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Sleep Apnea and 20-Year Follow-Up for All-Cause Mortality, Stroke, and Cancer Incidence and Mortality in the Busselton Health Study Cohort
Conclusions:Moderate-to-severe sleep apnea is independently associated with a large increased risk of all-cause mortality, incident stroke, and cancer incidence and mortality in this community-based sample.Commentary:A commentary on this article appears in this issue on page 363.Citation:Marshall NS; Wong KK; Cullen SR; Knuiman MW; Grunstein RR. Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton health study cohort. J Clin Sleep Med 2014;10(4):355-362.
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2014 Category: Sleep Medicine Source Type: research

Severe sleep apnea linked to increased risk of stroke, cancer, death
Moderate to severe obstructive sleep apnea is independently associated with an increased risk of stroke, cancer and death. Results of the 20-year follow-up study show that people with moderate to severe obstructive sleep apnea were four times more likely to die (hazard ratio = 4.2), nearly four times more likely to have a stroke (HR = 3.7), three times more likely to die from cancer (HR = 3.4), and 2.5 times more likely to develop cancer. Results were adjusted for potential confounding factors such as body mass index, smoking status, total cholesterol and blood pressure.
Source: ScienceDaily Headlines - April 14, 2014 Category: Science Source Type: news

Study links severe sleep apnea to increased risk of stroke, cancer and death
(American Academy of Sleep Medicine) A new study shows that moderate to severe obstructive sleep apnea is independently associated with an increased risk of stroke, cancer and death.
Source: EurekAlert! - Cancer - April 14, 2014 Category: Cancer & Oncology Source Type: news

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD. Ethics Statement All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

EPMA-World Congress 2015
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of ...
Source: EPMA Journal - May 8, 2016 Category: Global & Universal Source Type: research

Pharmacotherapy of obesity: clinical treatments and considerations.
Abstract Obesity is a world-wide epidemic associated with significant morbidity and mortality which costs billions of dollars per year. The associated related conditions are many and include heart disease, stroke, type II diabetes mellitus, sleep apnea and certain types of cancer. Given that it is a multifactorial problem, the treatments must also address the numerous causes associated with the development of obesity. The neurohormonal regulation of feeding and energy is a complex system often necessitating modification through more than 1 pathway to achieve weight loss. Therefore, in addition to lifestyle changes...
Source: The American Journal of the Medical Sciences - April 1, 2013 Category: Journals (General) Authors: Holes-Lewis KA, Malcolm R, O'Neil PM Tags: Am J Med Sci Source Type: research

Obesity Perception by Health Care Providers—Can it Influence Patient Safety?
The Centers for Disease Control (CDC) defines obesity as a body mass index (BMI) of 30.0 or greater. According to the CDC, 36% of US adults are obese as well as 17% of US children and adolescents. Among ethnic groups, the highest percentages of obesity affect non-Hispanic blacks (49.5%). The prevalence of obesity among the US young has tripled since 1980. Obesity is known to be associated with multiple health conditions such as diabetes and heart disease. As such, its impact on health care delivery and outcomes can be very influential. Although many people appreciate the relationship of obesity to both diabetes and heart d...
Source: Journal of PeriAnesthesia Nursing - May 29, 2013 Category: Nursing Authors: Jacqueline M. Ross Tags: Patient Safety Source Type: research

Adipose tissue dysfunction contributes to obesity related metabolic diseases
Obesity significantly increases the risk of developing type 2 diabetes, hypertension, coronary heart disease, stroke, fatty liver disease, dementia, obstructive sleep apnea and several types of cancer. Adipocyte and adipose tissue dysfunction represent primary defects in obesity and may link obesity to metabolic and cardiovascular diseases. Adipose tissue (AT) dysfunction manifests by a proinflammatory adipokine secretion pattern that mediate auto/paracrine and endocrine communication and by inflammatory cell infiltration, particularly in intra-abdominal fat. Impaired AT function is caused by the interaction of genetic, be...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - April 1, 2013 Category: Endocrinology Authors: Matthias Blüher Tags: Section 2: Health Impacts of Obesity Source Type: research

Obesity paradox in peripheral vascular disease
To prevent cardiovascular diseases, it is essential to control risk factors, among which obesity is a world-wide issue that we are currently facing . Obesity was found to be an independent cardiovascular risk factor by the Framingham Heart study, in which the participants were followed up over 26 years; a higher risk was observed in both men and women whose body weights increased after the young adult years . It has been shown that obesity, particularly visceral obesity, is closely related not only to classical cardiovascular risk factors such as dyslipidemia, diabetes, and hypertension, but also to insulin resistance, abn...
Source: Atherosclerosis - June 3, 2013 Category: Cardiology Authors: Johji Kato Tags: Invited Commentaries Source Type: research

Adiponectin as a routine clinical biomarker.
Abstract Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 μg/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), slee...
Source: Clin Med Res - January 1, 2014 Category: Research Authors: Kishida K, Funahashi T, Shimomura I Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Cardiovascular effects of current and future anti-obesity drugs.
Abstract The prevalence of obesity increases and is associated with increases in co-morbidities e.g. type 2 diabetes, hyperlipidemia, hypertension, obstructive sleep apnea, heart disease, stroke, asthma, several forms of cancer, depression, and may result in reduction of expected remaining lifespan. We have reviewed the adverse effects on the cardiovascular system of anti-obesity drugs now retracted from the market as well as the cardiovascular profile of current drugs and potential pathways which are considered for treatment of obesity. Fenfluramine, and sibutramine were withdrawn due to increased cardiovascular ...
Source: Current Vascular Pharmacology - May 24, 2014 Category: Drugs & Pharmacology Authors: Comerma-Steffensen S, Grann M, Andersen CU, Rungby J, Simonsen U Tags: Curr Vasc Pharmacol Source Type: research

Natural anti-obesity agents
Publication date: Available online 14 June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Gamal A. Mohamed , Sabrin R.M. Ibrahim , Ehab S. Elkhayat , Riham Salah El Dine Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and environmental factors, which favors a chronic positive energy balance, and leads to increased body fat mass. The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. Indeed, obesity facilitates the development of metabolic disorders such as diabetes, hy...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Amy Poehler Struggles With Sleep Just Like The Rest Of Us
You'd think the juggling act of raising two young sons, producing, acting and sometimes directing the final season of "Parks and Recreation," hosting the 2013 and 2014 Golden Globes and maintaining her besties status with Seth Meyers and Tiny Fey would be tiring enough. But actress Amy Poehler doesn't curl into bed at night and fall asleep immediately out of pure exhaustion. In her recently released memoir Yes Please, Poehler hilariously chronicles major events in her life with wisdom and ease -- including her early Chicago improv days, kicking ass as a waitress, getting hired for "Saturday Night Live" at age 30, her marr...
Source: Healthy Living - The Huffington Post - November 18, 2014 Category: Consumer Health News Source Type: news

Erectile dysfunction and obstructive sleep apnea: From mechanisms to a distinct phenotype and combined therapeutic strategies
Non-communicable Diseases (NCDs), mainly cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases, are responsible for two-thirds of the 57 million annual deaths worldwide. Tobacco smoking, physical inactivity, unhealthy diets and the resulting obesity are established risk factors for many chronic diseases (Figure 1). Management of the rise in the prevalence of chronic diseases is a major challenge facing governments and health-care systems worldwide. As these disorders are now the leading causes of death and hospitalizations, health authorities assign high priority to heart disease, diabetes, sleep apne...
Source: Sleep Medicine Reviews - December 27, 2014 Category: Sleep Medicine Authors: Jean-Louis Pépin, Renaud Tamisier, Diane Godin-Ribuot, Patrick Lévy Tags: Guest editorial Source Type: research

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