Notes from the 2023 Age-Related Disease Therapeutics Summit
The former Longevity Therapeutics conference series was renamed to the Age-Related Disease Therapeutics Summit and held its fifth event recently in San Francisco. It was a smaller meeting than in past years, perhaps a result of the recent downturn in the global financial and investment environment. Few investors were present. Nonetheless, one can usually learn something interesting from the presenting biotech founders and executives. I took a few notes while I was there to present on progress at Repair Biotechnologies, and they follow in the order of the conference program.
Birget Schilling from the Buck Institute f...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Humira Biosimilar Gross-to-Net Pricing Bubble Was Preceded by the Same Pricing Bubble Burst for Insulin Just Months Ago
Today ' s post is not about diabetes per se, although there IS a diabetes connection. But this morning, the big news was that a biosimilar of Abbvie ' s blockbuster anti-inflammatory biologic Humira will be sold byMark Cuban Cost Plus Drug Company (see the press release athttps://www.globenewswire.com/news-release/2023/06/01/2680351/33333/en/Mark-Cuban-Cost-Plus-Drug-Company-joins-forces-with-Coherus-to-make-YUSIMRY-a-HUMIRA-biosimilar-available-to-patients.html for more) at what amounts to an 85% discount to the innovator drug. Mark Cuban Cost Plus Drug Company announced the Humira biosimilar on social media today. See th...
Source: Scott's Web Log - June 1, 2023 Category: Endocrinology Tags: 2023 Abbvie Biosimilar drug discounts gross-to-net bubble Humira insulin Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Excess Visceral Fat Generates Inflammatory Signaling that Harms Joint Health
In conclusion, these findings demonstrate the significance of obesity in changing the inflammatory landscape of synovial fibroblasts in both load bearing and non-load bearing joints.
Link: https://doi.org/10.1002/ctm2.1232 (Source: Fight Aging!)
Source: Fight Aging! - April 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Neuroimmune Modulation for Inflammatory Disease: Interview with Dr. Simhambhatla, President and CEO of SetPoint Medical
SetPoint Medical, a medtech company based in California, is developing a neuromodulatory device that is intended to treat rheumatoid arthritis. The overlap between the nervous and immune systems is increasingly appreciated, and this technology aims to capitalize on this to create a new treatment for inflammatory disease.
The neuromodulation device is intended to be implanted on the left cervical vagus nerve in an outpatient procedure. It stimulates the nerve with electrical pulses. The idea is that this can act to calm inflammatory processes that contribute to rheumatoid arthritis, without the drawbacks of immunosuppres...
Source: Medgadget - February 28, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Neurology autoimmune immunology SetPointMed Source Type: blogs
A teenager with chest pain, a troponin below the limit of detection, and " benign early repolarization "
Sent by anonymous, written by Pendell MeyersA male in his teens presented with complaints of chest discomfort and dyspnea beginning while exercising but without obvious injury. He immediately stopped exercising and symptoms started to improve. Later that evening he felt recurrent central chest discomfort, shortness of breath, and vomited. Symptoms have been constant since this second episode, and are still present on arrival, which seems to have been less than 1 to 2 hours from onset of symptoms. No similar symptoms in the past. No prior exertional complaints of chest pain, dizziness, lightheadedness, or undue shortness of...
Source: Dr. Smith's ECG Blog - January 9, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
On making things easier … Occupational therapists and ‘ compensatory ’ approaches
If there is one part of occupational therapy practice that gets more of my middle-aged grumpiness than any other, it’s occupational therapists using compensatory approaches for managing pain. And like anything, it’s complicated and nuanced. So here’s my attempt to work my way through the quagmire.
Compensatory approaches consist of a whole range of interventions that aim to “make up for” a deficit in a person’s occupational performance (see Nicholson & Hayward (2022) for a discussion of compensatory approaches in “functional neurological disorder”). The rationale for c...
Source: HealthSkills Weblog - December 4, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping Skills Coping strategies Occupational therapy Pain conditions Professional topics Research Science in practice compensatory strategies pain management Therapeutic approaches Source Type: blogs
Why adopt a lifestyle pyramid for rheumatoid arthritis?
Rheumatoid arthritis is a common autoimmune disease affecting approximately 1.5 million people only in the United States. The most common symptoms that will bring patients to the doctor are: pain swelling and stiffness in multiple joints. most of the time, in a bilateral and symmetric pattern Unfortunately, rheumatoid arthritis is not only a disease of
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Why adopt a lifestyle pyramid for rheumatoid arthritis? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 2, 2022 Category: General Medicine Authors: Diana M. Girnita, MD, PhD Tags: Conditions Rheumatology Source Type: blogs
Weekly Overseas Health IT Links – 29th October, 2022.
This report presents CDC findings on telehealth use trends in 2021. It includes data from the National Health Interview Survey, a nationally representative household survey conducted throughout the year by the National Center for Health Statistics. -----https://www.usnews.com/news/health-news/articles/2022-10-13/women-older-adults-more-likely-to-use-telemedicine-in-2021Who Used Telemedicine in 2021?New data shows which groups have been most likely to use a health care option popular during the pandemic.By Christopher WolfOct. 13, 2022, at 12:01 a.m.More than 1 in 3 adults used telemedicine in the past year in 2021, ac...
Source: Australian Health Information Technology - October 29, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Does Surviving The Plague Mean You Will Eventually Contract An Autoimmune Disease?
BY MIKE MAGEE
This Fall, I am teaching a 4-week course on “How Epidemics Have Shaped Our World” at the President’s College at the University of Hartford. It is, of course a timely topic, but also personally unnerving as we complete a third year under the shadow of Covid-19.
Where does one begin on a topic such as this? Yale historian, Frank M. Snowden, in his book “Epidemics and Society: From the Black Death to the Present”, made his intentions obvious. He would begin with the plaque. Why? His answer, “The word ‘plague’ will always be synonymous with ‘terror’”, and especially references:
...
Source: The Health Care Blog - October 26, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Autoimmune. Disease Mike Magee Plague Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Overseas Health IT Links – 15th October, 2022.
This article uses the one that divides providers into groups depending on the life cycle stage the clinic is at the given moment. According to this classification, medical providers fall into three groups:BeginnersGrowing clinicsWell-established providersHealth care providers are business entities, so their life cycle, like that of any business, consists of the early stage or launch, growth and maturity. At each stage, providers have different priorities and goals, and the choice of medical software solutions should be made accordingly.Medical software for beginnersThe launch phase can be tough. At this stage, the profits ...
Source: Australian Health Information Technology - October 15, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Mitochondrial Stress Provokes Inflammation via Fragments of Mitochondrial DNA
A large body of evidence links mitochondrial dysfunction with chronic inflammation. These are both features of aging, but it appears that dysfunctional, stressed mitochondria are a meaningful cause of inflammatory signaling. Mitochondria can generate molecular fragments, such as pieces of mitochondrial DNA, that are recognized as potentially threatening by the innate immune system. These damage-associated molecular patterns are present in much greater amounts in old tissues, and the immune system reacts to them to produce lasting, unresolved inflammation, harmful to tissue function rather than protective.
In today's...
Source: Fight Aging! - October 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How is thyroid linked to heart disease? Cardiology Basics
Disorders of thyroid gland can cause heart disease in multiple ways. Heart disease can occur with both hypothyroidism and hyperthyroidism. In hyperthyroidism, heart rate increases and there is a hyperdynamic circulatory state which can lead to high output cardiac failure. Unlike in the usual congestive heart failure in which the extremities are cold due to vasoconstriction, in heart failure due to hyperthyroidism, the extremities are warm. Instead of a low volume pulse in usual heart failure, thyrotoxic heart failure has a high volume pulse.
Another important cardiac problem in hyperthyroidism is atrial fibrillation with ...
Source: Cardiophile MD - October 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Focus on the rheumatoid arthritis patient, not on their disease
Medical school, residency, and fellowship taught me pathophysiology, diagnosis, and the most advanced treatments for autoimmune diseases like rheumatoid arthritis. As an attending physician, seeing my own patients, I noticed that targeted therapy is not able to control the disease in all patients with rheumatoid arthritis. The results varied. I could not stop asking myself,
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Focus on the rheumatoid arthritis patient, not on their disease originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 16, 2022 Category: General Medicine Authors: Diana M. Girnita, MD, PhD Tags: Conditions Rheumatology Source Type: blogs
