication date: Available online 2 August 2018Source: International Review of NeurobiologyAuthor(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors ...
Source: International Review of Neurobiology - August 3, 2018 Category: Neuroscience Source Type: research

Évaluation de la prévalence de l’hypertension artérielle de l’adulte en milieu du travail à Kinshasa, République Démocratique du Congo
ConclusionL’HTA est une pathologie fréquente en milieu de travail et l’obésité en est le principal facteur de risque modifiable. L’élaboration et la mise en place d’un programme de prévention et de prise en charge dans le cadre de la santé au travail s’avère indispensable.AbstractBackgroundArterial hypertension (AHT) is a major cardiovascular risk factor in the occurrence of stroke, heart failure, renal insufficiency and coronary heart disease, which are the leading causes of death worldwide. Insufficient data on high blood pressure in the workplace in the Democratic Republic of Congo, led us to carry out ...
Source: Science and Sports - July 10, 2018 Category: Sports Medicine Source Type: research

Metallomics Applied to the  Study of Neurodegenerative and Mental Diseases.
Metallomics Applied to the Study of Neurodegenerative and Mental Diseases. Adv Exp Med Biol. 2018;1055:21-37 Authors: Sussulini A, Hauser-Davis RA Abstract Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiolo...
Source: Advances in Experimental Medicine and Biology - June 11, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Évaluation de la prévalence de l’hypertension artérielle de l’adulte en milieu du travail à Kinshasa, République Démocratique du Congo
Conclusion L’HTA est une pathologie fréquente en milieu de travail et l’obésité en est le principal facteur de risque modifiable. L’élaboration et la mise en place d’un programme de prévention et de prise en charge dans le cadre de la santé au travail s’avère indispensable. Background Arterial hypertension (AHT) is a major cardiovascular risk factor in the occurrence of stroke, heart failure, renal insufficiency and coronary heart disease, which are the leading causes of death worldwide. Insufficient data on high blood pressure in the workplace in the Democratic Republic of Congo, led us to carry out an an...
Source: Science and Sports - May 11, 2018 Category: Sports Medicine Source Type: research

Atrial Fibrillation and Injected Aripiprazole: A Case Report
Conclusion In summary, although it is not possible to exclude confounding factors, the timing and dose-dependent effect of aripiprazole administration in our patient suggests an association between an initial intramuscular injection of long-acting aripiprazole and new onset of AF. This observation calls for clinical vigilance, not only in patients with additional risk factors for stroke but also in younger patients who might have predisposing factors for arrhythmias. References CPS (Canadian Pharmacists Association). Available at: http://www.e-therapeutics.ca. Accessed January 1, 2017. Polcwiartek C, Sneider B, Graff C,...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adverse effects aripiprazole atrial fibrillation schizoaffective disorder Source Type: research

TRPM2: a candidate therapeutic target for treating neurological diseases.
Abstract Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca2+)-permeable non-selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced TRPM2 activation provokes aberrant intracellular Ca2+ accumulation and cell death in a variety of cell types, including neurons. Aberrant TRPM2 function has been implicated in several neurological disorders including ischemia/stroke, Alzheimer's disease, neuropathic pain, Parkinson's disease and bipolar disorder. In addition to research identifying a role for TRPM2 in disease, progress has been made in the identification of physiolog...
Source: Acta Pharmacologica Sinica - April 19, 2018 Category: Drugs & Pharmacology Authors: Belrose JC, Jackson MF Tags: Acta Pharmacol Sin Source Type: research