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Fast Heartburn Relief Without Deadly Drugs
Since gastroesophageal reflux disease (GERD) was first identified in the early 1930s, the number of people experiencing heartburn has increased substantially. In fact, one study shows that in just 10 years, the number of people experiencing:1 Any GERD symptoms increased by 30% Symptoms at least once a week increased by 47% Severe GERD increased by 24% While these numbers are concerning, I’ll admit they’re not surprising considering the typical American diet. Our nutrition-less, grain-based diet of carbohydrates and starches has wrecked our health and made our bodies behave in ways nature never intended. This has led ...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Heart Health Natural Cures Nutrition Source Type: news

Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
Conclusions: Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.PMID:37510727 | PMC:PMC10380859 | DOI:10.3390/jcm12144612
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Magdalena Szychli ńska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski El żbieta Bandurska-Stankiewicz Source Type: research

Molecules, Vol. 28, Pages 126: In Vitro Evaluation of & alpha;-amylase and & alpha;-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from Pterocarpus erinaceus Poir
Molecules, Vol. 28, Pages 126: In Vitro Evaluation of α-amylase and α-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from Pterocarpus erinaceus Poir Molecules doi: 10.3390/molecules28010126 Authors: Romeo Toko Feunaing Alfred Ngenge Tamfu Abel Joel Yaya Gbaweng Larissa Mekontso Magnibou Fidele Ntchapda Celine Henoumont Sophie Laurent Emmanuel Talla Rodica Mihaela Dinica Diabetes mellitus is a metabolic disorder which is one of the leading causes of mortality and morbidities in elderly humans. Chronic diabetes can lead to kidney failure, blindness, limb a...
Source: Molecules - December 23, 2022 Category: Chemistry Authors: Romeo Toko Feunaing Alfred Ngenge Tamfu Abel Joel Yaya Gbaweng Larissa Mekontso Magnibou Fidele Ntchapda Celine Henoumont Sophie Laurent Emmanuel Talla Rodica Mihaela Dinica Tags: Article Source Type: research

Type 2 Diabetes Mellitus (T2DM) and Carbohydrate Metabolism in Relation to T2DM from Endocrinology, Neurophysiology, Molecular Biology, and Biochemistry Perspectives
Evid Based Complement Alternat Med. 2022 Aug 9;2022:1708769. doi: 10.1155/2022/1708769. eCollection 2022.ABSTRACTType 2 diabetes mellitus (T2DM) is a severe disease caused by metabolic disorders, particularly carbohydrate metabolism disorders. The disease is a fatal global trouble characterised by high prevalence rates, causing death, blindness, kidney failure, myocardial infarction, amputation of lower limps, and stroke. Biochemical metabolic pathways like glycolysis, gluconeogenesis, glycogenesis, and glycogenolysis are critical pathways that regulate blood glucose levels with the glucokinase (GK) enzyme playing a centra...
Source: Evidence-based Complementary and Alternative Medicine - August 19, 2022 Category: Complementary Medicine Authors: Hilla Mills Ronald Acquah Nova Tang Luke Cheung Susanne Klenk Ronald Glassen Magali Pirson Alain Albert Duong Trinh Hoang Thang Nguyen Van Source Type: research

Association of carbohydrate and saturated fat intake with cardiovascular disease and mortality in Australian women
Conclusions In middle-aged Australian women, moderate carbohydrate intake (41.0%–44.3% of TEI) was associated with the lowest risk of CVD, without an effect on total mortality. Increasing saturated fat intake was not associated with CVD or mortality and instead correlated with lower rates of diabetes, hypertension and obesity.
Source: Heart - May 25, 2022 Category: Cardiology Authors: Gribbin, S., Enticott, J., Hodge, A. M., Moran, L., Thong, E., Joham, A., Zaman, S. Tags: Cardiac risk factors and prevention Source Type: research

CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 4, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

High Dietary Glycemic Load is Associated with Poor Functional Outcome in Patients with Acute Cerebral Infarction.
CONCLUSIONS: Increased dietary GL and carbohydrate intake were associated with a poor short-term functional outcome after an acute ischemic stroke. PMID: 29629525 [PubMed]
Source: Journal of Clinical Neurology - April 10, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Low glycaemic index diets for the prevention of cardiovascular disease.
CONCLUSIONS: There is currently no evidence available regarding the effect of low GI diets on cardiovascular disease events. Moreover, there is currently no convincing evidence that low GI diets have a clear beneficial effect on blood lipids or blood pressure parameters. PMID: 28759107 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 31, 2017 Category: General Medicine Authors: Clar C, Al-Khudairy L, Loveman E, Kelly SA, Hartley L, Flowers N, Germanò R, Frost G, Rees K Tags: Cochrane Database Syst Rev Source Type: research

Worsened arterial stiffness in high-risk cardiovascular patients with high habitual carbohydrate intake: a cross-sectional vascular function study
Conclusions: High-carbohydrate diet is associated with increased arterial stiffness in patients with established cardiovascular disease or risk equivalent.
Source: BMC Cardiovascular Disorders - February 21, 2014 Category: Cardiology Authors: Hiu-Ting ChanYap-Hang ChanKai YiuSheung-Wai LiSidney TamChu-Pak LauHung-Fat Tse Source Type: research