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Cancer: Hepatocellular Carcinoma

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Total 1432 results found since Jan 2013.

Aryl Hydrocarbon Receptor Negatively Regulates Expression of the Plakoglobin Gene (Jup)
Plakoglobin is an important component of intercellular junctions, including both desmosomes and adherens junctions, which is known as a tumor suppressor. Although mutations in the plakoglobin gene (Jup) and/or changes in its protein levels have been observed in various disease states, including cancer progression or cardiovascular defects, the information about endogenous or exogenous stimuli orchestrating Jup expression is limited. Here we show that the aryl hydrocarbon receptor (AhR) may regulate Jup expression in a cell-specific manner. We observed a significant suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin ...
Source: Toxicological Sciences - July 10, 2013 Category: Toxicology Authors: Prochazkova, J., Kabatkova, M., Smerdova, L., Pachernik, J., Sykorova, D., Kohoutek, J., Simeckova, P., Hruba, E., Kozubik, A., Machala, M., Vondracek, J. Tags: Research Article Source Type: research

Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2
We previously delineated genes whose promoters are hypomethylated and induced in hepatocellular carcinoma (HCC) patients. The purpose of this study was to establish the players that regulate these genes in liver cancer cells. We performed chromatin immunoprecipitation with methyl-CpG-binding domain protein 2 (MBD2), RNA polymerase II (RNA pol II), CCAAT/enhancer-binding protein alpha (CEBPA) antibodies and methylated DNA immunoprecipitation in HepG2 liver cancer cells treated with scrambled small interfering RNA (siRNA) and siRNA to MBD2 or CEBPA. We then hybridized DNA to microarrays spanning the entire coding sequences, ...
Source: Carcinogenesis - November 29, 2013 Category: Cancer & Oncology Authors: Stefanska, B., Suderman, M., Machnes, Z., Bhattacharyya, B., Hallett, M., Szyf, M. Tags: Original Manuscript Source Type: research

Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma.
Abstract Vitexins, isolated from the seeds of the Chinese herb Vitex negundo, is known to exert antitumor activity in cancer xenograft models and cell lines. The aim of the current study was to examine whether the Akt/forkhead box protein O3a (FOXO3a) pathway mediates the biological effects of purified vitexin compound 1 (VB-1) in hepatocellular carcinoma (HCC) cells. The effect of VB-1 on the viability of the HCC cell lines HepG2, Hep3B, Huh-7 and the human embryonic liver cells L-02 was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Growth inhibition was assess...
Source: International Journal of Molecular Medicine - December 12, 2013 Category: Molecular Biology Authors: Wang J, Zheng X, Zeng G, Zhou Y, Yuan H Tags: Int J Mol Med Source Type: research

Recombinant adenovirus encoding FAT10 small interfering RNA inhibits HCC growth in vitro and in vivo.
Abstract Hepatocellular carcinoma is an aggressive and rapidly fatal malignancy representing the common cancer worldwide. The specific cellular gene involved in carcinogenesis has nor been full charactered. The ubiquitin-like modifier FAT10, a recently reported to be overexpressed in 90% of hepatocellular carcinoma carcinomas, was attributed to transcriptional upregulation upon the loss of p53 and induced chromosome instability in long-term in vitro culture. However, the exact function of FAT10 in Hepatocellular carcinoma is not clear. In the present study, we utilized adenovirus-mediated RNA interference to knock...
Source: Experimental and Molecular Pathology - January 14, 2014 Category: Pathology Authors: Chen J, Zi W, Yang Z Tags: Exp Mol Pathol Source Type: research

Isoquercitrin activates the AMP-activated protein kinase (AMPK) signal pathway in rat H4IIE cells
Conclusions: Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation. These results suggest that isoquercitrin is a novel dietary compound that can be potentially be used to prevent lipid metabolic disorder and nonalcoholic fatty liver disease.
Source: BMC Complementary and Alternative Medicine - February 3, 2014 Category: Complementary Medicine Authors: Jingxin ZhouHisae YoshitomiTonghua LiuBoxin ZhouWen SunLingling QinXiangyu GuoLiansha HuangLili WuMing Gao Source Type: research

Isoquercitrin activates the AMP¿activated protein kinase (AMPK) signal pathway in rat H4IIE cells
Conclusions: Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation. These results suggest that isoquercitrin is a novel dietary compound that can be potentially be used to prevent lipid metabolic disorder and nonalcoholic fatty liver disease.
Source: BMC Complementary and Alternative Medicine - February 3, 2014 Category: Complementary Medicine Authors: Jingxin ZhouHisae YoshitomiTonghua LiuBoxin ZhouWen SunLingling QinXiangyu GuoLiansha HuangLili WuMing Gao Source Type: research

Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells.
Abstract Sorafenib, the first-line systemic drug for advanced hepatocellular carcinoma (HCC), has demonstrated limited benefits with very low response rates. Thus it is essential to investigate the underlying mechanisms for the resistance to sorafenib and seek potential strategy to enhance its efficacy. Hypoxic cells inside solid tumors are extremely resistant to therapies as their survival ability is increased due to the cellular adaptive response to hypoxia, which is controlled by hypoxia-inducible factor (HIF)-1 and HIF-2. Sorafenib inhibits HIF-1α synthesis, making the hypoxic response switch from HIF-1α- to...
Source: Cellular Signalling - January 29, 2014 Category: Cytology Authors: Zhao D, Zhai B, He C, Tan G, Jiang X, Pan S, Dong X, Wei Z, Ma L, Qiao H, Jiang H, Sun X Tags: Cell Signal Source Type: research

The role of HMGB1-RAGE axis in migration and invasion of hepatocellular carcinoma cell lines.
Abstract High mobility group protein box1 (HMGB1) and its receptor-receptor for advanced glycation end products (RAGE) are pivotal factors in the development and progression of many types of tumor, but the role of HMGB1-RAGE axis in hepatocellular carcinoma (HCC) especially its effects on metastasis and recurrence remains obscure. Here, we report the role of HMGB1-RAGE axis in the biological behaviors of HCC cell lines and the underlying molecular mechanism. We show that the expressions of HMGB1, RAGE, and extracellular HMGB1 increase consistently according to cell metastasis potentials, while the concentration of...
Source: Molecular and Cellular Biochemistry - February 9, 2014 Category: Biochemistry Authors: Chen RC, Yi PP, Zhou RR, Xiao MF, Huang ZB, Tang DL, Huang Y, Fan XG Tags: Mol Cell Biochem Source Type: research

Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress.
Abstract Anacardic acid (6-pentadecylsalicylic acid, AA), a natural compound isolated from the traditional medicine Amphipterygium adstringens, has been reported to possess antitumor activities. However, its molecular targets have not been thoroughly studied. Here, we report that AA is a potent inducer of endoplasmic reticulum (ER) stress, leading to apoptosis in hepatoma HepG2 and myeloma U266 cells. Induction of ER stress by AA was supported by a dose- and time-dependent increase in expression of the ER signaling downstream molecules, such as GRP78/BiP, phosphorylated eIF2α, ATF4 and CHOP in both HepG2 and U266...
Source: Toxicology Letters - May 19, 2014 Category: Toxicology Authors: Huang H, Hua X, Liu N, Li X, Liu S, Chen X, Zhao C, Lan X, Yang C, Dou QP, Liu J Tags: Toxicol Lett Source Type: research

14-3-3sigma induces heat shock protein 70 expression in hepatocellular carcinoma
Conclusions: Our findings indicate that 14-3-3sigma participates in promoting HCC cell migration and tumor development via beta-catenin/HSF-1alpha/HSP70 pathway regulation. Thus, 14-3-3sigma alone or combined with HSP70 are potential prognostic biomarkers for HCC.
Source: BMC Cancer - June 12, 2014 Category: Cancer & Oncology Authors: Chia-Chia LiuYee-Jee JanBor-Sheng KoYao-Ming WuShu-Man LiangShyh-Chang ChenYen-Ming LeeTzu-An LiuTzu-Ching ChangJohn WangSong-Kun ShyueLi-Ying SungJun-Yang Liou Source Type: research

Inhibition of tumor growth by U0126 is associated with induction of interferon‐γ production
In this study, we determined that U0126, a MEK1/2 inhibitor, increased tumor‐free and survival rates and decreased growth of inoculated Lewis lung carcinomas in wild type mice. However, the protective effects were substantially attenuated in IFN‐γ deficient (IFN‐γ‐/‐) mice. At cellular and molecular levels, MEK1/2 inhibitors increased IFN‐γ protein and mRNA expression, activated natural IFN‐γ promoter but not the IFN‐γ promoters with mutations of the LXR responsive elements (LXREs). MEK1/2 inhibitors also enhanced formation of the LXRE‐nuclear protein complexes by inducing LXR expression and nuclear ...
Source: International Journal of Cancer - June 20, 2014 Category: Cancer & Oncology Authors: Xingzhe Ma, Qixue Wang, Ying Liu, Yuanli Chen, Ling Zhang, Meixiu Jiang, Xiaoju Li, Rong Xiang, Robert Q Miao, Yajun Duan, Jihong Han Tags: Cancer Cell Biology Source Type: research

Chloride intracellular channel 1 participates in migration and invasion of hepatocellular carcinoma by targeting maspin
ConclusionsCLIC1 protein expression is significantly correlated with vascular invasion, and the present study suggests a previously unknown mechanism of CLIC1‐mediated control of HCC invasiveness by targeting maspin.
Source: Journal of Gastroenterology and Hepatology - July 2, 2014 Category: Gastroenterology Authors: Xuyong Wei, Jie Li, Haiyang Xie, Hangxiang Wang, Jianguo Wang, Xuanyu Zhang, Runzhou Zhuang, Di Lu, Qi Ling, Lin Zhou, Xiao Xu, Shusen Zheng Tags: Experimental Hepatology Source Type: research

Isoform-Selective HDAC2 RNAi Targeting in HCC cells
In this study, we show that specific targeting of this HDAC isoform is sufficient to inhibit HCC progression. siRNA-mediated silencing of HDAC inhibited HCC cell growth by blocking cell-cycle progression and inducing apoptosis. These effects were associated with deregulation of HDAC-regulated genes that control cell cycle, apoptosis, and lipid metabolism, specifically, by upregulation of p27 and acetylated p53 and by downregulation of CDK6 and BCL2. We found that HDAC2 silencing in HCC cells also strongly inhibited PPARγ signaling and other regulators of glycolysis (ChREBPα and GLUT4) and lipogenesis (SREBP1C and FAS), e...
Source: Cancer Research - September 1, 2014 Category: Cancer & Oncology Authors: Lee, Y.–H., Seo, D., Choi, K.–J., Andersen, J. B., Won, M.–A., Kitade, M., Gomez–Quiroz, L. E., Judge, A. D., Marquardt, J. U., Raggi, C., Conner, E. A., MacLachlan, I., Factor, V. M., Thorgeirsson, S. S. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
Abstract Hepatitis C virus (HCV) is a positive-strand RNA virus responsible for chronic liver disease and hepatocellular carcinoma (HCC). Rac GTPase-activating protein 1 (RacGAP1) plays an important role during GTP hydrolysis to GDP in Rac1 and CDC42 protein and has been demonstrated to be upregulated in several cancers, including HCC. However, the molecular mechanism leading to the upregulation of RacGAP1 remains poorly understood. Here, we showed that RacGAP1 levels were enhanced in HCV cell-culture-derived (HCVcc) infection. More importantly, we illustrated that RacGAP1 interacts with the viral protein NS5B in ...
Source: Biochemical and Biophysical Research communications - October 8, 2014 Category: Biochemistry Authors: Wu MJ, Ke PY, Horng JT Tags: Biochem Biophys Res Commun Source Type: research

Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through RET
Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world with poor prognosis. Here, we investigated the role of microRNA 218 (miR-218) in regulating human HCC development. Quantitative PCR (qPCR) was used to compare the expression levels of miR-218 between eight HCC and a normal liver cell lines, as well as nine primary HCC tissues and adjacent non-carcinoma tissues. HCC cell lines MHCC97L and Huh7 were transfected with lentiviral vector of miR-218 mimics. The effect of miR-218 overexpression on cancer cell growth, both in vitro and in vivo, as well as cancer cell invasion was examined....
Source: Tumor Biology - November 6, 2014 Category: Cancer & Oncology Source Type: research