Filtered By:
Cancer: Chronic Leukemia

This page shows you your search results in order of relevance. This is page number 16.

Order by Relevance | Date

Total 284 results found since Jan 2013.

Transient neutropenia following intravenous alemtuzumab treatment
Alemtuzumab is a humanised monoclonal antibody approved for treatment of active relapsing remitting multiple sclerosis (RRMS). It targets CD-52 glycoprotein on the cell surface of mature lymphocytes, resulting in their destruction, but is thought to leave polymorphonuclear cells unaffected. A 17 year old female with aggressive RRMS completed her first alemtuzumab course. Four weeks post-infusion monitoring bloods, identified neutropenia of 0.6, reaching a nadir of 0.4 in 3 days. Haematologist advised hospital admission with G-CSF treatment. We opted for home isolation; close phone call monitoring by specialist nurse. By we...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Salam, S., Dunbar, D., Jackson, F., Lavin, T., Pace, A., Mihalova, T. Tags: Immunology (including allergy), Multiple sclerosis ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Cll, a rare but treatable cause of longitudinally extensive myelitis
A 65-year-old lady presented with a 1-year history of progressive sensory and motor symptoms in the the legs, back pain, pruritus and night sweats. Neurological examination of the cranial nerves and upper limbs was unremarkable. Lower limb examination revealed mild bilateral spastic paraparesis. Cervical, axillary and inguinal lymphadenopathy was noted. Bloods showed only a mild lymphopenia. MRI revealed symmetrically diffuse nodular enhancement in the brain and longitudinally extensive transverse myelitis in the cervical and thoracic spine with leptomeningeal enhancement. CSF analysis showed a protein of 1888 mg/L, W...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Ahmed, W., Coe, J., Carroll, L., Vundavalli, S., Chevassut, T., Saha, R. Tags: Immunology (including allergy), Cranial nerves, Infection (neurology), Multiple sclerosis, Pain (neurology), Spinal cord, Radiology, Surgical diagnostic tests, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A  potential mechanism for tobacco smoke–associated atopic dermatitis
Exposure to environmental chemicals can contribute to the development or exacerbation of atopic dermatitis (AD). Benzene is one of the chemicals previously been implicated in the etiology  of AD.1 Albeit a ubiquitous environmental chemical, nonoccupational exposure to benzene mainly results from active or passive tobacco smoke exposure in homes or public places. Exposure to benzene has been shown to exert diverse effects on blood cells, in particular on lymphocytes. Although chronic exposure to high levels of benzene may cause leukemia and probably other lymphohematopoietic cancers, already low levels of benzene have been...
Source: Journal of Allergy and Clinical Immunology - March 5, 2017 Category: Allergy & Immunology Authors: Marcus Winter, Loreen Th ürmann, Zuguang Gu, Gerrit Schüürmann, Gunda Herberth, Denise Hinz, Martin von Bergen, Hauke Harms, Sven Olek, Stefan Röder, Michael Borte, Roland Eils, Irina Lehmann, Saskia Trump Tags: Letter to the Editor Source Type: research

Imatinib mesylate- and dasatinib-induced eosinophilia in a patient with chronic myelocytic leukemia
We present a case of a woman being treated for chronic myelocytic leukemia (CML) who developed eosinophilia without systemic involvement from imatinib mesylate (imatinib) confirmed by rechallenge with imatinib followed by eosinophilia recrudescence from dasatinib.
Source: Annals of Allergy, Asthma and Immunology - May 9, 2017 Category: Allergy & Immunology Authors: Kris McGrath, Brady Stein, Lindsey Kalhagen, Lauren Leighton Tags: Letter Source Type: research

P037 Exaggerated delayed hypersensitivity response to insect bites in a patient with chronic lymphocytic leukemia
Exaggerated delayed hypersensitivity responses to insect bites have been associated with malignancies. This case demonstrates the association between delayed hypersensitivity responses to mosquito bites and the recurrence of chronic lymphocytic leukemia (CLL).
Source: Annals of Allergy, Asthma and Immunology - October 27, 2017 Category: Allergy & Immunology Authors: Y. Mo, M. Tobin, A. Trivedi Source Type: research

Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases
AbstractEpidemiological studies have shown that inflammation plays a critical role in the development and progression of various chronic diseases, including cancers, neurological diseases, hepatic fibrosis, diabetic retinopathy, and vascular diseases. Decursin and decursinol angelate (DA) are pyranocoumarin compounds obtained from the roots ofAngelica gigas. Several studies have described the anti-inflammatory effects of decursin and DA. Decursin and DA have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and...
Source: Inflammation Research - November 13, 2017 Category: Research Source Type: research

Management of hypogammaglobulinemia and recurrent infections in a chronic lymphocytic leukemia patient receiving ibrutinib
Chronic lymphocytic leukemia (CLL) is a chronic lymphoproliferative disorder characterized by the progressive accumulation of monoclonal and functionally incompetent lymphocytes; it also is the most common adult leukemia in Western countries.1 In CLL, hypogammaglobulinemia is the predominant inherent immune defect and is often further exacerbated by immunosuppressive treatment.2 Nevertheless, neither antibiotic prophylaxis nor prophylactic immunoglobulin (Ig) replacement therapy (IRT) is routinely recommended for CLL.
Source: Annals of Allergy, Asthma and Immunology - November 23, 2017 Category: Allergy & Immunology Authors: Fonda Jiang, Prashant Verma Tags: Letter Source Type: research

Cryptotanshinone inhibits IgE ‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells.
Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells. Mol Med Rep. 2018 May 22;: Authors: Buyanravjikh S, Han S, Lee S, Jeong AL, Ka HI, Park JY, Boldbaatar A, Lim JS, Lee MS, Yang Y Abstract Atopic dermatitis (AD) is a type of chronic skin inflammation and one of the most common relapsing allergic diseases, which presents with a severe rash and itchy skin lesions. The pathogenesis of AD is primarily associated with hyper‑activated mast cells, which makes them an effective treatment target. Afte...
Source: Molecular Medicine Reports - June 2, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Resolution of Eosinophilia and Elevated Immunoglobulin E with Ibrutinib for Chronic Lymphocytic Leukemia
We describe a case of eosinophil ia and elevated IgE in a 61-year-old gentleman who was subsequently diagnosed with B-cell chronic lymphocytic leukemia (B-CLL). His eosinophilia and immunoglobulin E (IgE) levels declined significantly after initiating ibrutinib therapy for B-CLL.
Source: Annals of Allergy, Asthma and Immunology - July 15, 2018 Category: Allergy & Immunology Authors: Kaoru Harada, Joel P. Brook, Francis M. Lobo Tags: Letters Source Type: research

Advances in site-specific gene editing for primary immune deficiencies
Purpose of review Conventional gene therapy has been a successful, curative treatment modality for many primary immune deficiencies with significant improvements in the last decade. However, the risk of leukemic transformation with viral-mediated gene addition still remains, and unregulated gene addition is not an option for certain diseases in which the target gene is closely controlled. The recent bloom in genome modification platforms has created the opportunity to site-specifically correct mutated DNA base pairs or insert a corrective cDNA minigene while maintaining gene expression under control of endogenous regulat...
Source: Current Opinion in Allergy and Clinical Immunology - November 2, 2018 Category: Allergy & Immunology Tags: PRIMARY IMMUNE DEFICIENCY DISEASE: Edited by Stephen Jolles and M. Teresa (Maite) de la Morena Source Type: research

Risk of Invasive Fungal Infections in Patients with High-Risk MDS and AML Receiving Hypomethylating Agents
ConclusionIFI occurred in 9.6% of patients treated with HMA, but was observed in 20.4% of those who were neutropenic on C1D1 of HMA. Another potential risk factor identified was t-MDS versus de novo MDS. Prospective evaluation of mold-active antifungal prophylaxis in patients with MDS or AML who are neutropenic at the start of HMA therapy is warranted.DisclosuresFrey: Novartis: Consultancy; Servier Consultancy: Consultancy. Perl: Arog: Consultancy; NewLink Genetics: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees; Astellas: Con...
Source: Blood - November 21, 2018 Category: Hematology Authors: Kim, G. Y., Burns, J., Freyer, C. W., Hamilton, K., Schuster, M., Frey, N. V., Hexner, E. O., Mangan, J. K., Martin, M. E., McCurdy, S. R., Perl, A. E., Porter, D. L., Luger, S., Loren, A. W. Tags: 637. Myelodysplastic Syndromes-Clinical Studies Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer
Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review. Introduction Chimeric antigen receptors and engineered T cell receptors (based on previously identified high affinity T cell receptors) function by redirecting T cells to a predefined tumor-specific (or tumor-associated) target. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors ...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Incidence and Outcome of Invasive Fungal Diseases in Children With Hematological Malignancies and/or Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Multicenter Study
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research