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Total 430 results found since Jan 2013.

Rethinking Retirement in the 21st Century
Conclusion In the 21st century, many seniors are not retiring from something. Instead, retirement is an opportunity for reinventing, reimagining and reconnecting to one's self, family, friends and community. Robert Browning once wrote, "Grow old along with me! The best is yet to be." By investing in your physical, mental and financial health today, you can help ensure that your best years are just ahead. Rear Admiral Susan Blumenthal, M.D., M.P.A. (ret.) is the Public Health Editor of The Huffington Post. She is a Senior Fellow in Health Policy at New America and a Clinical Professor at Tufts and Georgetown University Sc...
Source: Healthy Living - The Huffington Post - May 1, 2015 Category: Consumer Health News Source Type: news

Effect of white matter lesions on manual dexterity in healthy middle-aged persons
Conclusions: Greater WML volumes in different brain regions are associated with higher pegboard scores (worse performance) independent of age, sex, race, education, and total or regional volumes. This suggests that small vessel cerebrovascular disease may be present in healthy individuals in a preclinical state with measurable impact on complex integrative functions in individuals with excess risk of clinical vascular disease.
Source: Neurology - May 11, 2015 Category: Neurology Authors: Nyquist, P. A., Yanek, L. R., Bilgel, M., Cuzzocreo, J. L., Becker, L. C., Chevalier-Davis, K., Yousem, D., Prince, J., Kral, B. G., Vaidya, D., Becker, D. M. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Vascular dementia, Prevalence studies, Risk factors in epidemiology ARTICLE Source Type: research

Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience.
Abstract Reported rates of dementia differ by race, although most studies have not focused on carefully measured outcomes, confounding by education or other demographic factors, nor have they studied other outcomes other than dementia. In this review we will discuss the experience in the Atherosclerosis Risk in Communities (ARIC) study evaluating racial disparities relating to stroke, subclinical brain infarction, leukoaraiosis, as well as cognitive change and dementia. ARIC is a biracial cohort of 15,792 participants from four U.S. communities, initially recruited in 1987-1989, and seen at a total of 5 in-person ...
Source: Current Alzheimer Research - August 8, 2015 Category: Neurology Authors: Gottesman RF, Fornage M, Knopman DS, Mosley TH Tags: Curr Alzheimer Res Source Type: research

Frailty, dependency and mortality predictors in a cohort of Cuban older adults, 2003-2011.
CONCLUSIONS: Given the challenge for developing countries presented by demographic and epidemiologic transition; the high prevalence in older adults of frailty syndrome, dependency and chronic non-communicable diseases; and the association of all these with higher mortality, attention should be targeted to older adults as a risk group. This should include greater social protection, age-appropriate health services, and modification and control of cardiovascular risk factors. PMID: 24487672 [PubMed - indexed for MEDLINE]
Source: MEDICC Review - November 21, 2015 Category: Global & Universal Tags: MEDICC Rev Source Type: research

Effects of Brain Derived Neurotrophic Factor on White Matter Integrity in Middle-Aged Adults: A Voxel-Based Diffusion Tensor Imaging Study (S39.006)
Conclusions: In our community-based, stroke-free middle-aged sample, elevated BDNF has a subtle, positive effect on WM microstructural integrity in specific tracts whose integrity was also found to be associated with preserved executive function. These data can expand our understanding of the structural pathways in the brain implicated in BDNF mediated preservation of cognitive reserve and protection from vascular brain injury.Disclosure: Dr. Maillard has nothing to disclose. Dr. Satizabal has nothing to disclose. Dr. Beiser has nothing to disclose. Dr. Himali has nothing to disclose. Dr. Chen has nothing to disclose. Dr. ...
Source: Neurology - February 7, 2016 Category: Neurology Authors: Maillard, P., Satizabal, C., Beiser, A., Himali, J., Chen, T., Vasan, R., Seshadri, S., DeCarli, C. Tags: Aging and Dementia: Pathology and Imaging Source Type: research

10-year trajectories of depressive symptoms and risk of dementia: a population-based study
We examined a cohort of participants who were free from dementia, but had data for depressive symptoms from at least one examination round in 1993–95, 1997–99, or 2002–04. We assessed depressive symptoms with the validated Dutch version of the Center for Epidemiology Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale-Depression. We used these data to identify 11-year trajectories of depressive symptoms by latent class trajectory modelling. We screened participants for dementia at each examination round and followed up participants for 10 years for incident dementia by latent trajectory from the th...
Source: The Lancet Psychiatry - May 12, 2016 Category: Psychiatry Source Type: research

The Diagnostic Utility of the NINDS-CSN Neuropsychological Battery in Memory Clinics
Conclusion: The NINDS-CSN neuropsychological battery can be applied in memory clinics and effectively discriminate between cognitively intact individuals and those with cognitive impairments of varying severity. Furthermore, level of education should be taken into consideration when choosing protocols with different lengths for cognitive assessment.Dement Geriatr Cogn Disord Extra 2016;6:276-282
Source: Dementia and Geriatric Cognitive Disorders Extra - July 14, 2016 Category: Geriatrics Source Type: research

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE- ε4.
Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep;30(3):210-5 Authors: Nation DA, Preis SR, Beiser A, Bangen KJ, Delano-Wood L, Lamar M, Libon DJ, Seshadri S, Wolf PA, Au R Abstract We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent...
Source: Alzheimer Disease and Associated Disorders - August 26, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4
We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent baseline neuropsychological and magnetic resonance imaging (subset, n=454) evaluations with 5- to 7-year follow-up. Regression analyses investigated associations between baseline pulse pressure (systolic−diastolic pressure) and cognition, total cerebral volume and temporal horn ventricular volume (...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Investigating the Prevalence of Dementia and Its Associated Risk Factors in a Chinese Nursing Home.
CONCLUSIONS: Our study found a high prevalence of dementia in a Chinese nursing home, and a high prevalence of patients with severe dementia. Risk factors for dementia included a low educational level, an advanced age, and a history of stroke. Appropriate interventions need to be applied to this population. PMID: 27868396 [PubMed - as supplied by publisher]
Source: Journal of Clinical Neurology - November 23, 2016 Category: Neurology Tags: J Clin Neurol Source Type: research

Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241 Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03, Bos...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

'Tooth loss link to increased risk of dementia'
Conclusion This study adds to the evidence that good oral health is linked to good overall health, including a reduction in the chances of developing dementia in later life. But the research doesn't prove that regular tooth brushing will prevent dementia. We don't know what causes dementia. From research so far, it looks as if there are a number of interlinked causes. Brain health and ageing are likely to be affected by factors including diet, exercise, smoking, alcohol use, blood pressure and genetics. While living a healthy lifestyle may certainly reduce the chances of dementia, there are no guarantees. This study ha...
Source: NHS News Feed - March 9, 2017 Category: Consumer Health News Tags: Mental health Neurology Older people Source Type: news

Prognostic factors for mortality in patients with bullous pemphigoid: a meta-analysis
This study indicated that BP patients with older age, circulating antibodies, dementia, and stroke are at greater risk of mortality. Clinicians should be aware of this association and utilize this information in patient education and treatment process.
Source: Archives of Dermatological Research - March 18, 2017 Category: Dermatology Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Higher Aortic Stiffness is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults.
Conclusions -Greater aortic stiffening relates to lower regional CBF and higher CVR in cognitively normal older adults, especially among individuals with increased genetic predisposition for Alzheimer's disease. Central arterial stiffening may contribute to reductions in regional CBF despite preserved cerebrovascular reserve capacity. PMID: 30018169 [PubMed - as supplied by publisher]
Source: Circulation - July 17, 2018 Category: Cardiology Authors: Jefferson AL, Cambronero FE, Liu D, Moore EE, Neal JE, Terry JG, Nair S, Pechman KR, Rane S, Davis LT, Gifford KA, Hohman TJ, Bell SP, Wang TJ, Beckman JA, Carr JJ Tags: Circulation Source Type: research