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Condition: Asthma

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Total 404 results found since Jan 2013.

Cold Stimuli Facilitate Inflammatory Responses Through Transient Receptor Potential Melastatin 8 (TRPM8) in Primary Airway Epithelial Cells of Asthmatic Mice
AbstractBronchial asthma is a chronic inflammatory airway disease that can be aggravated by cold air. However, its mechanism remains largely unknown. As a thermo-sensing cation channel, transient receptor potential melastatin 8 (TRPM8) can be activated by cold stimuli (8 –22 °C) and cooling agents. Whereas TRPM8 activation leads to enhanced expression of inflammatory cytokines and mucus hypersecretion in human bronchial epithelial cell lines, no previous study has examined its role in regulating the cold-induced inflammatory responses and its mechanism in asthma tic airway epithelium. Airway epithelial cells were isola...
Source: Inflammation - April 9, 2018 Category: Allergy & Immunology Source Type: research

TRPC3 overexpression and intervention in airway smooth muscle of ovalbumin-induced hyperresponsiveness and remodeling.
Abstract Transient receptor potential canonical channel 3 (TRPC3) proteins function as non-voltage-gated Ca2+ -permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression and airway hyperresponsiveness and remodeling in ovalbumin-induced asthmatic Kunming mice. Mice were sensitized and challenged by ovalbumin to establish asthmatic model. Hematoxylin-eosin staining, hydroxyproline assay and isometric tracheal ring force measurement were used to evaluate airway remodeling and hyperresponsiveness in asthmatic m...
Source: Cell Biology International - April 6, 2018 Category: Cytology Authors: Xu BM, Zhang JH, Wang JL, Xiao JH Tags: Cell Biol Int Source Type: research

Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.
Abstract Adipokines, a group of proteins including leptin, visfatin, resistin, and adiponectin, are produced by adipocytes. Among adipokines, resistin is implicated in insulin resistance and inflammatory response modulation. Mucus hypersecretion has been greatly linked to airway diseases, such as asthma, chronic obstructive pulmonary disease, and rhinosinusitis. Increasing evidence has indicated that adipokines, such as leptin and visfatin, play important regulatory roles in various biological processes involved in mucus secretion. However, the effects of resistin on mucin expression in human airway epithelial cel...
Source: Biochemical and Biophysical Research communications - March 28, 2018 Category: Biochemistry Authors: Kwak S, Kim YD, Na HG, Bae CH, Song SY, Choi YS Tags: Biochem Biophys Res Commun Source Type: research

MID1 –PP2A complex functions as new insights in human lung adenocarcinoma
ConclusionsWe demonstrated that the MID1 –PP2A complex plays an important role in lung adenocarcinoma, influencing cell cycle progression, proliferation and apoptosis. Our findings showed a novel molecular mechanism of lung tumorigenesis that may provide new insights for anti-tumor therapies.
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research

High-fat-diet induces airway hyperresponsiveness partly through activating CD38 signaling pathway.
This study aimed to detect the effect of CD38 signaling pathway on the AHR of overweight/obese mice. The HFD-fed mice exhibited a significantly higher baseline airway resistance (Rn), and the increasing rates of Rn responded to increasing doses of methacholine compared with the LFD-fed mice. High-fat-diet increased CD38 expressions both in lung tissues and primary cultured ASMCs. Besides, preincubation with TNF-α led to a higher expression of CD38 protein and increased intracellular calcium in ASMC of the HFD-fed mice. Furthermore, CD38 gene knockdown through transfection of CD38 siRNA decreased the concentration of intra...
Source: International Immunopharmacology - February 1, 2018 Category: Allergy & Immunology Authors: Chong L, Zhang W, Yu G, Zhang H, Zhu L, Li H, Shao Y, Li C Tags: Int Immunopharmacol Source Type: research

HMGB1 ‐induced asthmatic airway inflammation through GRP75‐mediated enhancement of ER‐mitochondrial Ca2+ transfer and ROS increased
Abstract Imbalanced T‐helper (TH)1/Th2 response contributes significantly to asthma pathogenesis. Our study indicated that HMGB1 play an important role in the release of Th2‐associated cytokines of asthma. However, the specific mechanism about HMGB1‐induced imbalanced TH1/Th2 response is not known. In vivo, an OVA‐induced asthma mouse model was set up and mice treated with anti‐HMGB1 IgG. The mice treated with the anti‐HMGB1 IgG ameliorated airway hyper‐reactivity, disruption of Th1/Th2 balance and the upregulation of GRP75 induced by OVA. In vitro, the exposure of normal human bronchial epithelial cells to H...
Source: Journal of Cellular Biochemistry - January 25, 2018 Category: Biochemistry Authors: Yanhua Lv, Yanli Li, Dandan Zhang, Anbing Zhang, Weihong Guo, Shunfang Zhu Tags: RESEARCH ARTICLE Source Type: research

PINX1 and TERT Are Required for TNF- α-Induced Airway Smooth Muscle Chemokine Gene Expression.
In this study, we sought to address two key questions: whether telomerase is involved in inflammation in ASM cells, and whether components of the shelterin complex are also required for an inflammatory response in ASM cells. Telomerase inhibitors and telomerase small interfering RNA (siRNA) reduced TNF-α-induced chemokine expression in ASM cells. Telomerase siRNA and inhibitors reduced NF-κB activity. An siRNA screen of shelterin components identified a requirement for PIN2/TERF1 interacting-telomerase inhibitor 1 (PINX1) in chemokine gene expression. High-level PINX1 overexpression reduced NF-κB reporter activity, but ...
Source: Journal of Immunology - January 5, 2018 Category: Allergy & Immunology Authors: Deacon K, Knox AJ Tags: J Immunol Source Type: research

HMGB1 ‐induced asthmatic airway inflammation through GRP75‐mediated enhancement of ER–Mitochondrial Ca2+ transfer and ROS increased
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - January 2, 2018 Category: Biochemistry Authors: Lv Yanhua, Li Yanli, Zhang Dandan, Zhang Anbing, Guo Weihong, Zhu Shunfang Tags: Article Source Type: research

PDK1/RSK1-dependent C/EBP{beta} activation is involved in thrombin-induced expression of orosomucoid 1-like 3 (ORMDL3) and IL-8/CXCL8 in human lung epithelial cells
In this study, we investigated that the role of phosphoinositide-dependent kinase 1 (PDK1), ribosomal S6 kinase 1 (RSK1), and CCAAT/enhancer-binding protein β (C/EBPβ) in thrombin-induced expression of ORMDL3 and IL-8/CXCL8 in human lung epithelial cells (A549). We found that treatment of cells with thrombin caused ORMDL3 mRNA and protein expression. Thrombin-induced IL-8/CXCL8-luciferase activity or IL-8/CXCL8 release was inhibited by ORMDL3 siRNA, BX-912 (a PDK1 inhibitor), and PDK1 siRNA. Moreover, thrombin-stimulated ORMDL3 expression was attenuated by BX-912, PDK1 siRNA, RSK1 siRNA, and C/EBPβ siRNA. Th...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Chen, B.-C., Huang, M.-F. Tags: Airway Pharmacology and Treatment Source Type: research

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome.
Abstract Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase rele...
Source: International Journal of Molecular Medicine - December 5, 2017 Category: Molecular Biology Authors: Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW, Hsu YL Tags: Int J Mol Med Source Type: research

Interleukin-22 attenuates double-stranded RNA-induced upregulation of PD-L1 in airway epithelial cells via a STAT3-dependent mechanism.
Abstract Double-stranded RNA derived from viruses induces host immune responses. PD-L1, also known as B7-H1, is an immune-checkpoint molecule associated with the escape of viruses from host immune systems, which plays a role in the persistence of viral infection, resulting in exacerbations of underlying diseases such as asthma and chronic obstructive pulmonary disease. Interleukin (IL)-22 is produced from various immune cells and has protective properties on mucosal tissue. The binding of IL-22 to IL-22 receptor induces STAT3 activation. We investigated the effect of IL-22 on the expression in airway epithelial ce...
Source: Biochemical and Biophysical Research communications - November 30, 2017 Category: Biochemistry Authors: Seki N, Kan-O K, Matsumoto K, Fukuyama S, Hamano S, Tonai K, Ota K, Inoue H, Nakanishi Y Tags: Biochem Biophys Res Commun Source Type: research

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma.
CONCLUSIONS: These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma. PMID: 29178675 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
CONCLUSION: KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma, and may be a potential target for asthma treatment. PMID: 29156524 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 15, 2017 Category: Drugs & Pharmacology Authors: Geng G, Du Y, Dai J, Tian D, Xia Y, Fu Z Tags: Biomed Pharmacother Source Type: research

G α12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
Conclusions and ImplicationsGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - November 12, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research

Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma.
Authors: Chen H, Xu X, Cheng S, Xu Y, Xuefei Q, Cao Y, Xie J, Wang CY, Xu Y, Xiong W Abstract Asthma is a chronic T helper type 2 (Th2) cell-mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post-transcriptional level; their role in regulating allergic inflammatio...
Source: Experimental and Therapeutic Medicine - November 7, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research