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Cancer: Neuroblastoma

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Total 288 results found since Jan 2013.

Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
This study was aimed to investigate whether knockdown of Id2 in neuronal cells could protect them from hypoxic and ischemic injury both in vitro and in vivo. Flow cytometric analysis was employed to assess neuronal apoptosis in CoCl2-treated neuroblastoma B35 cells engineered to overexpress or knockdown Id2 expression. In vivo knockdown of Id2 was performed in Sprague-Dawley rats by a single intracerebroventricular injection of Cy3-labeled and cholesterol-modified Id2-siRNA. We found that knockdown of Id2 attenuated H/I-induced neuronal apoptosis in vitro while overexpression of Id2 produced an opposite effect. In a rat mo...
Source: Behavioural Brain Research - July 14, 2015 Category: Neurology Authors: Guo L, Yang X, Lin X, Lin Y, Shen L, Nie Q, Ren L, Guo Q, Que S, Qiu Y Tags: Behav Brain Res Source Type: research

Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma.
CONCLUSIONS: NBAT-1 is a novel molecular correlated with ccRCC progression; and it may represent a prognostic biomarker and therapeutic target in renal cancer diagnosis and treatment. PMID: 26097558 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Xue S, Li QW, Che JP, Guo Y, Yang FQ, Zheng JH Tags: Int J Clin Exp Pathol Source Type: research

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors.
Authors: Schwermer M, Lee S, Köster J, van Maerken T, Stephan H, Eggert A, Morik K, Schulte JH, Schramm A Abstract Dysregulation of the cell cycle and cyclin-dependent kinases (cdks) is a hallmark of cancer cells. Intervention with cdk function is currently evaluated as a therapeutic option in many cancer types including neuroblastoma (NB), a common solid tumor of childhood. Re-analyses of mRNA profiling data from primary NB revealed that high level mRNA expression of both cdk1 and its corresponding cyclin, CCNB1, were significantly associated with worse patient outcome independent of MYCN amplification, a strong ...
Source: Oncotarget - June 2, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells.
Abstract The dopamine transporter (DAT) is a key regulator of dopaminergic neurotransmission. As such, proper regulation of DAT expression is important to maintain homeostasis, and disruption of DAT expression can lead to neurobehavioral dysfunction. Based on genomic features within the promoter of the DAT gene, there is potential for DAT expression to be regulated through epigenetic mechanisms, including DNA methylation and histone acetylation. However, the relative contribution of these mechanisms to DAT expression has not been empirically determined. Using pharmacologic and genetic approaches, we demonstrate th...
Source: Neurochemical Research - May 12, 2015 Category: Neuroscience Authors: Green AL, Hossain MM, Tee SC, Zarbl H, Guo GL, Richardson JR Tags: Neurochem Res Source Type: research

Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β.
Authors: Wang M, Liu Y, Zou J, Yang R, Xuan F, Wang Y, Gao N, Cui H Abstract Neuroblastoma is a common childhood malignant tumor originated from the neural crest-derived sympathetic nervous system. A crucial event in the pathogenesis of neuroblastoma is to promote proliferation of neuroblasts, which is closely related to poor survival. However, mechanisms for regulation of cell proliferation and tumorigenicity in neuroblastoma are not well understood. Here, we report that overexpression of TAZ in neuroblastoma BE(2)-C cells causes increases in cell proliferation, self renewal and colony formation, which was restore...
Source: Oncotarget - May 6, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Fenofibrate suppressed proliferation and migration of human neuroblastoma cells via oxidative stress dependent of TXNIP upregulation.
Abstract There are no appropriate drugs for metastatic neuroblastoma (NB), which is the most common extra-cranial solid tumor for childhood. Thioredoxin binding protein (TXNIP), the endogenous inhibitor of ROS elimination, has been identified as a tumor suppressor in various solid tumors. It reported that fenofibrate exerts anti-tumor effects in several human cancer cell lines. However, its detail mechanisms remain unclear. The present study assessed the effects of fenofibrate on NB cells and investigated TXNIP role in its anti-tumor mechanisms. We used MTT assay to detect cells proliferation, starch wound test to...
Source: Biochemical and Biophysical Research communications - March 31, 2015 Category: Biochemistry Authors: Su C, Shi A, Cao G, Tao T, Chen R, Hu Z, Shen Z, Tao H, Cao B, Hu D, Bao J Tags: Biochem Biophys Res Commun Source Type: research

Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway
Abstract Wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, has been reported to exhibit a variety of biological effects including anti-cancer effects. It has a pro-apoptotic role in many cancer types. However, the molecular mechanisms of wogonin in treating neuroblastoma remain elusive. In the present study, two malignant neuroblastoma cell lines (SK-N-BE2 and IMR-32 cells) were treated with different doses of wogonin (0–150 μM). Wogonin showed significant cytotoxic effects in SK-N-BE2 and IMR-32 cells in a dose- and time-dependent manner. Treatment of SK-N-BE2 and IMR-32 cells with 75 μΜ w...
Source: Journal of Molecular Neuroscience - March 5, 2015 Category: Neuroscience Source Type: research

Cullin7 is required for lung cancer cell proliferation and is overexpressed in lung cancer.
In this study, we explored the functional role of Cullin7 in lung cancer cell proliferation and tumorigenesis and determined its expression profile in lung cancer. Knocking down Cullin7 expression by small interfering RNA (siRNA) in lung cancer cells inhibited cell proliferation and elevated the expression of p53, p27, and p21 proteins. The enhanced p53 expression resulted from activation of the DNA damage response pathway. Cullin7 knockdown markedly suppressed xenograft tumor growth in vivo in mice. Moreover, Cullin7 expression was increased in primary lung cancer tissues of humans. Thus, Cullin7 is required for sustained...
Source: Oncology Research - February 26, 2015 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Inhibition of Neuroblastoma Development by Targeting Midkine
Midkine (MDK) is a member of a new family of neurotrophic factors considered as rate-limiting growth and angiogenic factors implicated in the onset, invasion, and metastatic process of neuronal tumors, including neuroblastoma. We showed that all neuroblastoma cell lines highly expressed MDK, indicating that it is a critical player in tumor development, which may henceforth represent an attractive therapeutic target. We showed that the knockdown of MDK expression by siRNA led to a marked and significant decrease in neuroblastoma (IGR-N91 and SH-SY5Y) cell proliferation in vitro. Using a new strategy, we then evaluated the a...
Source: Molecular Cancer Therapeutics - January 13, 2015 Category: Cancer & Oncology Authors: Dianat, N., Le Viet, B., Gobbo, E., Auger, N., Bieche, I., Bennaceur-Griscelli, A., Griscelli, F. Tags: Cancer Biology and Signal Transduction Source Type: research

SH2D5 Associates with BCR to Regulate Rac1-GTP Levels Signal Transduction
SH2D5 is a mammalian-specific, uncharacterized adaptor-like protein that contains an N-terminal phosphotyrosine-binding domain and a C-terminal Src homology 2 (SH2) domain. We show that SH2D5 is highly enriched in adult mouse brain, particularly in Purkinjie cells in the cerebellum and the cornu ammonis of the hippocampus. Despite harboring two potential phosphotyrosine (Tyr(P)) recognition domains, SH2D5 binds minimally to Tyr(P) ligands, consistent with the absence of a conserved Tyr(P)-binding arginine residue in the SH2 domain. Immunoprecipitation coupled to mass spectrometry (IP-MS) from cultured cells revealed a prom...
Source: Journal of Biological Chemistry - December 18, 2014 Category: Chemistry Authors: Gray, E. J., Petsalaki, E., James, D. A., Bagshaw, R. D., Stacey, M. M., Rocks, O., Gingras, A.-C., Pawson, T. Tags: Signal Transduction Source Type: research

Involvement of store-operated Ca2+ entry in activation of AMP-activated protein kinase and stimulation of glucose uptake by M3 muscarinic acetylcholine receptors in human neuroblastoma cells
Publication date: December 2014 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1843, Issue 12 Author(s): Maria C. Olianas , Simona Dedoni , Pierluigi Onali Gq/11-coupled muscarinic acetylcholine receptors (mAChRs) belonging to M1, M3 and M5 subtypes have been shown to activate the metabolic sensor AMP-activated protein kinase (AMPK) through Ca2+/calmodulin-dependent protein kinase kinase-β (CaMKKβ)-mediated phosphorylation at Thr172. However, the source of Ca2+ required for this response has not been yet elucidated. Here, we investigated the involvement of store-operated Ca2+ entry (SOCE) ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 11, 2014 Category: Molecular Biology Source Type: research

Clozapine induces chloride channel-4 expression through PKA activation and modulates CDK5 expression in SH-SY5Y and U87 cells
Conclusions The results of the present study suggest that clozapine's therapeutic effect may include the induction of CLC-4 which is dependent on CREB activation via PKA. We also found that functional knockdown of CLC-4 resulted in reduction of CDK5 expression, which may also be implicated in clozapine's therapeutic effect.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research

l-Carnitine attenuates H2O2-induced neuron apoptosis via inhibition of endoplasmic reticulum stress
Publication date: December 2014 Source:Neurochemistry International, Volume 78 Author(s): Junli Ye , Yantao Han , Xuehong Chen , Jing Xie , Xiaojin Liu , Shunhong Qiao , Chunbo Wang Both oxidative stress and endoplasmic reticulum stress (ER stress) have been linked to pathogenesis of neurodegenerative diseases. Our previous study has shown that l-carnitine may function as an antioxidant to inhibit H2O2-induced oxidative stress in neuroblastoma SH-SY5Y cells. To further explore the neuroprotection of l-carnitine, here we study the effects of l-carnitine on the ER stress response in H2O2-induced SH-SY5Y cell injury. Our re...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research

SOX2 promotes tumorigenicity and inhibits the differentiation of I-type neuroblastoma cells.
In conclusion, our findings indicate an important function for SOX2 in promoting tumorigenicity of I-type neuroblastoma cells and in inhibiting their differentiation, suggesting that SOX2 might be a potential therapeutic target in neuroblastoma. PMID: 25333857 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - October 17, 2014 Category: Cancer & Oncology Authors: Yang S, Zheng J, Xiao X, Xu T, Tang W, Zhu H, Yang L, Zheng S, Dong K, Zhou G, Wang Y Tags: Int J Oncol Source Type: research

Cytoprotective effects of 12-oxo phytodienoic acid, a plant-derived oxylipin jasmonate, on oxidative stress-induced toxicity in human neuroblastoma SH-SY5Y cells
Conclusions These results demonstrated that among jasmonates, only OPDA suppressed oxidative stress-induced death of human neuroblastoma cells, which occurred via activation of the Nrf2 pathway. General significance Plant-derived oxylipin OPDA may have the potential to provide protection against oxidative stress-related diseases.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - October 17, 2014 Category: Biochemistry Source Type: research