Filtered By:
Specialty: Neurology
Cancer: Brain Cancers
Education: Study
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 226 results found since Jan 2013.
Altered Brain Structural Networks in Patients with Brain Arteriovenous Malformations Located in Broca's Area.
In this study, we used diffusion tensor imaging and graph theory methods to investigate the alterations of brain structural networks in 14 patients with AVMs in the presumed Broca's area, compared to 27 normal controls. Weighted brain structural networks were constructed based on deterministic tractography. We compared the topological properties and network connectivity between patients and normal controls. Functional magnetic resonance imaging revealed contralateral reorganization of Broca's area in five (35.7%) patients. Compared to normal controls, the patients exhibited preserved small-worldness of brain structural net...
Source: Neural Plasticity - November 13, 2020 Category: Neurology Authors: Li M, Jiang P, Wu J, Guo R, Deng X, Cao Y, Wang S Tags: Neural Plast Source Type: research
Language Mapping With Magnetoencephalography: An Update on the Current State of Clinical Research and Practice With Considerations for Clinical Practice Guidelines
Summary:
Numerous studies have shown that language processing is not limited to a few brain areas. Visual or auditory stimuli activate corresponding cortical areas, then memory identifies the word or image, Wernicke's and Broca's areas support the processing for either reading/listening or speaking and many areas of the brain are recruited. Determining how a normal person processes language helps clinicians and scientist to understand how brain pathologies such as tumor or stroke can affect changes in language processing. Patients with epilepsy may develop atypical language organization. Over time, the chronic nature o...
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research
Visual Mapping With Magnetoencephalography: An Update on the Current State of Clinical Research and Practice With Considerations for Clinical Practice Guidelines
Summary:
Using visual evoked fields (VEFs) to differentiate healthy, normal brain function from dysfunctional cortex has been demonstrated to be both valid and reliable. Currently, VEFs are widely implemented to guide intracranial surgeries for epilepsy and brain tumors. There are several areas of possible future clinical use of VEFs, including early identification of disorders, such as multiple sclerosis, Parkinson's disease, stroke, and human immunodeficiency virus–associated neurocognitive disorders. These studies have suggested that VEFs could be used to study disease pathophysiology or as a biomarker for early i...
Source: Journal of Clinical Neurophysiology - November 1, 2020 Category: Neurology Tags: Invited Review Source Type: research
Cerebral Autoregulation and Neurovascular Coupling after Craniospinal Irradiation in Long-Term Survivors of Malignant Pediatric Brain Tumors of the Posterior Fossa
Conclusion In this pilot study, we demonstrated a trend toward reduced cerebral autoregulation, and no alteration of neurovascular coupling after irradiation in long-term survivors of malignant pediatric brain tumors of the posterior fossa. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Neuropediatrics - October 16, 2020 Category: Neurology Authors: Janzarik, Wibke G. Sander, Milena R ößler, Jochen Sommerlade, Linda Allignol, Arthur Reinhard, Matthias Tags: Original Article Source Type: research
Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival
AbstractThe cytolytic protein perforin has a crucial role in infections and tumor surveillance. Recently, it has also been associated with many brain diseases, such as neurodegenerative diseases and stroke. Therefore, inhibitors of perforin have attracted interest as novel drug candidates. We have previously reported that converting a perforin inhibitor into an L-type amino acid transporter 1 (LAT1)-utilizing prodrug can improve the compound ’s brain drug delivery not only across the blood–brain barrier (BBB) but also into the brain parenchymal cells: neurons, astrocytes, and microglia. The present study evaluated whet...
Source: Molecular Neurobiology - September 24, 2020 Category: Neurology Source Type: research
Astrocytic Yes-associated protein attenuates cerebral ischemia-induced brain injury by regulating signal transducer and activator of transcription 3 signaling.
In this study, we investigated whether the expression of nuclear YAP in the astrocytes of rats increased significantly after middle cerebral artery occlusion (MCAO) and its effect on cerebral ischemic injury. We used XMU-MP-1 to trigger localization of YAP into the nucleus and found that XMU-MP-1 treatment decreased ischemia/stroke-induced brain injury including reduced neuronal death and reactive astrogliosis, and extenuated release of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Mechanically, XMU-MP-1 treatment suppressed the expression of phospho-STAT3 (P-STAT3). We established ...
Source: Experimental Neurology - July 31, 2020 Category: Neurology Authors: Huang L, Li S, Dai Q, Zhang A, Yu Q, Du W, Zhao P, Mo Y, Xu K, Chen S, Wang J Tags: Exp Neurol Source Type: research
Mixed Lineage Leukemia 1 Promoted Neuron Apoptosis in Ischemic Penumbra via Regulating ASK-1/TNF- α Complex
This study aimed to explore the underlying mechanism of neuron apoptosis in ischemic penumbra via histone methyltransferase (HMT) mixed lineage leukemia 1 (MLL1) mediated epigenetic pathway. Mouse IS model was established by middle cerebral artery occlusion (MCAO). Mouse primary cortical mixed cells were cultured and treated with oxygen–glucose deprivation (OGD) to simulate IS process. The expressions of apoptosis signal regulating kinase-1 (ASK-1), pASK-1, cleaved caspase-3, ASK-1/serine–threonine kinase receptor-associated protein (STRAP)/14-3-3 complex, ASK-1/tumor necrosis factor-α (TNF-α) complex, and MLL1 in mo...
Source: Frontiers in Neuroanatomy - July 24, 2020 Category: Neurology Source Type: research
Stroke-like migraine attacks after radiation therapy (SMART) syndrome —a case series and review
ConclusionOur extensive review favors MRI, CT, and prolonged EEG monitoring to rule out other differentials and showed that initiation of corticosteroid therapy and antiepileptic treatment were helpful in the resolution of symptoms and prevent recurrences. Therefore, future studies should be focused on early identification and management guidelines for SMART syndrome.
Source: Neurological Sciences - July 12, 2020 Category: Neurology Source Type: research
A Polyphenolic Complex Attenuates Inflammatory Response and Blood-Brain Barrier Disruption.
Abstract
BACKGROUND: Cerebral ischemia causes strong inflammatory response. Neumentix is a dietary supplement containing 14.9% rosmarinic acid and 29.9% total phenolic content, which was proved to be beneficial against inflammatory response. Therefore, we investigated Neumentix's effect on anti-inflammatory and blood brain barrier (BBB) disruption in transient middle cerebral artery occlusion (tMCAO) model mice.
METHODS: After the pretreatment of vehicle or Neumentix 134 mg/kg/d, intraperitoneal injection (i.p.) (containing rosmarinic acid 20mg/kg/d) for 14 days, mice were subjected to tMCAO for 60 min and ke...
Source: Current Neurovascular Research - May 15, 2020 Category: Neurology Authors: Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura E, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K Tags: Curr Neurovasc Res Source Type: research
Gene –disease association study of tumor necrosis factor‐α G‐308A gene polymorphism with risk of major depressive disorder: A systematic review and meta‐analysis
ConclusionNeither the allele frequencies nor genotypes of TNF ‐α G‐308A gene could be served as an independent risk factor of depression.
Source: Brain and Behavior - April 18, 2020 Category: Neurology Authors: Xin Wang,
Hongxiu Zhang,
Xianling Cao,
Wei Shi,
Xiaoyu Zhou,
Qian Chen,
Ke Ma Tags: REVIEW ARTICLE Source Type: research
Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion.
In this study, we investigated whether donepezil could promote SVZ neurogenesis in chronic cerebral hypoperfusion (CCH) injury via Src signaling pathway. In the bilateral carotid artery occlusion (2VO) rat model, we observed more nestin/5-bromo-2'-deoxyuridine (BrdU)-positive cells and doublecortin (DCX)/BrdU-positive cells in the SVZ than that in the sham group. Further, donepezil obviously improved neurologic function after 2VO, induced the greater number of SVZ proliferative NSCs and neuroblasts, and elevated levels of Src, p-FGFR1, p-EGFR, p-Akt and p-Raf in ipsilateral SVZ. Lastly, Src inhibitor KX-01 abolished the be...
Source: Brain Research - March 13, 2020 Category: Neurology Authors: Man J, Cui K, Fu X, Zhang D, Lu Z, Gao Y, Yu L, Li N, Wang J Tags: Brain Res Source Type: research
Transcutaneous Electrical Nerve Stimulation in Relieving Neuropathic Pain: Basic Mechanisms and Clinical Applications
AbstractPurpose of ReviewTranscutaneous electrical nerve stimulation (TENS) is widely used as a non-pharmacological approach for pain relief in a variety of clinical conditions. This manuscript aimed to review the basic mechanisms and clinical applications regarding the use of TENS for alleviating the peripheral (PNP) and central neuropathic pain (CNP).Recent FindingsBasic studies on animal models showed that TENS could alleviate pain by modulating neurotransmitters and receptors in the stimulation site and its upper levels, including the spinal cord, brainstem, and brain. Besides, many clinical studies have investigated t...
Source: Current Pain and Headache Reports - February 17, 2020 Category: Neurology Source Type: research
The combined association of depressive symptoms and C-reactive protein for incident disease risk up to 12 years later. Findings from the English Longitudinal of Ageing (ELSA)
ConclusionA combination of depressive symptoms and CRP was implicated in the onset of CHD, stroke, diabetes/high blood glucose, and pulmonary disease up to 12 years later, reflecting the role of psychobiological processes across multiple disease states.
Source: Brain, Behavior, and Immunity - January 21, 2020 Category: Neurology Source Type: research
The combined association of depressive symptoms and C-reactive protein for incident disease risk up to 12 years later. Findings from the English Longitudinal of Ageing (ELSA).
CONCLUSION: A combination of depressive symptoms and CRP was implicated in the onset of CHD, stroke, diabetes/high blood glucose, and pulmonary disease up to 12 years later, reflecting the role of psychobiological processes across multiple disease states.
PMID: 31972338 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - January 19, 2020 Category: Neurology Authors: Poole L, Steptoe A Tags: Brain Behav Immun Source Type: research
New-onset refractory status epilepticus: a retrospective cohort study
Status epilepticus (SE) is a neurological emergency with more than 180 described causes; common causes include medication change or noncompliance in patients with known epilepsy, toxic-metabolic disturbances, sedative/hypnotic withdrawal, acute/remote stroke, and brain tumor [1]. The term new-onset refractory SE (NORSE) is applied to a patient without a prior diagnosis of epilepsy or other preexisting relevant neurological disorder, with new onset of refractory SE (RSE) that does not respond to first- and second-line antiseizure drugs and no clear acute or active structural, toxic, or metabolic cause.
Source: Seizure: European Journal of Epilepsy - December 2, 2019 Category: Neurology Authors: James J. Gugger, Khalil Husari, John C. Probasco, Mackenzie C. Cervenka Source Type: research
