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Cancer: Lung Cancer

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Total 49680 results found since Jan 2013.

Targeting the Mammalian Target of Rapamycin in Lung Cancer.
Abstract Lung cancer is the leading cause of cancer death worldwide. Despite advances in its prevention and management, the prognosis of patients with lung cancer remains poor. Therefore, much attention is being given to factors that contribute to the development of this disease, the mechanisms that drive oncogenesis and tumor progression and the search for novel targets that could lead to the development of more effective treatments. One cellular pathway implicated in lung cancer development and progression is that of the mammalian target of rapamycin. Studies involving human tissues have linked lung cancer with ...
Source: The American Journal of the Medical Sciences - October 31, 2016 Category: Journals (General) Authors: Vicary GW, Roman J Tags: Am J Med Sci Source Type: research

Recommendations of the Austrian Working Group on Pulmonary Pathology and Oncology for predictive molecular and immunohistochemical testing in non-small cell lung cancer
SummaryThe introduction of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in the therapy of non-small cell lung cancer (NSCLC) with activating mutations of the EGF receptor has opened a  new area of lung cancer treatment strategies and led to an enthusiastic search for additional genetic aberrations. Genetic drivers such asEML4-ALK (EML4: echinoderm microtubule-associated protein-like 4; ALK: anaplastic lymphoma kinase) and proto-oncogene tyrosine protein kinase transcribed from the ROS1-gene (ROS1) rearrangements have been detected and specific treatment options have been developed. A  new appr...
Source: Memo - Magazine of European Medical Oncology - November 29, 2016 Category: Cancer & Oncology Source Type: research

A novel germline TP53 mutation p.Pro190Arg detected in a patient with lung and bilateral breast cancers.
CONCLUSION: We identified novel germline mutation of TP53. PMID: 28499267 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - May 9, 2017 Category: Biomedical Science Authors: Krześniak M, Butkiewicz D, Rachtan J, Matuszczyk I, Grzybowska E, Rusin M Tags: Adv Med Sci Source Type: research

Expanding the search for significant EGFR mutations in NSCLC outside of the tyrosine kinase domain with next-generation sequencing
AbstractWhile conventional organization of EGFR mutations in non-small cell lung cancer (NSCLC) includes classic lesions sensitive to tyrosine kinase inhibitors (TKI) and variants localized to the tyrosine kinase domain (TKD) in exons 18 –21, next-generation sequencing (NGS) raises the prospect of identifying clinically relevant variants in extra-TKD regulatory regions. NSCLC patients at our institution who received tumor profiling with NGS from 2013 to 2015 were identified. EGFR mutations were arranged based upon their distributi on relative to the TKD. In silico analysis was performed to predict non-synonymous single n...
Source: Medical Oncology - June 1, 2017 Category: Cancer & Oncology Source Type: research

Risk of peripheral edema in cancer patients treated with MEK inhibitors: a systematic review and meta-analysis of clinical trials.
CONCLUSION: This meta-analysis reveals that the use of MEK inhibitors is associated with an increased risk of peripheral edema in cancer patients. Oncologists should be aware of the risk and perform regular assessment. PMID: 28665153 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - July 2, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Text Messaging Interventions on Cancer Screening Rates: A Systematic Review
Conclusions: Text messaging interventions appear to moderately increase screening rates for breast and cervical cancer and may have a small effect on colorectal cancer screening. Benefit was observed in various countries, including resource-poor and non-English-speaking populations. Given the paucity of data, additional research is needed to better quantify the effectiveness of this promising intervention.
Source: Journal of Medical Internet Research - August 24, 2017 Category: General Medicine Authors: Catherine Uy Jennifer Lopez Chau Trinh-Shevrin Simona C Kwon Scott E Sherman Peter S Liang Source Type: research

Impact of tumour motion compensation and delineation methods on FDG PET ‐based dose painting plan quality for NSCLC radiation therapy
ConclusionsThe dose painting plans were more sensitive to segmentation of boost volumes than PET motion compensation in this study sample. Careful consideration of boost target delineation and motion compensation strategies should guide the design of NSCLC dose painting trials.
Source: Australasian Radiology - October 1, 2017 Category: Radiology Authors: Hannah Mary Thomas, Paul E Kinahan, James Jebaseelan E Samuel, Stephen R Bowen Tags: Medical Imaging —Radiation Oncology—Original Article Source Type: research

Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis.
CONCLUSION: We demonstrated that PNA clamping has a higher sensitivity than DS for detecting oncogenic alterations in NSCLC. Our findings suggest that PNA clamping is a more useful method for clinical practice. PMID: 29436188 [PubMed - in process]
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Song JU, Lee J Tags: Yonsei Med J Source Type: research

Inequalities in Cancer Deaths by Age, Gender and Education.
CONCLUSIONS: The results can be useful for economists to define the health priorities in each country, make the financial decisions in economics, and thus contribute to better health, economic growth, as well as effective spending of health expenditures. PMID: 29524371 [PubMed - in process]
Source: Central European Journal of Public Health - March 12, 2018 Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research

On the search for new approaches to cure lung cancer
(Johannes Gutenberg Universitaet Mainz) Protein kinases regulate nearly all processes in cells. If the function of these enzymes is disrupted, often cancer will develop. In particular certain types of deregulated mitogen-activated protein kinases (MAPKs) are believed to be the cause of various types of cancer. In his new research project, cellular biologist Professor Krishnaraj Rajalingam of the Mainz University Medical Center intends to dissect on the molecular level how disturbed MAPKs lead to the generation of tumors.
Source: EurekAlert! - Cancer - June 4, 2018 Category: Cancer & Oncology Source Type: news

Search for the T790M mutation: The need to persevere.
We report 7 cases in which the identification of the T790M mutation required repeated analyses of cell free DNA and/or biopsies over a period of time. In some cases, a positive result was obtained a long time after progressive disease had been diagnosed during treatment with first or second generation EGFR-TKI. We discuss here the different modalities of screening for the T790M mutation and we encourage persevering in this search when no alternative mechanism of resistance has been identified. PMID: 30115389 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - August 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Validating the Use of Census Data on Education as a Measure of Socioeconomic Status in an Occupational Cohort.
CONCLUSION: When individual-level SES indicators are not available for statistical adjustment, area-level SES measures can serve as a reliable surrogate when investigating outcomes that are affected by lifestyle factors such as smoking. PMID: 30451561 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - November 21, 2018 Category: Radiology Tags: Int J Radiat Biol Source Type: research

AACR funds Colorado search for lung conditions that allow growth of cancer
(University of Colorado Anschutz Medical Campus) The American Association for Cancer Research (AACR) announced today that in partnership with the Lung Cancer Initiative at Johnson& Johnson (LCI), it will fund a major grant led by University of Colorado Cancer Center investigators to pinpoint the lung tissue characteristics that allow cancer cells to grow, potentially leading to new strategies to prevent and treat the disease.
Source: EurekAlert! - Cancer - March 6, 2019 Category: Cancer & Oncology Source Type: news

Challenges in implementation of lung cancer screening —radiology requirements
SummaryImplementation of lung cancer screening is a  challenge for radiology. The present short review summarizes major requirements which are needed to ensure high rates of diagnostic accuracy and appropriate protocols for follow-up and invasive work-up. Standardization of procedures, structured reporting, assessment of quality metrics, close multi disciplinary collaboration, and continuous education are essential. Additional quantification of coronary artery calcium and emphysema may provide synergistic medical benefits for a lung cancer screening programme.
Source: Memo - Magazine of European Medical Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

Diagnostic Performance of Perfusion Computed Tomography for Differentiating Lung Cancer from Benign Lesions: A Meta-Analysis.
CONCLUSIONS CT perfusion imaging is a valuable technique for the diagnosis of pulmonary nodules. Lung cancer had higher perfusion and permeability than benign lesions. The evidence suggests blood volume is the best surrogate marker for characterizing the blood supply, while permeability surface has a high specificity in quantifying the vascular permeability. PMID: 31077263 [PubMed - in process]
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research