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Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy
ConclusionsThe change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.
Source: General Thoracic and Cardiovascular Surgery - June 21, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Cardio-embolic stroke: Lessons from a single centre in Sub-Saharan Africa.
CONCLUSION: CES accounted for 1/4 of ischemic stroke with a high risk of early death and long-term recurrence. Atrial fibrillation was the leading cause of CES. The association of VKA and anti-platelet agent should be avoided to reduce early death during acute stroke. PMID: 31155304 [PubMed - as supplied by publisher]
Source: Revue Neurologique - June 4, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Is resynchronization therapy really efficient in laminopathy?
ConclusionCardiac resynchronization therapy seems to be less efficient in LMNA patients compared to usual implanted patients with other type of advanced cardiomyopathy. An impaired right ventricular stroke function seems to be the only predictive factor leading to poor response to CRT.
Source: Archives of Cardiovascular Diseases Supplements - March 22, 2019 Category: Cardiology Source Type: research

Echocardiographic profile of Congolese hypertensive patients.
CONCLUSIONS: Echocardiographic profile of the Congolese hypertensive is quite various, left ventricular hypertrophy is the most predominant abnormality. Efficient management on the hypertension will lead to reduce its morbidity and mortality. PMID: 30290912 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - October 2, 2018 Category: Cardiology Authors: Ikama MS, Makani J, Nsitou BM, Mongo-Ngamami SF, Ellenga-Mbolla BF, Ondze-Kafata LI, Gombet TR, Kimbally-Kaky SG Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Timing of Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy.
CONCLUSIONS: Adding MRA to a standard medical regimen for NIDCM resulted in beneficial LV remodeling. The maximal beneficial remodeling was achieved with 12-16 months of MRA therapy. These results have implications for the timing of other advanced therapies, such as placing internal cardioverter-defibrillators. PMID: 30286821 [PubMed - in process]
Source: The American Journal of the Medical Sciences - September 1, 2018 Category: General Medicine Authors: Bradham WS, Bell SP, Huang S, Harrell FE, Adkisson DW, Lawson MA, Sawyer DB, Ooi H, Kronenberg MW Tags: Am J Med Sci Source Type: research

The heart in m.3243A > G carriers.
CONCLUSIONS: Cardiac involvement in m.3243A>G carriers has been only rarely systematically studied, which is perhaps why the incidence of cardiac diseases in MELAS is lower than would be expected. Myocardial abnormalities are much more frequent than arrhythmias or conduction defects. All symptomatic and asymptomatic m.3243A>G carriers should be systematically investigated for cardiac disease. PMID: 30128910 [PubMed - as supplied by publisher]
Source: Herz - August 23, 2018 Category: Cardiology Tags: Herz Source Type: research

The contribution of systematic implementation of cardiovascular explorations for the detection of cardiac sources of embolism in patients with stroke: About 230  patients.
CONCLUSION: Cardiovascular explorations remain indispensable in the workup of all ischemic strokes even if their therapeutic effect is modest. The lacunar infarct out first at 34% followed by 32% of cardio embolic causes and atheroma of the neck vessels in approximately 16%. PMID: 29753425 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - May 9, 2018 Category: Cardiology Authors: Hadi A, Bendriss L, Khatouri A Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Is Rivaroxaban a Safe Choice for Apical Thrombus in Atrial Fibrillation Patients? A Case Report
Left ventricular thrombi are mostly seen in the akinetic segments of left ventricle and warfarin is the golden standard treatment. In our case, a 67-year-old male patient with ischemic dilated cardiomyopathy and atrial fibrillation was under warfarin treatment, but due to fluctuations in international normalized ratio, warfarin was discontinued and changed to rivaroxaban (20  mg once a day). He had a fixed thrombus measuring 1.80 × 1.12 cm2 in the left ventricle under warfarin treatment before rivaroxaban use.
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2018 Category: Neurology Authors: Fatih Aydin, Ozge Turgay Yildirim, Ayse Huseyinoglu Aydin, Evrin Dagtekin, Ercan Aksit Tags: Case Studies Source Type: research

Atherosclerosis and cardiovascular involvement in celiac disease: the role of autoimmunity and inflammation.
CONCLUSIONS: On the basis of the reported association among CD, AS and CV diseases, we suggest to perform a more detailed CV risk assessment in all CD patients than what is currently being achieved in clinical practice, in order to scan and treat modifiable CV risk factors in these patients. In particular, we suggest to resort to instrumental techniques to detect AS in the subclinical stage, in order to prevent AS development and CV diseases in CD patients. PMID: 29243787 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Cardioembolic stroke and cardiomyopathy: Rhythm is the key
Cardiomyopathy (CM) predisposes patients to cardioembolism. Stroke and peripheral embolization occur at an annual incidence rate of 0.8% in hypertrophic cardiomyopathy (HCM) [1]. Embolic events have an incidence rate ranging from 1.5 to 3.5 per 100 patient-years in dilated cardiomyopathy (DCM) [2]. However, few studies have described the clinical profile of ischemic stroke associated with CM.
Source: Journal of the Neurological Sciences - July 24, 2017 Category: Neurology Authors: Li Chung Hin, Ma Sin Kwan Tammy, Chang Richard Shek-Kwan Tags: Letter to the Editor Source Type: research

Key Questions Relating to Left Ventricular Noncompaction Cardiomyopathy: Is the Emperor Still Wearing Any Clothes?
Publication date: June 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 6 Author(s): Robert H. Anderson, Bjarke Jensen, Timothy J. Mohun, Steffen E. Petersen, Nay Aung, Filip Zemrak, R. Nils Planken, David H. MacIver The evidence is increasing that left ventricular noncompaction cardiomyopathy as it is currently defined does not represent a failure of compaction of pre-existing trabecular myocardium found during embryonic development to form the compact component of the ventricular walls. Neither is there evidence of which we are aware to favour the notion that the entity is a return to a phenotype seen in col...
Source: Canadian Journal of Cardiology - May 24, 2017 Category: Cardiology Source Type: research

LVOT-VTI is a Useful Indicator of Low Ventricular Function in Young Patients
This study indicates that LVOT-VTI can be a useful alternative measure of LV performance in children over 1  year.
Source: Mammalian Genome - May 22, 2017 Category: Genetics & Stem Cells Source Type: research

Whole-genome Sequencing in Familial Cases of Intracranial Atherosclerotic Disease (S36.005)
Conclusions:Compared with conventional case-control association study, whole-genome sequencing simultaneously identifies both rare structural variants and SNVs associated with ICAD. This study improved our understanding on the genetic contribution of stroke in ICAD families. The various novel mutations and structural variant identified indicates the heterogeneity and complexity of ICAD.Disclosure: Dr. Leung has nothing to disclose. Dr. Dong has nothing to disclose. Dr. Ip has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Choy has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Leung, T., Dong, E., Ip, B., Wong, K. S. L., Choy, R. K. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

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