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Localized carbon dioxide laser treatment of a recalcitrant oral ulceration in pemphigus vulgaris
ConclusionsAdjunctive procedures that can facilitate a decrease in the cumulative dosages of corticosteroids and immunosuppressants have great value in the management of PV. CO2 laser vaporization is a safe procedure with minimal morbidity and no long-term side effects and should be considered as an adjunctive treatment option for management of recalcitrant lesions in patients with oral PV.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

PARP-14 Promotes Survival of Mammalian α but Not β Pancreatic Cells Following Cytokine Treatment
Conclusion This study must be seen as a first piece of a puzzle where PARP-14, JNKs and PJ-34 play key roles in the pancreatic microenvironment and provide starting points from which to explore further. Author Contributions VS-P conceived the project and designed the experiments together with MP and CD. MR and FD performed molecular experiments as RT-PCR and western analysis. CS and MS performed confocal analysis. FD, NM, and VB performed cytofluorimetric analysis. FD and MC were in charge of cell culture and treatment. FD performed computational and statistical data analysis, together with AT-S. VS-P and FD wrote the p...
Source: Frontiers in Endocrinology - May 2, 2019 Category: Endocrinology Source Type: research

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria
This study was conducted in the rural village of Kalifabougou, Mali where intense P. falciparum transmission occurs from June to December each year. Isolation of Tonsil B Cells Tonsils were mechanically disrupted in complete RPMI (RPMI 1640 with L-glutamine supplemented with 10% heat-inactivated FBS, 1 mM sodium pyruvate, 1% MEM nonessential amino acids, 50 μM 2-mercaptoethanol, 100 U/ml penicillin, 100 μg/ml streptomycin, and 25 mM HEPES, pH 7.2–7.5 [all from GIBCO, Invitrogen]) and passed through a 70-μm cell strainer to make a single cell suspension. B cells were then negatively selecte...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

The Impact of Hyperosmolality on Activation and Differentiation of B Lymphoid Cells
This study was carried out in accordance with the German Law on Care and Use of Laboratory Animals. Euthanasia and organ preparation were approved by the local authorities (Landratsamt Erlangen-Hoechstadt, Erlangen, Germany). Author Contributions LC designed the study, planned, and performed experiments, analyzed and interpreted data and wrote the manuscript. SP designed the study, interpreted data, and edited the manuscript. JT initiated the study and supported the work. H-MJ made key suggestions, assisted in the design of experiments, interpreted data and critically reviewed the manuscript. WS designed the study, plann...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Focused Ultrasound Improves NK-92MI Cells Infiltration Into Tumors
Conclusion In conclusion, we demonstrated that the combination of FUS and microbubbles could increase the NK-92MI cells’ infiltration into tumors in this study. The combination of FUS and NK-92MI had a much better therapeutic effect when compared with the PBS group, but no superior therapeutic effect when compared with the NK-92MI group. In total, FUS and microbubbles can improve NK cells’ infiltration into tumors, but future work is still needed to improve NK-92MI cells’ delivery efficiency for solid tumor treatment. Ethics Statement This study was carried out in accordance with the recommendations...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation
Discussions Autoantibodies targeting Dsg1 and Dsg3 are pathogenic and cause blister formation by inducing structural desmosomal changes in the skin of PV patients (42). However, the mechanisms underlying disease development and the factors enhancing its manifestation have not yet been fully elucidated. Secondary factors promoting severity of the disease include non-Dsg antibodies (43) as well as genetic alterations such as recently reported ST18 SNPs (29–31) and may also entail keratinocyte-derived cytokine release. Here, we investigate the effect of ST18 overexpression and cytokine secretion on PV-IgG mediated l...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
This study was carried out in accordance with the recommendations of The London School of Hygiene & Tropical Medicine (LSHTM) Research Ethics Committee (Ref. 6123) and the National Research Ethics Service (NRES) London-Bloomsbury Research Ethics Committee (REC ref. 11/10/1760, IRAS ID: 77765), with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the LSHTM Research Ethics Committee and the NRES London-Bloomsbury Research Ethics Committee. Author Contributions JC, HD, LN, EL, and ER devised the study ...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions
In conclusion, our findings identify ALCAM as a novel therapeutic target for preventing corneal allograft rejection in high-risk patient populations. Moreover, given the documented contribution of ALCAM to (lymph)angiogenesis, DC migration, and T cell activation, ALCAM blockade might represent a therapeutic strategy for treating other immune-mediated inflammatory conditions, such as solid organ transplant rejection, allergy or autoimmune diseases. Experimental Procedures Cloning, Expression, and Purification of I/F8-Fc and KSF-Fc For cloning of I/F8-Fc and KSF-Fc the respective scFv sequence was amplified from previousl...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice
Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Frosted branch angiitis in an octogenarian with infective endocarditis
Conclusion: We hypothesize that our patient developed FBA as an immunogenic response to Streptococcus viridans and Streptococcus oralis infection. Previous associations between streptococci and FBA have been made. Notably, beta-hemolytic streptococcal antigens are known to cross-react with retinal antigens. However, the implicated pathogens in our patient were alpha-hemolytic. Alpha-hemolytic streptococcal endophthalmitis has been linked to frosted branch response before, but it has never been associated with FBA through an immunogenic pathway. Therefore, it is important to note that idiopathic FBA can be associated with i...
Source: Retinal Cases and Brief Reports - January 1, 2015 Category: Opthalmology Tags: Case Report Source Type: research

Retrospective cohort study of 4591 Straumann implants in private practice setting, with up to 10‐year follow‐up. Part 1: multivariate survival analysis
ConclusionHigh long‐term survival rates were observed for a large cohort of Straumann implants. Tissue‐ and Bone‐Level implants had higher survival rates than Tapered Effect implants, and although short implants faired well in the mandibular posterior sites, they faired less well in the maxillary posterior sites. The study represents private practice insight into large‐scale, long‐term implant results.
Source: Clinical Oral Implants Research - August 18, 2014 Category: Dentistry Authors: David French, Hannu Larjava, Ronen Ofec Tags: Original Article Source Type: research

Autoimmune hemolytic anemia occurred in burn patient: A case report
Anemia is a common complication in severe burn patients associated with considerable morbidity and worse outcome. Reasons for anemia in burn patients include the thermal damage to erythrocytes at the time of injury, the subsequent impairment of bone marrow erythropoiesis due to systemic inflammation or sepsis, the external blood loss from granulation wounds or due to surgery, and the poor nutritional status, etc. . Autoimmune hemolytic anemia (AIHA) is an immune disorder caused by antibodies directed against unmodified autologous red cells. It may be primary (idiopathic) or secondary to other diseases such as lymphoprolife...
Source: Burns : Journal of the International Society for Burn Injuries - September 16, 2013 Category: Cosmetic Surgery Authors: Yanjun Wu, Jiaping Zhang, Jun Wu Tags: Case Reports - E-only Source Type: research