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Cancer: Chronic Leukemia
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Total 284 results found since Jan 2013.
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research
Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions
Conclusions and Future Perspectives
It is now evident that NK/ILC family plays a pivotal role in the immune defenses. Recent studies in murine and human settings demonstrated that the expression of several inhibitory checkpoints, that may be detrimental in the tumor context, is not restricted to T lymphocytes, revealing an important, yet poorly appreciated, contribution of their expression on innate immune cells. Thus, in the recent years different immunotherapy approaches, based on the blockade of inhibitory NK cell receptors, have been developed in order to unleash NK cell cytotoxicity. This is particularly important in...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research
Leukocyte Heparanase: A Double-Edged Sword in Tumor Progression
Conclusions
This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity.
We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research
TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes
In conclusion, this study provides a systematic analysis of the expression of TRAIL-Rs in human primary B cells and of their capacity to signal and induce apoptosis. This dataset forms a basis to further study and understand the dysregulation of TRAIL-Rs and TRAIL expression observed in autoimmune diseases. Additionally, it will be important to foresee potential bystander immunomodulation when TRAIL-R agonists are used in cancer treatment.
Introduction
The homeostasis of humoral immunity requires a tight control of generation, survival, activation and maturation of B lymphocytes. Therefore, pro-survival and pro-apo...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research
Hepatic Natural Killer Cells: Organ-Specific Sentinels of Liver Immune Homeostasis and Physiopathology
Joanna Mikulak1,2, Elena Bruni1,2, Ferdinando Oriolo1,2, Clara Di Vito1 and Domenico Mavilio1,2*
1Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Milan, Italy
2Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy
The liver is considered a preferential tissue for NK cells residency. In humans, almost 50% of all intrahepatic lymphocytes are NK cells that are strongly imprinted in a liver-specific manner and show a broad spectrum of cellular heterogeneity. Hepatic NK (he-NK) cells play key roles in tuning liver immune response in b...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research
Successful Oral Desensitization with Dasatinib in Delayed Cutaneous Hypersensitivity Reactions
Dasatinib (Bristol-Myers Squibb) is a short-acting inhibitor of multiple tyrosine kinases which is used orally in treatment of chronic myeloid leukemia, Philadelphia-chromosome positive acute Lymphoblastic leukemia (ALL), solid tumors and systemic mastocytosis [1]. Despite acceptable safety profile of dasatinib, cutaneous adverse reactions including xerosis, keratosis pilaris, pruritus, maculopapular/exfoliative rashes, edema, alopecia may limit its use in crucial conditions [2]. In case of drug-related cutaneous rashes, the primary approach is withdrawal of the culprit agent and introduction of supportive treatment.
Source: Annals of Allergy, Asthma and Immunology - May 16, 2019 Category: Allergy & Immunology Authors: Betul Karaatmaca, Selin Aytac, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer Tags: Letters Source Type: research
Hemokinin ‐1 stimulates C‐C motif chemokine ligand 24 production in macrophages to enhance eosinophilic inflammation in nasal polyps
ConclusionEosinophil ‐derived HK‐1 induces CCL24 production from macrophages and therefore exaggerates eosinophilic inflammation in CRSwNP.
Source: International Forum of Allergy and Rhinology - September 22, 2019 Category: Allergy & Immunology Authors: Yi ‐Ke Deng,
Jin Ma,
Zhi‐Chao Wang,
Xiao‐Bo Long,
Cai‐Ling Chen,
Qi‐Miao Feng,
Xin‐Hao Zhang,
Ming Zeng,
Heng Wang,
Xiang Lu,
Zheng Liu Tags: ORIGINAL ARTICLE Source Type: research
M255 persistent hypogammaglobulinemia following obinutuzumab treatment for chronic lymphocytic leukemia
We report a patient who completed obinutuzumab treatment, a type 2 anti-CD20 monoclonal antibody, for chronic lymphocytic leukemia (CLL) with resulting symptomatic hypogammaglobulinemia.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: M. Hauk, B. McGoey, M. Michelis Source Type: research
M234 management of chronic immune thrombocytopenia in a child with germline ikaros mutation
IKAROS, a transcription factor encoded by IKZF1, is crucial for B cell development. Germline IKZF1 mutations may manifest with impaired B cell function, autoimmunity, and B cell precursor acute lymphoblastic leukemia (BCP-ALL).
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: D. Groth, M. Lakkaraja, J. Ferreira, E. Feuille, J. Bassetti, S. Kaicker Source Type: research
A250 humoral immunodeficiency in patients with chronic lymphocytic leukemia
Patients with chronic lymphocytic leukemia (CLL) are at increased risk of infections as compared to age matched controls, and infections are a major cause of morbidity and mortality. Although hypogammaglobinemia occurs with CLL, there is minimal data regarding vaccine responses in these patients. We characterized immunoglobulin (Ig) levels and vaccine responses in patients with CLL.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: S. Mustafa, S. Jamshed, A. Ramsey Tags: Clinical Immunology, Immunodeficiency Source Type: research
Three-Drug Combo Promising Against High-Risk CLL Three-Drug Combo Promising Against High-Risk CLL
The combination of obinutuzumab, ibrutinib, and venetoclax was associated with a high complete response rate in patients with high-risk chronic lymphocytic leukemia, a phase 2 trial finds.Medscape Medical News
Source: Medscape Allergy Headlines - June 15, 2020 Category: Allergy & Immunology Tags: Hematology-Oncology News Alert Source Type: news
Skin testing with bendamustine: what concentration should be used?
We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls ...
Source: Allergy, Asthma and Clinical Immunology - July 30, 2020 Category: Allergy & Immunology Authors: Laura Malinauskiene, Kestutis Cerniauskas, Kotryna Linauskiene, Linas Griguola, Anzelika Chomiciene and Audra Blaziene Tags: Letter to the editor Source Type: research
Inhibition of VEGF and MMP-9 production by Pregabalin in human immunocompetent cells in vitro
Conclusion: Pregabalin down-regulates VEGF and MMP-9 in U937 and Molt-4 cells. As VEGF and MMP-9 have an important role in inflammation, anti-inflammatory properties of pregabalin may be partly due to its inhibitory effects on MMP-9/VEGF expression. So pregabalin along with its positive effects in neuropathic disorders can be useful in planning of therapeutic ways for airway inflammatory diseases such as COPD in which VEGF and MMP-9 are highly-expressed.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Hajighasemi, F., Darouni, L. Tags: Allergy and immunology Source Type: research
M024 bosutinib-induced steven johnson syndrome and evidenced tolerance to a structurally dissimilar tyrosine kinase inhibitor
Bosutinib is a BCR-ABL tyrosine kinase inhibitor (TKI) used for the treatment of chronic myeloid leukemia (CML). Patients on TKIs may develop severe cutaneous adverse reactions (SCARs).
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: K. Avila, I. Carrillo-Martin, L. Bojanini, A. Gonzalez-Estrada Source Type: research
The basophil: from control of immunity to control of leukemias
Ann Pharm Fr. 2021 May 26:S0003-4509(21)00074-2. doi: 10.1016/j.pharma.2021.05.005. Online ahead of print.ABSTRACTThe basophils, first described by Paul Ehlrich in 1879, are rare circulating cells, representing approximately 0.01 to 0.3 % of the blood leukocytes. Until recently, these cells have been neglected because of their minority status among immune cells and because they show some similarities to mast cells residing in tissues. However, basophils and mast cells are now recognized as distinct cell lines and it appears that basophils have important and non-redundant functions, distinct from those of mast cells. On the...
Source: Annales Pharmaceutiques Francaises - May 29, 2021 Category: Drugs & Pharmacology Authors: Michel Arock Source Type: research
