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Total 19 results found since Jan 2013.

What AI Can See in CT Scans That Humans Can ' t What AI Can See in CT Scans That Humans Can ' t
More can be learned from a chest CT than whether early lung cancer is present.Medscape
Source: Medscape Allergy Headlines - July 25, 2023 Category: Allergy & Immunology Tags: Internal Medicine Commentary Source Type: news

Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
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Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news

Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review
CONCLUSIONS: There is paucity of evidence-based information to guide the routine monitoring of CVID patients without non-infectious complications. Prospective studies are needed to determine the best monitoring practices in this group of patients.PMID:35264237 | DOI:10.1186/s13223-022-00661-7
Source: Clinical Lung Cancer - March 10, 2022 Category: Cancer & Oncology Authors: Erika Yue Lee Stephen Betschel Eyal Grunebaum Source Type: research

Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis
Conclusion In this study, after daily HBOT for 6 days, we identified 11 VOCs which could be divided into two PCs. PC1 (inflammation) showed no significant changes over time, PC2 (methyl alkanes) was significantly reduced after daily exposure for 5 days, to approximately 60% after 2 days’ rest. This suggests that daily HBOT does not induce cumulative damage to the pulmonary system of healthy volunteers, but triggers an adaptive response. Additional studies including more treatment sessions, and perhaps additional systemic parameters on radical oxygen scavengers and inflammatory markers, are necessary to substantiate...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Focused Ultrasound Improves NK-92MI Cells Infiltration Into Tumors
Conclusion In conclusion, we demonstrated that the combination of FUS and microbubbles could increase the NK-92MI cells’ infiltration into tumors in this study. The combination of FUS and NK-92MI had a much better therapeutic effect when compared with the PBS group, but no superior therapeutic effect when compared with the NK-92MI group. In total, FUS and microbubbles can improve NK cells’ infiltration into tumors, but future work is still needed to improve NK-92MI cells’ delivery efficiency for solid tumor treatment. Ethics Statement This study was carried out in accordance with the recommendations...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer
Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review. Introduction Chimeric antigen receptors and engineered T cell receptors (based on previously identified high affinity T cell receptors) function by redirecting T cells to a predefined tumor-specific (or tumor-associated) target. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors ...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Chronic eosinophilic pneumonia after radiation therapy for squamous cell lung cancer
Publication date: Available online 5 August 2017 Source:Respiratory Medicine Case Reports Author(s): Hiromasa Nakayasu, Toshihiro Shirai, Yuko Tanaka, Mika Saigusa Reports of chronic eosinophilic pneumonia (CEP) after radiation therapy are limited to breast cancer. We herein describe a case of CEP after radiation therapy for lung cancer. The patient was a 65-year-old man who had asymptomatic peripheral blood eosinophilia but no history of asthma or allergy. One month after completion of radiation therapy, chest CT scan revealed infiltrates inside the irradiated area, leading to the diagnosis of radiation pneumonitis. His ...
Source: Respiratory Medicine Case Reports - August 6, 2017 Category: Respiratory Medicine Source Type: research

Lambert-eaton myasthenic syndrome in a tertiary neurology centre
Conclusions Our survey confirms that the DELTA-P score is a useful clinical tool to stratify screening for malignancy in patients with LEMS, but suggests that isolated clinical features, such as bulbar or autonomic symptoms, are not necessarily indicative of SCLC-LEMS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Ellul, M., Bonello, M., Wieshmann, U. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Neuromuscular disease, Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Could molecular pathology testing in lung cancer be more cost-effective?
Conclusions Testing only patients being considered for EGFR and ALK inhibitors represented small savings; more significant savings would be achievable if testing algorithms used known associations between clinical biomarkers.
Source: Journal of Clinical Pathology - September 19, 2016 Category: Pathology Authors: Walsh, K., Kheng, Y. C., Oniscu, A., Harrison, D. J., Wallace, W. A. Tags: Immunology (including allergy), Lung cancer (oncology), Molecular biology, Lung cancer (respiratory medicine) Short report Source Type: research

Abstract B23: A phase 1 study in patients with mesothelioma or non small cell lung tumours requiring arginine to assess ADI-PEG 20 with pemetrexed and cisplatin (TRAP study)
Conclusions: The combination was well tolerated, the RP2D is 36mg/m2 ADI-PEG 20 weekly with pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 every 3 weeks. Robust clinical activity has been observed with 78% pt having PR as best response on CT scan, as well as PR and SD in2 pt with sarcomatoid mesothelioma. The tolerability and response / disease control rate suggest that this combination may have clinical utility as first line treatment for these malignancies in ASS1-deficient pt. RP2D expansion cohorts are ongoing for pt with pleural mesothelioma or non-squamous NSCLC.Citation Format: Simon Pacey, James F. Spicer, Pui Ying Ch...
Source: Molecular Cancer Therapeutics - January 7, 2016 Category: Cancer & Oncology Authors: Pacey, S., Spicer, J. F., Chan, P. Y., Hategan, M., Repana, D., Steele, J. P., Schmid, P., Cook, G. J. R., Diaz, M., Johnston, A., Baird, R., Barba, A., Khadeir, R., Sheaff, M., Roca, J., Szyszko, T., Bomalaski, J., Szlosarek, P. W. Tags: Clinical Trials: Poster Presentations - Proffered Abstracts Source Type: research

Paraneoplastic neurological disorders
Paraneoplastic Neurological Disorders (PND) are uncommon but important because they frequently present before a cancer is diagnosed and because they cause severe neurological disability. Current thinking is that they are caused by an autoimmune response to ‘onconeural’ antigens, shared by the tumour and the nervous system, although the precise immunopathogenic mechanism is unknown. It is likely that there is an important cellular immune response as evidenced by the presence of lymphocytic infiltration and activated cytotoxic T lymphocytes, found in the CSF of affected patients. PND may affect any part of the ne...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 9, 2014 Category: Neurosurgery Authors: Rees, J. Tags: Immunology (including allergy), Brain stem / cerebellum, Coma and raised intracranial pressure, Drugs: CNS (not psychiatric), Infection (neurology), Neuromuscular disease, Radiology, Disability, Radiology (diagnostics) NEUROPSYCHIATRY RESEARCH UPDATE Source Type: research

Histological evaluation of preoperative mediastinoscopy lymph node biopsies in non-small cell lung cancer
Conclusions Routine examination of additional levels and immunohistochemical staining of mediastinal lymph nodes biopsies is not required and would not improve the overall negative predictive value of the procedure.
Source: Journal of Clinical Pathology - December 13, 2013 Category: Pathology Authors: Dhaliwal, C. A., Andrews, T. D., Walker, W. S., Wallace, W. A. Tags: Immunology (including allergy), Lung cancer (oncology), Lung cancer (respiratory medicine), Clinical diagnostic tests Short report Source Type: research