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Total 427 results found since Jan 2013.

Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder
Conclusions: In this study population, associations between pesticide exposures and ASD were attenuated among those with high versus low FA intake during the first month of pregnancy. Confirmatory and mechanistic studies are needed. https://doi.org/10.1289/EHP604 Received: 07 June 2016 Revised: 16 March 2017 Accepted: 18 March 2017 Published: 08 September 2017 Address correspondence to R. J. Schmidt, 123 Medical Sciences 1C, One Shields Ave., Davis, CA 95616-8638 USA; Telephone: (530) 752-3226. Email: rjschmidt@ucdavis.edu *Current address: Department of Mental Health, Wendy Klag Center for Autism and Developmental D...
Source: EHP Research - September 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population
Conclusion: Rice consumption may be related to the occurrence of SCC in the United States, especially among those with relatively low drinking water arsenic exposure. https://doi.org/10.1289/EHP1065 Received: 06 September 2016 Revised: 04 July 2017 Accepted: 06 July 2017 Published: 07 September 2017 Address correspondence to M.R. Karagas, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756 USA. Telephone: (603) 653-9010. Email: Margaret.R.Karagas@dartmouth.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1065). The authors declare they have no actual ...
Source: EHP Research - September 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Cancer Incidence and Etiology in the Active Duty Population of U.S. Military
CONCLUSIONS: The etiology of cancer within ADS remains largely unknown. A number of new research programs may provide the means to improve understanding of the etiology of cancer in ADS. Together, these efforts will improve prevention, early detection, and clinical management, thus improving the outcomes of ADS and preserving force readiness.PMID:36239575 | DOI:10.1093/milmed/usac297
Source: Military Medicine - October 14, 2022 Category: International Medicine & Public Health Authors: Leann A Lovejoy Craig D Shriver Rachel E Ellsworth Source Type: research

Modern aspects of the use of natural polyphenols in tumor prevention and therapy
Front Cell Dev Biol. 2022 Sep 12;10:1011435. doi: 10.3389/fcell.2022.1011435. eCollection 2022.ABSTRACTPolyphenols are secondary plant metabolites or organic compounds synthesized by them. In other words, these are molecules that are found in plants. Due to the wide variety of polyphenols and the plants in which they are found, these compounds are divided according to the source of origin, the function of the polyphenols, and their chemical structure; where the main ones are flavonoids. All the beneficial properties of polyphenols have not yet been studied, since this group of substances is very extensive and diverse. Howe...
Source: Cancer Control - September 29, 2022 Category: Cancer & Oncology Authors: Galina Sufianova Ilgiz Gareev Ozal Beylerli Jianing Wu Alina Shumadalova Albert Sufianov Xin Chen Shiguang Zhao Source Type: research

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation
Conclusion It was showed that e-As4S4 could alleviate the metastatic features of aggressive breast cancers through correcting the tumor microenvironment, which prolonged the survival of tumor-bearing mice, showing its important therapeutic implications to the anti-metastasis therapy for breast cancer. Ethics Statement Six-week-old, female BALB/c mice were bred at the Experimental Animal Center at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (Beijing, China) under specific pathogen-free conditions. All the animal experiments reported herein were carried out in compliance with the regulatio...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

In vitro and in vivo antimelanoma effect of ethyl ester cyclohexyl analog of ethylenediamine dipropanoic acid
Melanoma, an aggressive skin tumor with high metastatic potential, is associated with high mortality and increasing morbidity. Multiple available chemotherapeutic and immunotherapeutic modalities failed to improve survival in advanced disease, and the search for new agents is ongoing. The aim of this study was to investigate antimelanoma effects of O,O-diethyl-(S,S)-ethylenediamine-N,N′di-2-(3-cyclohexyl) propanoate dihydrochloride (EE), a previously synthesized and characterized organic compound. Mouse melanoma B16 cell viability was assessed using acid phosphatase, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium b...
Source: Melanoma Research - December 20, 2017 Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Basic science Source Type: research

A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression
Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Janssen Highlights Commitment to Advancing Transformative Innovations in Oncology with Scientific Updates from Deep, Diverse Pipeline and Portfolio at ASCO and EHA Virtual Scientific Programs
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 30 company-sponsored studies, including six oral presentations, will be featured during the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8. Janssen presentations will include new data and updates for both approved and investigational therapeutics that are being studied for the treatment of various solid tumors and blood cancers. Immediately following ASCO, additional data will be featured during the European Hematology Association (EHA) Virtual Congress, June 9-17. A comp...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats
This study was carried out in strict accordance with recommendations of the National Institutes of Health guide for the care and use of Laboratory animals. Before undergoing the experimental work, the protocol was approved by the Comité Institutionnel de Protection des Animaux (CIPA) of UQAM (Permit Number: 0515-R3–759-0516). After a 3-day acclimatization period at UQAM’s animal facility, young (100–125 g; approximately 4 weeks old) male Wistar rats (Charles River, St-Constant, QC, Canada) were randomly fed with a regular chow diet (RCD; n = 13) or HFD (n ...
Source: Frontiers in Physiology - April 9, 2019 Category: Physiology Source Type: research

Inula Viscosa Extract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo Through Induction of Apoptosis
In conclusion, the present study indicated that IV aqueous leaf extract, affects the cell cycle progression and induces apoptosis by activation of caspases in colon cancer cells. Moreover, IV extract exhibits anti-tumor activities in an animal model, and it is safe for use. It can be suggested that IV aqueous leaf extract may serve as a strong potential drug for the treatment and probably for prevention of cancer. Ethics Statement All the experimental animal studies were conducted in accordance with the valid international guidelines after approval by the Animal Ethics Committee at the Technion Institute (Haifa, Israel) ...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Targeted Delivery of Chlorin e6 via Redox Sensitive Diselenide-Containing Micelles for Improved Photodynamic Therapy in Cluster of Differentiation 44-Overexpressing Breast Cancer
Conclusions In this study, we developed a minimalist photosensitizer delivery system. HA-sese-Ce6 micelles showed targeted, redox sensitive delivery of Ce6 to 4T1 breast cancer cells. The therapeutic effect of this method could be maximized via positive feedback because the activated Ce6 generates singlet oxygen molecules, which helps to break more diselenide bonds on the micelles. These characteristics were confirmed in 4T1 mice breast cancer cells and in vivo 4T1 tumor bearing mice models. This unique HA-sese-Ce6 micelles exhibited a great anti-cancer effect and metastasis inhibition. We believe that this can be a promi...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives
Conclusions Based on the structure of sanguinarine, fourteen phenanthridine derivatives 8a-m were synthesized and evaluated for their cytotoxic activity against five different human cancer cell lines. Among the evaluated compounds, 8a exhibited a broad spectrum of anti-proliferative activities against all the tested cancer cell lines. Further mechanistic assay revealed that compound 8a could inhibit the activity of both DNA Top I and Top II, as well as preventing cell transition from S to G2 phase dose-dependently. Apoptosis studies against MCF-7 cells indicated that downregulation of Bcl-2 and upregulation of Bax express...
Source: Frontiers in Oncology - April 15, 2019 Category: Cancer & Oncology Source Type: research

Phytofabrication of Selenium Nanoparticles From Emblica officinalis Fruit Extract and Exploring Its Biopotential Applications: Antioxidant, Antimicrobial, and Biocompatibility
Conclusion The present study shows phytofabrication of SeNPs from aqueous fruit extract of E. officinalis by facile, green, economic, and eco-friendly approach. The aqueous fruit extract of E. officinalis was rich with phenolics, flavonoids, and tannins, and was found appropriate for biosynthesis of nanoparticles. The synthesized PF-SeNPs exhibited highly stable, negative charge, amorphous nature, spherical shape and nano-size. The PF-SeNPs has presented efficient bio-potential applications, i.e., antioxidant, antimicrobial, and biocompatibility. The PF-SeNPs has shown potent free radical scavenging activity and it was fo...
Source: Frontiers in Microbiology - April 29, 2019 Category: Microbiology Source Type: research