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Molecules, Vol. 28, Pages 2400: Bruton & rsquo;s Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials
Molecules, Vol. 28, Pages 2400: Bruton’s Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials Molecules doi: 10.3390/molecules28052400 Authors: Dariusz Rozkiewicz Justyna Magdalena Hermanowicz Iwona Kwiatkowska Anna Krupa Dariusz Pawlak In the last few decades, there has been a growing interest in Bruton’s tyrosine kinase (BTK) and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) signaling pathway and affects B-cell proliferation and differentiation. Evidence demonstrating the expression of BTK on t...
Source: Molecules - March 6, 2023 Category: Chemistry Authors: Dariusz Rozkiewicz Justyna Magdalena Hermanowicz Iwona Kwiatkowska Anna Krupa Dariusz Pawlak Tags: Review Source Type: research

Study of L-Asparaginase, Vincristine, and Dexamethasone Combined With Intensity-modulated Radiation Therapy in Early-Stage Nasal NK/T-Cell Lymphoma
Conclusion: In patients with early-stage nasal NKTCL, our LVD-IMRT regimen produced excellent, durable therapeutic benefit in most patients, with acceptable toxicity and no acute mortality.
Source: American Journal of Clinical Oncology - March 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

All Itching Is Not Benign; A Case of Refractory Hypereosinophilic Syndrome Treated with Off Label CD52 Inhibitor-Alemtuzumab
CONCLUSIONOur patient responded well to alemtuzumab, without any notable side effects. Therapy should be reserved due to early and late adverse affects but this agent has proved to be an effective treatment for HES in terms of both complete hematologic response and duration (Strati, P. et. al Clinical Lymphoma, Myeloma & Leukemia 2012). Moreover resistance is not seen, as patients with relapse were able to achieve a second remission. Data about efficacy and safety in the long-term remains lacking, but for treatment resistant and refractory HES, Alemtuzmab may be a suitable choice.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ansari, R., Osuna Salazar, E. N., Sarhill, N., Garcia, L. E., Hanley, J. Tags: 634. Myeloproliferative Syndromes: Clinical Source Type: research

Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency
ConclusionHSCT is curative in most DOCK8 deficient patients, confirming this approach as the treatment of choice. HSCT using a reduced toxicity regimen may offer the best chance for survival.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld's syndrome): A new flame
Publication date: Available online 12 October 2018Source: Autoimmunity ReviewsAuthor(s): Jan Willem Cohen TervaertAbstractIn the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias, myalgias, pyrexia, dry eyes and dry mouth. During the last few years, it has been postulated that these symptoms in patients with foreign body implants are due to a chronic inflammatory process and an adjuvant effect of the implanted biomaterial. Ultimately, these inflammatory reactions result i...
Source: Autoimmunity Reviews - October 12, 2018 Category: Allergy & Immunology Source Type: research

Incidence, clinical characteristics, and outcome of interstitial pneumonia in patients with lymphoma
In conclusion, IP is a life-threatening complication in lymphoma patients. Glucocorticoid therapy with continuous monitoring of chest radiographic changes may be a favourable strategy for treating IP. However, IP may recur, especially in patients re-treated with a similar chemotherapy regimen.
Source: Annals of Hematology - January 1, 2018 Category: Hematology Source Type: research

Silicone breast implants and autoimmune rheumatic diseases: myth or reality
Purpose of review: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. Recent findings: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may ’bleed’ and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system. Autoimmune/inflammatory syndrome by adjuvants (ASIA), allergies, autoimmun...
Source: Current Opinion in Rheumatology - June 2, 2017 Category: Rheumatology Tags: INFECTIONS AND ENVIRONMENTAL ASPECTS OF AUTOIMMUNITY: Edited by Yehuda Shoenfeld Source Type: research

New cancer drug can prevent reactions to common airborne allergens
(Northwestern University) A cancer drug for patients with certain types of leukemia and lymphoma can also prevent reactions to some of the most common airborne allergies, according to a recent Northwestern Medicine study. The promising data from this pilot study could have greater implications for adults with food allergies.
Source: EurekAlert! - Medicine and Health - May 22, 2017 Category: International Medicine & Public Health Source Type: news

Abstract PR03: Association of environmental risk factors, family history, and polygenic risk scores with chronic lymphocytic leukemia
Conclusions: We found evidence of independent effects among the genetic and non-genetic factors with risk of CLL. Among these factors, the PRS had the largest effect size. Although we did not observe any statistical interactions, larger sample sizes are warranted to fully evaluate these effects on risk of CLL. We are currently increasing our sample size through collaboration with other research groups. Final results will be presented in the meeting.This abstract is also being presented as Poster A06.Citation Format: Geffen Kleinstern, Dennis Robinson, Tim G. Call, Mark Liebow, Silvia de Sanjosé, Yolanda Benavente, J...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Kleinstern, G., Robinson, D., Call, T. G., Liebow, M., Sanjose, S. d., Benavente, Y., Cerhan, J. R., Slager, S. L. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

Glyphosate Chemophobia Grips Sonoma County: Sprayers Don Hazmat Suits, Respirators After Switch to 'Safer' Organic Weed Killers
If you've followed the often acrimonious debate over GMOs in foods, you've probably seen pictures of farmers walking through corn and soy fields bedecked in hazardous material suits and respirators. Why do they wear protective gear? According to anti-GMO activists, they are protecting themselves from glyphosate, a chemical often paired with GMOs that they claim is a cancer-causing herbicide. These people wearing hazmat suits are actually Greenpeace activists ripping up genetically engineered plants in the Philippines in 2011. That's ironic in a tragic way as the plants being uprooted are engineered with the natural soil-...
Source: Science - The Huffington Post - June 2, 2016 Category: Science Source Type: news

What Really Killed Glenn Frey
When Glenn Frey, a co-founder and driving force behind ’70s supergroup the Eagles, died on January 18, I wasn’t just saddened by the loss. I was deeply concerned about the manner of his death. News reports said Frey died from a combination of “complications” from rheumatoid arthritis (RA), one of the most debilitating chronic diseases. RA is an inflammatory autoimmune condition. It affects the entire body — particularly the joints. The body develops antibodies against its own joint tissues, breaking them down. A modern inflammatory diet, genetic factors and food allergies all play a role in developing RA. Enviro...
Source: Al Sears, MD Natural Remedies - February 16, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Men's Health arthritis inflammation vitamin D3 Vitamin K2 Source Type: news

Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge.
CONCLUSIONS: Physicians should be cautious about uncommon presentations of the viral infection and consider EBV as a causative agent when they encounter similar clinical pictures. PMID: 26802473 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - January 20, 2016 Category: Pediatrics Authors: Bolis V, Karadedos C, Chiotis I, Chaliasos N, Tsabouri S Tags: J Pediatr (Rio J) Source Type: research

“You Make the Call” — 86 Year old Female: Dizzy
  It is a beautiful September morning when the tones go off for a 91 year old female, “altered mental status”. “Guess breakfast will have to wait”, as you and your partner head towards the residence. As you enter the one level home, you are directed to a back bedroom where you find your patient lying in bed. She is alert and oriented, but her color seems pale. She seems uncomfortable. Her radial pulse is strong, and she is breathing normally. You ask what happened… ” I was sitting at the kitchen table having some tea when I got really dizzy. My friend helped me to bed, but it hasn&#...
Source: EMS 12-Lead - September 10, 2015 Category: Cardiology Authors: David Baumrind Tags: 12 lead ecg Cases ems-health-safety ems-topics patient-management 12-Lead ECG case study David Baumrind ems12lead.com Paramedic Source Type: research

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