Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation
In conclusion, e-As4S4 holds great potential for an alternative therapeutics in the treatment of breast cancer, due to its unique function of correcting the aggressive microenvironment. Introduction Metastasis is the leading cause of breast cancer mortality, which has been one major challenge in clinical treatment (1). In particular, triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptors (ER), progesterone receptors (PR) and HER2 receptors, which is one of the most aggressive types of breast cancers, marked by high rates of relapse, visceral metastases and early death (2, 3). The treatment of TNBC is local therapy with surgery and/or radiotherapy followed by standard anthracycline and/or taxane-based systemic adjuvant treatment (3, 4). Despite an initial response to systemic chemotherapy, patients with TNBC often follow an aggressive course of progression and metastasis and develop multidrug resistance to conventional therapies (5). Besides, patients with TNBC are less sensitive to typical endocrine therapies due to lack of the receptors (6). Therefore, there is still an unmet need in the treatment of breast cancer, and the development of new therapeutics for preventing and treating metastasis for the management of TNBC patients is of great significance. Arsenic sulfide (As4S4, or termed as realgar) is a mineral drug that can be orally administrated and has shown a certain therapeutic effect in acute promyelocytic leukemia (APL) (7...
Weight-bearing CT scans can provide new insight into foot and ankle disorders and valuable information for surgical planning.Journal of the American Academy of Orthopaedic Surgeons
SUPPLEMENTS could be used to improve the health of your heart, as well as to protect against high blood pressure symptoms and signs. Add these cheap garlic capsules to your diet to lower your risk of heart problems, including heart attacks and heart disease.
This article summarizes the up-to-date information regarding the phytochemistry, pharmacology, processing, toxicity and safety of Rou Cong Rong to reveal its pharmacodynamic basis and potential therapeutic effects, which could be of great value for its use in future research. PMID: 32741910 [PubMed - in process]
Advice and information on how to look after your mental health and wellbeing during the coronavirus (COVID-19) outbreak. Update in this version (published 4th August 2020) - added translated documents in Arabic, Bengali, Chinese CN, Chinese HK, French, Gujarati, Polish, Portuguese, Punjabi and Urdu.
This is advice for parents and carers on looking after the mental health and wellbeing of children or young people during the coronavirus (COVID-19) outbreak. Update in this version (published 4th August 2020) - added translated documents in: Arabic, Bengali, Chinese CN, Chinese HK, French, Gujarati, Polish, Portuguese, Punjabi and Urdu.
Those suffering from cancer, heart conditions, strokes, diabetes and lung disease are among the worst affected by delays to their diagnosis and care, a survey of senior doctors reveals.
How does sustained virologic response from direct-acting antiviral and interferon-based treatments impact the risk of developing hepatocellular carcinoma?Journal of Viral Hepatitis
HOW TO live longer: Long life expectancy is something we would all like to strive for. According to studies, the timing of when you eat could be just as important as what you eat. Health experts advise a new way of eating which will help burn fat, improve memory, aid in a healthier heart, reduce the risk of disease and boost longevity.
The objective of this study was to report the incidence of alopecia arising in patients treated with vismodegib, assessing its characteristics, grade of severity, and time of onset.Skin Appendage Disord
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