Successful Oral Desensitization with Dasatinib in Delayed Cutaneous Hypersensitivity Reactions

Dasatinib (Bristol-Myers Squibb) is a short-acting inhibitor of multiple tyrosine kinases which is used orally in treatment of chronic myeloid leukemia, Philadelphia-chromosome positive acute Lymphoblastic leukemia (ALL), solid tumors and systemic mastocytosis [1]. Despite acceptable safety profile of dasatinib, cutaneous adverse reactions including xerosis, keratosis pilaris, pruritus, maculopapular/exfoliative rashes, edema, alopecia may limit its use in crucial conditions [2]. In case of drug-related cutaneous rashes, the primary approach is withdrawal of the culprit agent and introduction of supportive treatment.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research

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Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news
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Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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