Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation

In conclusion, e-As4S4 holds great potential for an alternative therapeutics in the treatment of breast cancer, due to its unique function of correcting the aggressive microenvironment. Introduction Metastasis is the leading cause of breast cancer mortality, which has been one major challenge in clinical treatment (1). In particular, triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptors (ER), progesterone receptors (PR) and HER2 receptors, which is one of the most aggressive types of breast cancers, marked by high rates of relapse, visceral metastases and early death (2, 3). The treatment of TNBC is local therapy with surgery and/or radiotherapy followed by standard anthracycline and/or taxane-based systemic adjuvant treatment (3, 4). Despite an initial response to systemic chemotherapy, patients with TNBC often follow an aggressive course of progression and metastasis and develop multidrug resistance to conventional therapies (5). Besides, patients with TNBC are less sensitive to typical endocrine therapies due to lack of the receptors (6). Therefore, there is still an unmet need in the treatment of breast cancer, and the development of new therapeutics for preventing and treating metastasis for the management of TNBC patients is of great significance. Arsenic sulfide (As4S4, or termed as realgar) is a mineral drug that can be orally administrated and has shown a certain therapeutic effect in acute promyelocytic leukemia (APL) (7...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: January 2020Source: Radiation Physics and Chemistry, Volume 166Author(s): E. Kavaz, S.R. Armoosh, U. Perişanoğlu, N. Ahmadi, M. OltuluAbstractThis work focused to survey the radiation shielding properties of cement paste samples doped without and with Cu 10% and brass 5, 10, 15, 20% wt. Molar volume of the cement samples was determined by the densities obtained with the Archimedes principle. Transmission measurements of the samples were achieved using an Ultra Ge detector at 81, 276, 302, 356, 383 keV photon energies emitted from the Ba-133 radioactive point source. The essential parameters; mass atte...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
In this study, effects of CDP-choline on the well known negative effects of Rapid Eye Movements (REM) sleep deprivation on learning and memory were investigated. Sleep deprivation was induced by placing adult male Wistar albino rats on 6.5 cm diameter platforms individually for 96 hours according to flower pot method. Learning and memory performances were evaluated using Morris Water Maze (MWM) test during the same period of time. Saline or CDP-choline (100 µmol/kg, 300 µmol/kg or 600 µmol/kg) was administered intraperitoneally 30 minutes prior to the onset of MWM experiments. On completion of behavioral ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 23 October 2019Source: Molecular and Cellular ProbesAuthor(s): Yi ChenAbstractCyclooxygenase-2 (COX-2) is an inducible enzyme that plays a key role in the inflammatory cascade through the generation of prostaglandins. Recent studies have found that COX-2 is closely related to the occurrence and development of tumors, angiogenesis and metastasis of tumors. Overexpressed COX-2 has become a predictive biomarker for progression of pre-malignant towards cancer in some tissues, which makes the detection of COX-2 of great value and clinical significance. This review highlights COX-2-specific flu...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 22 October 2019Source: Journal of Molecular StructureAuthor(s): Ali Keivanloo, Mahsa Fakharian, Saghi SepehriAbstractNew 1,2,3-triazoles based on 3-Substituted 2-thioquinoxalines were synthesized via a copper-catalyzed click reaction. The new 1,2,3-triazoles were screened for their in vitro antibacterial activities and were subjected to molecular docking studies. The starting materials included, 3-substituted-2-propargylthioquinoxalines were prepared from 2,3-dichloroquinoxaline, aliphatic amines, sodium sulfide, and propargyl bromide. The click of 2-propargythioquinoxalines with aryl azi...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02129A, CommunicationYouping Tian, Yi Gong, Xiao-Si Hu, Jin-Sheng Yu, Ying Zhou, Jian Zhou A highly efficient metal-free aldol-type reaction of various acetals or ketals with fluorinated silyl enol ethers catalysed by less than 1 mol% HClO4 (70% wt., aq.) is developed. This provides... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01967G, PaperYi He, Thomas Narmon, Danjun WU, Zhenghua Li, Luc Van Meervelt, Erik V Van der Eycken A rapid approach for the diversity-oriented synthesis of complex bridged polycyclic N-heterocycles from readily available starting materials in two operational steps has been developed. This strategy firstly introduces molecular diversity... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02165E, PaperDengke Li, Jian Lei A method for the synthesis of 2-thiolated benzimidazoles is described starting from thiols and 1-azido-2-isocyanoarenes. The isocyano group works as acceptor of various thio radicals, followed by denitrogenative annulation of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02138H, PaperChen Zhou, Chen Hu, Gang Hong, Yuchen He, Zhicong Tang, Limin Wang A highly efficient dehydrogenative reaction of a series of nucleophiles with 9-aryl-fluoren-9-ols has been realized by using only 2 mol % of Sc(OTf)3 as catalyst. The corresponding indole-containing 9,9-diarylfluorenes were... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB02079A, PaperAdam Forman, Roland Pfoh, Alexander Eddenden, P. Lynne Howell, Mark Nitz Mono-de-N-acetylated β-(1→6)-N-acetyl-D-glucosamine penta- and hepta-saccharides were obtained using a convergent synthesis. The site of de-N-acetylation drives the selectivity of hydrolysis by PgaB. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02065A, PaperLaurent El Kaim, Mahanandaiah Kurva, Mansour Dol é Kerim, Rocío Gámez-Montaño The Ugi reaction of 2-nitrobenzoic acid derivatives has been used for a Diversity Oriented Synthesis of complex isoindolinones via a SNAr reaction involving the peptidyl position. When the cyclization is... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
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