Infliximab May Top Cyclosporine for Steroid-Refractory Ulcerative ColitisInfliximab May Top Cyclosporine for Steroid-Refractory Ulcerative Colitis

Infliximab may be slightly better than cyclosporine for treating patients with steroid-refractory ulcerative colitis (UC), according to results from a systematic review and meta-analysis. Reuters Health Information
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology News Source Type: news

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This study aimed to investigate the specific regulatory roles of microRNA-219-5p (miR-219-5p) on ulcerative colitis (UC), and reveal the potential mechanisms relating with the differentiation of Treg/Th17 cells. Methods: The mouse model of chronic UC was established by oral administration of 3% dextran sodium sulfate for three cycles. After intravenous injected with lentivirus (LV)-miR-219-5p for 24 h, the disease activity index (DAI), colon length, as well as the serum levels of Interleukin (IL)-6, -17A, -21, and -23 were measured. In addition, the histopathological changes in colon tissues were observed by Hematoxylin...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
We report the case of a 9-year-old female patient affected by ulcerative colitis and recently treated for an oral candidiasis, who experienced a relapse in her ulcerative colitis (PUCAI 50), preceded by the return of whitish lesions in the oral cavity, initially misdiagnosed and unsuccessfully treated as candidiasis and then recognized as pyostomatitis vegetans. Bloody diarrhea was treated with oral beclomethasone, with rapid remission of ulcerative colitis and disappearance of pyostomatitis vegetans. After 2 years, ulcerative colitis is in sustained remission with oral mesalamine and pyostomatitis vegetans has not recurre...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Case Report Source Type: research
Publication date: Available online 2 June 2020Source: Food ChemistryAuthor(s): Ruifeng Luo, Meisi Lin, Chen Zhang, Jinfeng Shi, Siyuan Zhang, Qiyan Chen, Yichen Hu, Minyue Zhang, Jinming Zhang, Fei Gao
Source: Food Chemistry - Category: Food Science Source Type: research
In this study, we further explored the effect of sucralose on tumorigenesis and the possible mechanism involved using the AOM/DSS mouse model. First, 1.5 mg/ml sucralose was included in the drinking water for 6 weeks to reach a relatively stable phase of impact on gut microbiota. Then, 10 mg/kg AOM was administered through intraperitoneal injection. Seven days later, 2.5% DSS was put in the drinking water for 5 days, followed by 2 weeks without DSS. The 5 days of DSS was then repeated, and the mice were sacrificed 6 weeks after AOM injection. The results showed that sucralose caused significant increases in the number and ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
DiscussionOn April 30, 2014, the World Health Organization published an alarming report on antibiotic resistance. Finding an alternative medical treatment to antibiotics in order to prevent relapses of pouchitis is therefore becoming increasingly important given the risk posed by multiresistant bacteria. Moreover, if the results of this study are conclusive, FMT, which is less expensive than biologics, could become a routine treatment in the future.Trial registrationClinicalTrials.gov,NCT03524352. Registered on 14 May 2018.
Source: Trials - Category: Research Source Type: clinical trials
AbstractObjectivesPrimary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure.Secondary objectives:To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial.To evaluate the duration of COVID-19 symptoms in participants receiving melatonin before the infection...
Source: Trials - Category: Research Source Type: clinical trials
Conditions:   Inflammatory Bowel Diseases;   COVID Intervention:   Sponsor:   Hull University Teaching Hospitals NHS Trust Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Fatemeh Adiliaghdam ; Sreehaas Digumarthi ; Lai P Wong ; Ruslan Sadreyev ; Kate L JeffreySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeripheral blood-derived macrophages were stimulated with viral-like particles isolated from colonic resections from patients with Crohn's disease (CD), ulcerative colitis (UC), or non-IBD controls diagnoses. RNAseq was performed to unbiasedly assess the transcriptional responses to these stimuli and revealed highly divergent macrophage transcriptional programs in response to non-IBD compared to IBD VLP.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Endoscopic assessment of disease activity is an essential part of clinical practice in inflammatory bowel disease (IBD) and is used for diagnosis, prognosis, monitoring for dysplasia and increasingly for the evaluation of mucosal or endoscopic response to therapy. Recently, endoscopic healing has emerged as a key goal of therapy However there are numerous endoscopic scoring systems proposed to define endoscopic activity and response to therapy in both ulcerative colitis and Crohns disease. The routine use of endoscopic scoring systems is currently limited to trial settings.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
Endoscopic mucosal healing is an important therapeutic goal in the management of ulcerative colitis (UC). However, some patients clinically relapse in the short term despite endoscopic mucosal healing was achieved. Recently, it has been reported that the histological mucin depletion was an independent clinically relapse factor of patients with an Mayo endoscopic score (MES) of 0.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
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