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Condition: Asthma

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Total 404 results found since Jan 2013.

The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways.
In conclusion, the FFAR1 promoted airway smooth muscle cell proliferation and p70S6K phosphorylation through MEK/ERK and PI3K/Akt signaling pathways. PMID: 29097424 [PubMed - as supplied by publisher]
Source: Am J Physiol Lung Ce... - November 2, 2017 Category: Respiratory Medicine Authors: Matoba A, Matsuyama N, Shibata S, Masaki E, Emala CW, Mizuta K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Transforming growth factor- β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1.
This article is protected by copyright. All rights reserved. PMID: 29071730 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - October 25, 2017 Category: Physiology Authors: Shaifta Y, MacKay CE, Irechukwu N, O'Brien KA, Wright DB, Ward JPT, Knock GA Tags: J Physiol Source Type: research

Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma
Conclusion: Our results indicate the potential role of SIRT1 in regulating inflammation by modulation of IL-6 expression in an Akt-dependent manner during allergic asthma.Cell Physiol Biochem 2017;43:1950 –1960
Source: Cellular Physiology and Biochemistry - October 20, 2017 Category: Cytology Source Type: research

IL-1 β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma.
IL-1β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma. Immunol Lett. 2017 Oct 12;192:20-26 Authors: Wu S, Li H, Yu L, Wang N, Li X, Chen W Abstract The manifest and important feature in respiratory diseases, including asthma and COPD (chronic obstructive pulmonary disease), is the increased numbers and hypersecretion of goblet cells and overexpression of mucins, especially Muc5ac. Many proinflammatory cytokines play important roles in goblet cell metaplasia and overproduction of Muc5ac. However, the effect of IL-1β on Muc5ac expression in asthma remains unknown. Here, we detected ...
Source: Immunology Letters - October 12, 2017 Category: Allergy & Immunology Authors: Wu S, Li H, Yu L, Wang N, Li X, Chen W Tags: Immunol Lett Source Type: research

TGF- β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3.
In this study, we set out to investigate the direct effects of TGF-β1 on human airway smooth muscle (HASM) cell shortening and hyperresponsiveness. The dynamics of AHR and single-cell excitation-contraction (E-C) coupling were measured in human precision-cut lung slices (hPCLS) and in isolated HASM cells using supravital microscopy and magnetic twisting cytometry (MTC), respectively. In hPCLS, overnight treatment with TGF-β1 significantly augmented basal and carbachol-induced bronchoconstriction. In isolated HASM cells, TGF-β1 increased basal and methacholine-induced cytoskeletal stiffness in a dose- and time-dependent ...
Source: American Journal of Respiratory Cell and Molecular Biology - October 6, 2017 Category: Molecular Biology Authors: Ojiaku CA, Cao G, Zhu W, Yoo EJ, Shumyatcher M, Himes BE, An SS, Panettieri RA Tags: Am J Respir Cell Mol Biol Source Type: research

Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation
Publication date: April 2018 Source:Redox Biology, Volume 14 Author(s): John D. Dickinson, Jenea M. Sweeter, Kristi J. Warren, Iman M. Ahmad, Xavier De Deken, Matthew C. Zimmerman, Steven L. Brody The airway epithelium is a broad interface with the environment, mandating well-orchestrated responses to properly modulate inflammation. Classically, autophagy is a homeostatic pathway triggered in response to external cellular stresses, and is elevated in chronic airway diseases. Recent findings highlight the additional role of autophagy in vesicle trafficking and protein secretion, implicating autophagy pathways in complex ce...
Source: Redox Biology - October 3, 2017 Category: Biology Source Type: research

A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA
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Source: Gene Therapy - September 21, 2017 Category: Genetics & Stem Cells Authors: M Choi J Gu M Lee T Rhim Source Type: research

G α12 Facilitates Carbachol‐Induced Shortening in Human Airway Smooth Muscle By Modulating Phosphoinositide 3‐Kinase‐Mediated Activation In A RhoA‐Dependent Manner
CONCLUSION AND IMPLICATIONSGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - September 18, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research

A new combination therapy for asthma using dual function dexamethsone-conjugated polyethylenimine and vitamin D binding protein siRNA
Gene Therapy, Published online: 28 August 2017; doi:10.1038/gt.2017.83
Source: Gene Therapy - August 28, 2017 Category: Genetics & Stem Cells Authors: M Choi J Gu M Lee T Rhim Source Type: research

Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells.
CONCLUSIONS: The results from this study confirm the central importance of 15LO1 and its primary product 15-HETE-PE to epithelial cell remodeling in HAECs. PMID: 28723225 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - July 19, 2017 Category: Respiratory Medicine Authors: Zhao J, Minami Y, Etling E, Coleman JM, Lauder SN, Tyrrell V, Aldrovandi M, O'Donnell V, Claesson HE, Kagan V, Wenzel S Tags: Am J Respir Cell Mol Biol Source Type: research

Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma
In this study, we hypothesized that Follistatin-like 1 (FSTL1) promotes EMT and airway remodeling by intensifying autophagy. With the use of transmission electron microscopy (TEM), double-membrane autophagosomes were detected in the airways of patients and mice. More autophagosomes were in patients with asthma and OVA-challenged mice compared with healthy controls. The expression of FSTL1 and beclin-1 was upregulated in the airways of patients with asthma and OVA-challenged mice, accompanied by airway EMT and remodeling. In OVA-challenged Fstl1+/– mice, the degree of airway remodeling and autophagy was decreased comp...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2017 Category: Respiratory Medicine Authors: Liu, T., Liu, Y., Miller, M., Cao, L., Zhao, J., Wu, J., Wang, J., Liu, L., Li, S., Zou, M., Xu, J., Broide, D. H., Dong, L. Tags: RESEARCH ARTICLE Source Type: research

Anti-inflammatory effect of anti-tnf- α cationic phosphorous dendrimers nanocomplexes administered intranasally in a murine acute lung injury model.
ANTI-INFLAMMATORY EFFECT OF ANTI-TNF-α CATIONIC PHOSPHOROUS DENDRIMERS NANOCOMPLEXES ADMINISTERED INTRANASALLY IN A MURINE ACUTE LUNG INJURY MODEL. Biomacromolecules. 2017 Jun 22;: Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Abstract Inflammation is an essential component of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD) or acute lung injury. Our purpose was to design efficient carriers for lung delivery of small interfering RNA (siRNA) targeting tumor necrosis factor (TNF-α) in an...
Source: Biomacromolecules - June 22, 2017 Category: Biochemistry Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Tags: Biomacromolecules Source Type: research

Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBP β activation in human lung fibroblasts
In this study, we investigated the roles that ribosomal S-6 kinase 1 (RSK1)/CCAAT/enhancer-binding protein β (C/EBPβ)-dependent ADAM 17 expression plays in hypoxia-induced CTGF expression in human lung fibroblasts. We observed that hypoxia caused increases in ADAM 17 expression and ADAM 17-luciferase activity in WI-38 cells. Hypoxia-induced CTGF-luciferase activity and CTGF expression were reduced in cells transfected with small interfering (si)RNA of ADAM 17 in WI-38 cells. Moreover, hypoxia-induced ADAM 17 expression was reduced by RSK1 siRNA and C/EBPβ siRNA. Hypoxia caused time-dependent increases in RSK1 phosphoryl...
Source: Molecular Immunology - June 21, 2017 Category: Allergy & Immunology Source Type: research

Autophagy Plays a Role in FSTL1-induced EMT and Airway Remodeling in Asthma.
In this study, we hypothesized that Follistatin-like 1(FSTL1) promotes EMT and airway remodeling by intensifying autophagy. Using transmission electron microscopy (TEM), double membrane autophagosomes were detected in the airways of patients and mice. More autophagosomes were in asthmatic patients and OVA-challenged mice compared to healthy control. The expression of FSTL1 and Beclin1 were upregulated in the airways of asthmatic patients and OVA-challenged mice, accompany with airway EMT and remodeling. In OVA-challenged Fstl1+/- mice, the degree of airway remodeling and autophagy were decreased compared to control mice. T...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 4, 2017 Category: Cytology Authors: Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

p300 and C/EBP β-regulated IKKβ expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells
In this study, we aimed to investigate the roles of p300 and C/EBPβ-reliant IKKβ expression in thrombin-induced IL-8/CXCL8 expression. Thrombin-induced increases in IL-8/CXCL8-luciferase activity and IL-8/CXCL8 release were inhibited by p300 small interfering (siRNA). Thrombin-caused histone H3 acetylation was attenuated by p300 siRNA. Stimulation of cells with thrombin for 12h resulted in increases in IKKβ expression and phosphorylation in human lung epithelial cells. However, thrombin did not affect p65 expression. Moreover, 12h of thrombin stimulation produced increases in IKKβ expression and phosphorylation, and I...
Source: Pharmacological Research - April 26, 2017 Category: Drugs & Pharmacology Source Type: research