A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression
A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulated by protein kinase C-phosphorylation or by binding to the calcium sensor calmodulin (CaM). GAP43, MARCKS, and BASP1 are also expressed in non-neuronal cells, where they may have important functions to manage cytoskeleton architecture, and in case of MARCKS and BASP1 to act as cofactors in transcriptional regulation. During neoplastic cell transformation, the proteins reveal differential expression in normal vs. tumor cells, and display intrinsic tumor promoting or tumor suppressive activities. Whereas GAP43 and MARCKS are oncogenic, tumor suppressive functions have been ascribed to BASP1 and in part to MARCKS depending on the cell type. Like MARCKS, the myristoylated BASP1 protein is localized both in the cytoplasm and in the cell nucleus. Nuclear BASP1 participate...
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part BAuthor(s): Yanhua Liu, Yang Li, Shanshan Dong, Lu Han, Ruixin Guo, Yourong Fu, Shenghu Zhang, Jianqiu Chen
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part AAuthor(s): Cheng Han, Yinping Zhang, Marc Redmile-Gordon, Huan Deng, Zhenggui Gu, Qiguo Zhao, Fang Wang
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part AAuthor(s): Peter A. Bain, Adrienne Gregg, Alok K. Pandey, Mohana Krishna Reddy Mudiam, Peta A. Neale, Anu Kumar
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part AAuthor(s): Jinquan Chen, Xuan Li, Wei Jia, Shili Shen, Shengjiong Deng, Bohua Ji, Junjun Chang
Publication date: Available online 30 September 2020Source: Journal of Hazardous MaterialsAuthor(s): Anthony Beauvois, Delphine Vantelon, Jacques Jestin, Martine Bouhnik-Le Coz, Charlotte Catrouillet, Valérie Briois, Thomas Bizien, Mélanie Davranche
Authors: Musio F Abstract INTRODUCTION: Anemia has and will continue to be a central theme in medicine particularly as clinicians are treating a burgeoning population of complex multi-organ system processes. As a result of multiple randomized controlled trials (RCTs), meta-analyses, and societal recommendations overly restrictive paradigms and under-administration of erythropoiesis stimulating agents (ESAs) have likely been followed by clinicians among all specialties. AREAS COVERED: A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the e...
Publication date: January 2021Source: Urology Case Reports, Volume 34Author(s): Nina Al-Saadi, Safa Al-Musawi, Yousuf Khan, Daben Dawam
Publication date: Available online 10 October 2020Source: European UrologyAuthor(s): Stanley Weng, Renzo G. DiNatale, Andrew Silagy, Roy Mano, Kyrollis Attalla, Mahyar Kashani, Kate Weiss, Nicole E. Benfante, Andrew G. Winer, Jonathan A. Coleman, Victor E. Reuter, Paul Russo, Ed Reznik, Satish K. Tickoo, A. Ari Hakimi
CONCLUSIONS: Immunohistochemistry seems to be a promising option not only in clinical recognition, but also in the selection and monitoring of treatment effects. However, these methods have not yet recommended for routine clinical use. PMID: 33032462 [PubMed - as supplied by publisher]
[Unilateral Irregularities in the Macular Pigment Epithelium in a 38-Year-Old Patient - "Acute Retinal Pigment Epitheliitis"]. Klin Monbl Augenheilkd. 2020 Oct 09;: Authors: Wykrota AA, Löw U, Fries FN, Seitz B, Abdin AD PMID: 33036057 [PubMed - as supplied by publisher]
More News: Acute Leukemia | Acute Myeloid Leukemia | Addison's Disease | Adenocarcinoma | Asthma | Astrocytoma | Austria Health | Bile Duct Cancer | Biochemistry | Biology | Biotechnology | Bird Flu | Brain | Brain Cancers | Brain Tumor | Breast Cancer | Breast Carcinoma | Bronchial Tumour | Burns | Calcium | Cancer | Cancer & Oncology | Cancer Therapy | Cancer Vaccines | Carcinoma | Cervical Cancer | Chemistry | Cholangiocarcinoma | Chronic Leukemia | Chronic Lymphocytic Leukemia | Chronic Myeloid Leukaemia | Colon Cancer | Colorectal Cancer | Databases & Libraries | Diabetes | Embryonal Carcinoma | Endocrinology | Epithelial Cancer | Eye Cancers | Funding | Genetics | Glioma | Grants | Hepatocellular Carcinoma | Immunotherapy | Inflammatory Breast Cancer | Insulin | Kidney Cancer | Learning | Leukemia | Liver | Liver Cancer | Lung Cancer | Lymphoma | Melanoma | Molecular Biology | Myelodysplastic Syndrome | Myeloma | Nanotechnology | Neuroblastoma | Neurology | Neuroscience | Non-Small Cell Lung Cancer | Organic | Ovarian Cancer | Ovaries | PET Scan | Physiology | Prostate Cancer | Renal Cell Carcinoma | Sarcomas | Science | Skin | Skin Cancer | Small Cell Lung Cancer | Squamous Cell Carcinoma | Stem Cell Therapy | Stem Cells | Study | T-cell Lymphoma | Tamoxifen | Thyroid | Thyroid Cancer | Translocation | Universities & Medical Training | Urology & Nephrology | Uveal Melanoma | Vaccines | Velcade | Veterinary Vaccinations | Vitamin A | Wilm's Tumor | Zinc