Disheartening result for cyclosporine A in nonshockable cardiac arrest
Administering cyclosporine A at the time of resuscitation of patients with nonshockable out-of-hospital cardiac arrest does not reduce the likelihood of subsequent multiple organ failure, shows the results of the CYRUS trial. (Source: MedWire News)
Source: MedWire News - July 15, 2016 Category: Consumer Health News Tags: Cardiology Source Type: news
Persian Gulf War Veterans Still Suffering Serious Health Problems
This year marks the 25th anniversary of the Persian Gulf War.
It was fought in late 1990 through early 1991 by a U.S.-led coalition of 34 countries against Iraq in response to Saddam Hussein's invasion of Kuwait.
It also was the first U.S. war to be waged after the advent of the 24-hour cable television news cycle.
The conflict was accompanied by memorably intense and round-the-clock coverage on CNN.
But there've been few recognitions of the war's 25-year milestone on the cable news networks, let alone in broadcast or print media.
For David Winnett, a Gulf War combat veteran who climbed the ranks from private to capta...
Source: Healthy Living - The Huffington Post - June 21, 2016 Category: Consumer Health News Source Type: news
Three decades beat as one: 30 years of heart transplants
Tina Medina and her son Luke
Tina Medina was not a sickly child, yet she grew up knowing something was physically wrong.
She had difficulty keeping up with the other kids in her sixth-grade class and couldn’t run without becoming breathless. Local physicians near her home in Moriah, New York, shrugged it off as asthma — until Tina’s heart stopped twice during a routine appendectomy. “I was told I had a severe heart condition and needed to see a cardiologist right away,” she says.
At 15, Tina was diagnosed with restrictive cardiomyopathy, a rare type of cardiomyopathy that causes the heart muscle to become stiff,...
Source: Thrive, Children's Hospital Boston - June 13, 2016 Category: Pediatrics Authors: Emily Williams Tags: Diseases & Conditions Our Patients’ Stories Research and Innovation cardiac surgery cardiomyopathy congential heart defect Department of Cardiac Surgery Dr. Elizabeth Blume Dr. John Mayer ECMO Heart Center heart transplant Heart Source Type: news
Allergan’s Oculeve on track for FDA submission this year
Allergan (NYSE:AGN) said today that it’s on track for an FDA submission this year for the Oculeve nasal neurostimulation device for dry eye it bought last year.
Oculeve is a hand-held device designed to be inserted into the nostril to stimulate the nerves serving the lacrimal gland. Allergan paid $125 million plus unspecified milestones for Oculeve last year.
Today the company said a pair of pivotal trials passed their safety and efficacy endpoints, clearing the way for a pre-market approval submission in the 2nd half of the year.
The 48-patient OCUN-009 trial evaluated intra- and extra-nasal use of the Oculev...
Source: Mass Device - May 16, 2016 Category: Medical Equipment Authors: Brad Perriello Tags: Clinical Trials Food & Drug Administration (FDA) Optical/Ophthalmic Regulatory/Compliance Allergan Inc. Oculeve Source Type: news
Cyclosporine Capsules (New - Discontinuation)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 11, 2016 Category: Drugs & Pharmacology Source Type: news
Allergan Receives Complete Response Letter from FDA for Prior Approval Supplement for RESTASIS(R) (Cyclosporine Ophthalmic Emulsion) 0.05% Multi-Dose Preservative-Free Bottle
DUBLIN, March 10, 2016 -- (Healthcare Sales & Marketing Network) -- Allergan plc (AGN) announced today it has received a Complete Response Letter from the U.S. Food and Drug Administration (FDA) for its Prior Approval Supplement (PAS) for RESTASIS® (C... Biopharmaceuticals, Ophthalmology, FDAAllergan, RESTASIS, Cyclosporine, Chronic Dry Eye (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 10, 2016 Category: Pharmaceuticals Source Type: news
Infliximab May Top Cyclosporine for Steroid-Refractory Ulcerative ColitisInfliximab May Top Cyclosporine for Steroid-Refractory Ulcerative Colitis
Infliximab may be slightly better than cyclosporine for treating patients with steroid-refractory ulcerative colitis (UC), according to results from a systematic review and meta-analysis. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - March 1, 2016 Category: Gastroenterology Tags: Gastroenterology News Source Type: news
Nulojix Ups Survival in Kidney Transplant Patient (CME/CE)
(MedPage Today) -- Long-term risk of death, graft loss lower than with cyclosporine (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - January 27, 2016 Category: Surgery Source Type: news
Cyclosporine A Flops for PCI Cardioprotection (CME/CE)
(MedPage Today) -- Pharmacological post-conditioning suffers a blow (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 25, 2016 Category: Cardiology Source Type: news
HIV-1 Capsid Stabilization Assay
The stability of the HIV-1 core in the cytoplasm is crucial for productive HIV-1 infection. Mutations that stabilize or destabilize the core showed defects in HIV-1 reverse transcription and infection. We developed a novel and simple assay to measure stability of in vitro-assembled HIV-1 CA-NC complexes. This assay allowed us to demonstrate that cytosolic extracts strongly stabilize the HIV-1 core (Fricke et al., J Virol 87:10587–10597, 2013). By using our novel assay, one can measure the ability of different drugs to modulate the stability of in vitro-assembled HIV-1 CA-NC complexes, such as PF74, CAP-1, IXN-053, cy...
Source: Springer protocols feed by Immunology - December 7, 2015 Category: Allergy & Immunology Source Type: news
Scientists identify potential birth control 'pill' for men
Two drugs that help suppress the immune system in organ transplant patients may have a future as the long-sought birth control "pill" for men, new research suggests. The drugs – cyclosporine A (also known as CsA) and FK506 (also known as tacrolimus) – are given to transplant recipients to reduce... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - October 1, 2015 Category: Science Authors: Karen Kaplan Source Type: news
The Cardiology Show From ESC 2015 with Dr Valentin FusterThe Cardiology Show From ESC 2015 with Dr Valentin Fuster
The panel discuss a leadless pacemaker, cyclosporine and reperfusion injury, hypertension treatments, high-sensitivity troponin for early MI diagnosis, and yet more data on antithrombins for PCI. theheart.org on Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - September 2, 2015 Category: Cardiology Tags: Cardiology Roundtable Source Type: news
News from the European Society of Cardiology Conference (FREE)
By the Editors
Here's a quick look at some of the major news that came out of the European Society of Cardiology Congress in London this weekend:Cyclosporine Before Percutaneous Coronary Intervention? Among patients with acute anterior … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 31, 2015 Category: Primary Care Source Type: news
CIRCUS: No Cyclosporine Benefit in STEMI PCI Setting CIRCUS: No Cyclosporine Benefit in STEMI PCI Setting
Hopeful that cyclosporine could limit myocardial reperfusion injury, as shown in small studies and animal models, CIRCUS investigators failed to show an improvement in hard clinical outcomes following PCI for STEMI. Heartwire from Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - August 30, 2015 Category: Cardiology Tags: Cardiology News Source Type: news
