Focused Ultrasound Improves NK-92MI Cells Infiltration Into Tumors

Conclusion In conclusion, we demonstrated that the combination of FUS and microbubbles could increase the NK-92MI cells’ infiltration into tumors in this study. The combination of FUS and NK-92MI had a much better therapeutic effect when compared with the PBS group, but no superior therapeutic effect when compared with the NK-92MI group. In total, FUS and microbubbles can improve NK cells’ infiltration into tumors, but future work is still needed to improve NK-92MI cells’ delivery efficiency for solid tumor treatment. Ethics Statement This study was carried out in accordance with the recommendations of Institutional Animal Care and Use Committee (IACUC) of Guangzhou Medical University. Author Contributions CY, FY, and ZC designed the study. CY and MD performed the experimental work. CY were dealt the manuscript and data analysis, and drafted the manuscript. FY and ZC revised the manuscript. Funding This work was supported by the National Natural Science Foundation of China (No. 81671707), the Natural Science Foundation of Guangdong Province (Nos. 2016A030311054 and 2018A030313678), Research Projects of Guangzhou Science Technology and Innovation Commission (No. 201607010201), and Research Fund for Lin He’s Academician Workstation of New Medicine and Clinical Translation. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research