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Condition: Diabetes Type 2

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Total 3594 results found since Jan 2013.

The Effect of Metformin on Vitamin B12 Deficiency and Stroke
CONCLUSIONS: T2DM is a significant risk factor to the development of ischemic stroke. We found an association between metformin use and vitamin B12 deficiency and an association between vitamin B12 deficiency and stroke risk in patients with T2DM. Diabetic patients who are taking metformin should monitor their vitamin B12 level.PMID:36841981
Source: The Israel Medical Association Journal - February 26, 2023 Category: General Medicine Authors: Nizar Horrany Wadie Abu Dahoud Yara Moallem Taleb Hajouj Merna Zreik Arnon Blum Source Type: research

CD4+CD28- lymphocytes and ischaemic stroke. Part I: CD4+CD28- lymphocytes and common carotid artery intima-media thickness.
Conclusions: The significant proportion of CD4+CD28- lymphocytes in patients with ischaemic stroke points to the in-volvement of the cells in the pathogenesis of stroke. The CD4+CD28- lymphocytes are not involved in the pathomechanism of common carotid arteries IMT thickening in this group of patients. PMID: 23821416 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - July 6, 2013 Category: Neurology Authors: Drechsler H, Masztalewicz M, Safranow K, Nowacki P Tags: Neurol Neurochir Pol Source Type: research

GLP-1R activation for the treatment of stroke: Updating and future perspectives
Abstract Stroke is the leading cause of adult disability in Westernized societies with increased incidence along ageing and it represents a major health and economical threat. Inactive lifestyle, smoking, hypertension, atherosclerosis, obesity and diabetes all dramatically increase the risk of stroke. While preventive strategies based on lifestyle changes and risk factor management can delay or decrease the likelihood of having a stroke, post stroke pharmacological strategies aimed at minimizing stroke-induced brain damage are highly needed. Unfortunately, several candidate drugs that have shown significant precl...
Source: Reviews in Endocrine and Metabolic Disorders - September 1, 2014 Category: Endocrinology Source Type: research

Sitagliptin After Ischemic Stroke in Type 2 Diabetic Patients: A Nationwide Cohort Study
Abstract: The cerebrovascular safety and efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes mellitus (T2DM) with ischemic stroke remains uncertain. The aim of this study was to assess the efficacy and safety of sitagliptin in patients with T2DM with recent ischemic stroke. We analyzed data from the Taiwan National Health Insurance Research Database between March 1, 2009, and December 31, 2011. Ischemic stroke patients were identified from individuals with T2DM. Patients who received sitagliptin were compared with those who did not to evaluate the cardiovascular safety and efficacy...
Source: Medicine - July 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Effects of Pioglitazone for Secondary Stroke Prevention in Patients with Impaired Glucose Tolerance and Newly Diagnosed Diabetes: The J-SPIRIT Study.
CONCLUSIONS: While this study was too underpowered to determine the effect of pioglitazone, the result failed to show beneficial effects in patients of ischemic stroke or TIA with impaired glucose tolerance and newly diagnosed diabetes. PMID: 26269002 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 15, 2015 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Long-Term Risk of Stroke in Patients With Type 1 and Type 2 Diabetes Following Coronary Artery Bypass Grafting Cardiovascular Surgery
Conclusions The long-term risk for stroke after coronary artery bypass grafting was increased in patients with type 1 and type 2 diabetes, compared to patients with no diabetes.
Source: JAHA:Journal of the American Heart Association - November 9, 2015 Category: Cardiology Authors: Nystrom, T., Holzmann, M. J., Sartipy, U. Tags: Cardiovascular Surgery Source Type: research

Long ‐term excess risk of stroke in people with Type 2 diabetes in Sweden according to blood pressure level: a population‐based case–control study
ConclusionsPeople with Type 2 diabetes and blood pressure < 130/80 mmHg had a risk of stroke similar to that of the general population.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 24, 2016 Category: Endocrinology Authors: C. H. Stahl, M. Lind, A. ‐M. Svensson, M. Kosiborod, S. Gudbjörnsdottir, A. Pivodic, M. Clements, A. Rosengren Tags: Original Article Source Type: research

Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China.
In conclusion, our findings indicated that Chinese women with T2DM are less susceptible to CHD and stroke than men. Further, MS increases the risk of both these events, highlighting the need for comprehensive metabolic control in T2DM. PMID: 28042294 [PubMed]
Source: International Journal of Endocrinology - January 4, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Effect of Chinese herbal medicine on stroke patients with type 2 diabetes
Conclusion The use of CHM as adjunctive therapy may improve the overall survival (OS) of stroke patients with T2D. The list of the comprehensive herbal medicines that they used might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments in stroke patients with T2D. Graphical abstract
Source: Journal of Ethnopharmacology - February 19, 2017 Category: Drugs & Pharmacology Source Type: research

Incident ischaemic stroke and Type 2 diabetes: trends in incidence and case fatality in Scotland 2004 –2013
ConclusionsIschaemic stroke incidence declined no faster in people with a diagnosis of Type 2 diabetes than in people without diabetes. Increasing prevalence of Type 2 diabetes among stroke patients may mean that declines in case fatality over time will be less marked in the future.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - October 17, 2017 Category: Endocrinology Authors: S. H. Read, D. A. McAllister, H. M. Colhoun, B. Farran, C. Fischbacher, J. J. Kerssens, G. P. Leese, R. S. Lindsay, R. J. McCrimmon, S. McGurnaghan, S. Philip, N. Sattar, S. H. Wild, Tags: Research Article Source Type: research

Associations between nonalcoholic fatty liver disease and ischemic stroke.
Authors: Alkagiet S, Papagiannis A, Tziomalos K Abstract Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease and affects a considerable proportion of the general population. NAFLD is independently associated with increased risk for cardiovascular events, particularly coronary heart disease. Importantly, even though NAFLD is more prevalent in patients with major cardiovascular risk factors (e.g., type 2 diabetes mellitus, obesity and hypertension), the association between NAFLD and cardiovascular disease appears to be independent of these risk factors. However, NAFLD also appears to incre...
Source: World Journal of Hepatology - August 12, 2018 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Risk of ischemic stroke after third, fourth, and sixth cranial nerve palsies in type 2 diabetes
ConclusionsPhysicians should pay more attention to manageable risk factors of ischemic stroke when diabetic patients suffer from ocular motor CN palsies.
Source: Journal of Diabetes - November 15, 2018 Category: Endocrinology Authors: Sang Jun Park, Hee Kyung Yang, Seong Jun Byun, Kyu Hyung Park, Jeong ‐Min Hwang Tags: ORIGINAL ARTICLE Source Type: research

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.
Abstract Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Here, twenty-three big...
Source: European Journal of Medicinal Chemistry - May 17, 2020 Category: Chemistry Authors: Xin G, Ming Y, Ji C, Wei Z, Li S, Morris-Natschke SL, Zhang X, Yu K, Li Y, Zhang B, Zhang J, Xing Z, He Y, Chen Z, Yang X, Niu H, Lee KH, Huang W Tags: Eur J Med Chem Source Type: research

Macrophage –NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes
In this study, we found that the cardiac dysfunction induced by ischemic stroke is more severe in a mouse model of type 2 diabetes. Meanwhile, M1-polarized macrophage in filtration and NLRP3 inflammasome activation increased in the cardiac ventricle after diabetic stroke. Importantly, the NLRP3 inflammasome inhibitor CY-09 restored cardiac function, indicating that the M1-polarized macrophage–NLRP3 inflammasome activation is a pathway underlying the brain–heart interaction after diabetic stroke.
Source: Neuroscience Bulletin - July 17, 2020 Category: Neuroscience Source Type: research

Concurrency of Early-Age Exposure to Chinese Famine and Diabetes Increases Recurrence of Ischemic Stroke
Conclusions: Concurrency of early-age famine exposure and diabetes mellitus was associated with a higher risk of stroke recurrence within 12 months, and adherence to evidence-based KPI did not reduce the risk significantly.
Source: Frontiers in Neurology - January 20, 2021 Category: Neurology Source Type: research