Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt

In this study, we used HUT as the means to provide an all-encompassing assessment of cardiac and/or peripheral autonomic function in normal controls, SCD subjects and non-SCD subjects with chronic anemia. We hypothesized that by identifying different categories of HUT response among these subjects, we would be able to isolate the autonomic phenotypes that might place SCD subjects at increased risk for microvascular occlusion and VOC. We then employed the causal modeling approach, which utilizes signal analysis and system identification techniques, to probe and disentangle the functional mechanisms involved in the cardiovascular control system (Xiao et al., 2005; Batzel et al., 2009; Khoo, 2018). These advanced analyses provided additional clues into which mechanisms were responsible for predisposing SCD subjects to having different HUT response phenotypes, thereby enabling us to identify the source of the autonomic abnormality in SCD most likely to increase risk of VOC. Materials and Methods Participants All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The study protocol was approved by the Committee on Clinical Investigations, the institutional review board (IRB) of CHLA. Participants, who were at least 13 years old, were selected from ethnically matched family members, SCD subjects and other patients followed in the red cell and hemoglobinopathy program at CHLA. Exclusion criteria were any known acute or chronic illnesses including cardiova...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
European Journal of Human Genetics, Published online: 06 December 2021; doi:10.1038/s41431-021-01011-830 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Former presidents and political leaders recalled Mr. Dole’s dignity, sense of humor and lifetime commitment to public service. #bobdole #presidents #obama
Source: Reuters: Health - Category: Consumer Health News Source Type: news
NEW BRUNSWICK, N.J., DECEMBER 5, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced preliminary results from an independent study, including a subset of participants from the Janssen-sponsored COV2008 study, conducted by Dan Barouch, M.D., Ph.D., et al. of Beth Israel Deaconess Medical Center (BIDMC), which showed that a booster shot of the Johnson &Johnson COVID-19 vaccine (Ad26.COV2.S), administered at six months after a two-dose primary regimen of BNT162b2, increased both antibody and T-cell responses. These results demonstrate the potential benefits of heterologous boosting (mix-and-match)....
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
A STROKE is a medical emergency and urgent treatment is essential. There are fortunately several ways to reduce your risk.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Experts said it is likely that there is already community spread of the variant in the United States.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus Omicron Variant Coronavirus (2019-nCoV) Vaccination and Immunization Collins, Francis S Fauci, Anthony S Van Kerkhove, Maria Walensky, Rochelle United States South Africa Disease Rates Source Type: news
In my last post I described the “4 P” model (sometimes called the 5P!) of formulation for pain. In today’s post I want to talk about an integrated approach for a team. Teamwork in pain management is an enormous thing – IASP (International Association for the Study of Pain) endorses multidisciplinary (I prefer interprofessional) teamwork but gives little information on how teams best work together. In fact, research exploring teamwork processes in pain management is remarkably absent, even though there’s considerable research elsewhere in healthcare showing that effective teamwork is quite ...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Assessment Chronic pain Clinical reasoning Interdisciplinary teams Professional topics Psychology Research Science in practice biopsychosocial case formulation Health healthcare pain management teamskills teamwork Source Type: blogs
STOMACH cancer can often go undetected. Early symptoms of stomach cancer can be like symptoms of common stomach conditions.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
He’ll take on incumbent Brian Kemp, who has been repeatedly attacked by the former president. #davidperdue #briankemp
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Bob Dole was just 21 years old when he suffered the injuries that would change his life. In April 1945, while stationed in Italy during WWII, the young soldier was struck by enemy fire. As a result of his wounds, Dole was permanently left without feeling in his right hand and arm, which measured more than two inches shorter than his left after reparative surgeries; part of his left hand was also left numb. Dole, who died on Sunday at the age of 98, would live with and be shaped by the aftermath of those injuries in the years that followed, including the 30 he spent as a U.S. senator from Kansas. [time-brightcove not-tgx=&r...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized remembrance Second click Source Type: news
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