Inula Viscosa Extract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo Through Induction of Apoptosis

In conclusion, the present study indicated that IV aqueous leaf extract, affects the cell cycle progression and induces apoptosis by activation of caspases in colon cancer cells. Moreover, IV extract exhibits anti-tumor activities in an animal model, and it is safe for use. It can be suggested that IV aqueous leaf extract may serve as a strong potential drug for the treatment and probably for prevention of cancer. Ethics Statement All the experimental animal studies were conducted in accordance with the valid international guidelines after approval by the Animal Ethics Committee at the Technion Institute (Haifa, Israel) (Ethics number IL1481110). Author Contributions FF and RB-S designed the study and wrote the manuscript. RB-S performed the experiments and analyzed the data. MB and SG collected the plants and prepared the extract. NA and LS took part in the in vivo studies. All authors reviewed the draft manuscripts, read, and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank Dr. Sagie Schif-Zuck for the use of FACSCanto II (BD) equipment and the stuff of the animal house at the Technion Institute. References 1. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 201...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research