A Polyphenolic Complex Attenuates Inflammatory Response and Blood-Brain Barrier Disruption.

A Polyphenolic Complex Attenuates Inflammatory Response and Blood-Brain Barrier Disruption.
Curr Neurovasc Res. 2020 May 16;:
Authors: Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura E, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K
Abstract
BACKGROUND: Cerebral ischemia causes strong inflammatory response. Neumentix is a dietary supplement containing 14.9% rosmarinic acid and 29.9% total phenolic content, which was proved to be beneficial against inflammatory response. Therefore, we investigated Neumentix's effect on anti-inflammatory and blood brain barrier (BBB) disruption in transient middle cerebral artery occlusion (tMCAO) model mice.
METHODS: After the pretreatment of vehicle or Neumentix 134 mg/kg/d, intraperitoneal injection (i.p.) (containing rosmarinic acid 20mg/kg/d) for 14 days, mice were subjected to tMCAO for 60 min and kept receiving vehicle or Neumentix daily 5 days afterwards.
RESULTS: Neumentix treatment ameliorated neurobehavioral impairment in the corner test (5d after tMCAO, **p<0.01), reduced infarct volume (#p<0.05), suppressed expression of ionized calcium-binding adapter molecule-1 (Iba-1), tumor necrosis factor alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) (### p <0.001), and improved the integrity of BBB (§p<0.05) at the 5 days after tMCAO. Conclusios: Our present study provided an evi...

Source: Current Neurovascular Research - May 15, 2020 Category: Neurology Authors: Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura E, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K Tags: Curr Neurovasc Res Source Type: research