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Condition: Autoimmune Disease

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Total 2213 results found since Jan 2013.

Local Immunoglobulin Production in Nasal Tissues: A Key to Pathogenesis in CRSwNP and AERD.
CONCLUSION: More studies are needed to determine the role of B cells and antibodies in driving disease in these patients. However, targeting the processes that drive local B cell activation and antibody production may provide new therapeutic approaches and could help to reduce chronic inflammation. PMID: 33065294 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - October 13, 2020 Category: Allergy & Immunology Authors: Buchheit KM, Hulse KE Tags: Ann Allergy Asthma Immunol Source Type: research

A Case of Linear IgA Bullous Dermatosis Induced by Aspirin Therapy.
Abstract Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease that may be triggered by some diseases and medications. For the latter one, non-steroidal anti-inflammatory drugs (NSAIDs) have been identified as one of the potential causative agents to develop LABD. Here, a rare case of drug-induced LABD is introduced. A 13-month-old Iranian boy presented with a history of generalized blisters, displaying the classic "string of pearls" sign who was eventually diagnosed as a case of LABD. In his admission, he was diagnosed whit Mucocutaneous lymph node syndrome and treated with aspirin.  Some ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Nabavi M, Rezaeifar A, Sadeghinia A, Arshi S, Bahrami S, Bemanian MH, Fallahpour M, Shokri S, Vakilazad Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Increased Level of Caspase-1 in the Serum of Relapsing-remitting Multiple Sclerosis (RRMS) Patients.
In this study, we used an ELISA assay to measure serum and cellular caspase-1 and serum levels of IL-18 and IL-1β in RRMS patients in the relapse phase (n=23) and healthy age-and gender-matched controls (n=19). We observed that the caspase-1 level was significantly increased in the serum of MS patients compared to the healthy controls (p=0.03). Although caspase-1 concentration in the lysate of peripheral blood mononuclear cells (PBMCs) was higher than serum among patients and controls (p<0.001), no significant difference was found in cellular levels of caspase-1 between the two groups. There was no significant differen...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Beheshti M, Salehi Z, Abolfazli R, Shirzad H, Izad M Tags: Iran J Allergy Asthma Immunol Source Type: research

Gene Co-expression Network Analysis for Identifying Modules and Functionally Enriched Pathways in Vitiligo Disease: A Systems Biology Study.
Abstract Vitiligo is the most common cause of skin, hair, and oral depigmentation which is known as an autoimmune disorder. Genetic and environmental factors have important roles in the progression of the disease. Dysregulation of gene expression, like microRNAs (miRNA), may serve as major relevant factors. Several biological processes are involved in vitiligo disease and developing a comprehensive approach helps us to better understand the molecular mechanisms of disease. In this research, we describe how a weighted gene co-expression network analysis as a systems biology approach assists to define the primary ge...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Derakhshani A, Mollaei H, Parsamanesh N, Fereidouni M, Miri-Moghaddam E, Nasseri S, Luo Y, Safarpour H, Baradaran B Tags: Iran J Allergy Asthma Immunol Source Type: research

Intravenous Immunoglobulin Therapy in Myocarditis.
Abstract Myocarditis is an inflammatory disease of the myocardium with lymphocyte infiltration and myocyte necrosis leading to a wide range of clinical presentations including heart failure, arrhythmia, and cardiogenic shock. Infectious and noninfectious agents may trigger the disease. The fact that immunosuppressive drugs are useful in several kinds of autoimmune myocarditis is proof of the autoimmune mechanisms involved in the development of myocarditis. Pathogenic mechanisms in myocardial inflammation are including inflammasome activation followed by myocyte destruction, myocarditis, and pericarditis. Intraveno...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Mansourabadi AH, Gol Mohammad Pour Afrakoti L, Shahi A, Shabanian R, Amirzargar A Tags: Iran J Allergy Asthma Immunol Source Type: research

Total IgE as a Marker for Chronic Spontaneous Urticaria.
CONCLUSION: The results of our review suggest that total IgE is a valuable marker for CSU, and we recommend its assessment in the routine diagnostic workup of CSU patients. PMID: 33474856 [PubMed]
Source: Allergy, Asthma and Immunology Research - January 23, 2021 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Clinical variables of severe Chronic Spontaneous Urticaria from total IgE standpoint: a retrospective study.
Conclusions. Baseline total IgE show a high high prognostic value for omalizumab response with a threshold level of 18 IU/ml. Males seem more responsive to omalizumab. Most patients show a mixed clinical picture where signs of atopic status co-exist with signs of an autoimmune disease. PMID: 33555151 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - February 9, 2021 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Immunobiologicals and ocular surface disease
Purpose of review Immunobiologicals have surfaced to become a new cornerstone of treatment for a wide spectrum of inflammatory disorders with an immune basis. The targets have ranged from autoimmune conditions to transplantation, and now more into atopic inflammatory disorders with primary targets of asthma and atopic dermatitis. Recent findings The clinical information garnered from these studies have provided an initial snapshot on the potential adverse effects of the immunobiologicals on the ocular surface as well as providing a potential opening of their use in the treatment of various chronic ocular surface...
Source: Current Opinion in Allergy and Clinical Immunology - September 15, 2022 Category: Allergy & Immunology Tags: EYE ALLERGY: Edited by Leonard Bielory and Abraham Solomon Source Type: research

Allergy in patients with anti-N-methyl-d-aspartate receptor encephalitis.
CONCLUSIONS: Patients with anti-NMDAR encephalitis show higher allergic rate than those with virus encephalitis. Patients with allergy show higher CSF antibody titers and greater illness severity. However, the final outcome of anti-NMDAR encephalitis was not influenced. PMID: 29306850 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - January 4, 2018 Category: Neurology Authors: Jiang XY, Zhang L, Jiang X, Abdulaziz ATA, Wang YH, Li JM, Zhou D Tags: Epilepsy Behav Source Type: research

Allergy in patients with anti-N-methyl-d-aspartate receptor encephalitis
Conclusions Patients with anti-NMDAR encephalitis show higher allergic rate than those with virus encephalitis. Patients with allergy show higher CSF antibody titers and greater illness severity. However, the final outcome of anti-NMDAR encephalitis was not influenced.
Source: Epilepsy and Behavior - January 5, 2018 Category: Neurology Source Type: research

High Frequency of Concomitant Food Allergy Development and Autoantibody Formation in Children Who Have Undergone Liver Transplantation
Conclusions. In contrast to respiratory allergy, food allergy and autoantibody formation occurred together in the same children who underwent liver transplantation at a frequency higher than would be expected by chance. This may reflect an underlying immune dysregulation that impairs immune tolerance to both food allergens and autoantigens.
Source: Transplantation - October 29, 2019 Category: Transplant Surgery Tags: Original Clinical Science–Liver Source Type: research

News Beyond Our Pages
Although the increasing number of persons with allergic diseases can be largely attributed to environmental components, understanding the genetic heritability underlying these conditions is vital to understanding these diseases. Hinds et al (Nat Genet 2013;45:907-11) selected 3 common self-reported allergy phenotypes (pollen, dust mite, and cat allergies), used generalized estimating equations to model shared and allergy-specific effects, and performed genome-wide association meta-analyses of both. For shared effects across allergies, the authors identified 16 genome-wide significant loci, including 8 previously associated...
Source: Journal of Allergy and Clinical Immunology - October 30, 2013 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson Tags: News beyond our pages Source Type: research

Analysis of the impact of allergy and atopy on new onset of uveitis
ConclusionsOur results argue against a substantial influence of allergies and atopy on the onset of uveitis.
Source: Acta Ophthalmologica - September 28, 2016 Category: Opthalmology Authors: Rafael S. Grajewski, Niusha Barahmand Pour, Katja Burian, Albert Caramoy, Bernd Kirchhof, Claus Cursiefen, Ludwig M. Heindl Tags: Original Article Source Type: research

The Epigenetics of Food Allergy.
Authors: Chang C, Wu H, Lu Q Abstract Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental exposures contribute to the development of atopy. In this chapter, we discuss the interplay between these three key elements, reveal how epigenetic modifications may mediate genetic su...
Source: Advances in Experimental Medicine and Biology - May 25, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Maternal autoimmune disease and risk of hospitalization for autoimmune disease, allergy, and cancer in offspring
CONCLUSIONS: Maternal autoimmune disease is associated with an increased risk of autoimmune disease and allergy hospitalization in offspring, but the relationship appears to be confounded by genetic and environmental factors. Prenatal exposure to immunologic or pharmacologic products is not likely a direct cause of immune-mediated disease in children.PMID:35212046 | DOI:10.1111/pai.13728
Source: Cancer Control - February 25, 2022 Category: Cancer & Oncology Authors: Xiaotian Zhao Philippe B égin Harb Kang M élanie Henderson Antoine Lewin Ga Eun Lee Jessica Healy-Profit ós Nathalie Auger Source Type: research