TWiV 751: Sputnik spat and furin in ferrets
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaleya vaccine (Sci Transl Med) Russian vaccine behavior (Sci Transl Med) Is Gamaleya vaccine safe? (Science) Furin cleavage site ...
Source: This Week in Virology - MP3 Edition - May 6, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 750: To err is viral
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine education town halls (ASV) RSV cpDVG may influence clinical outcome (Nat Micro) Henipa- and filo-like viruses in Trinidad bats (J Inf Dis) Nice image of cpDVG generation Letters read on TWiV 750 Timesta...
Source: This Week in Virology - MP3 Edition - May 2, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 740: Complementation will get you everywhere
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here) Research position in Spindler laboratory Attenuation of poliovirus...
Source: This Week in Virology - MP3 Edition - April 8, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Arturo Casadevall Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Victory for Scientific Pragmatism (New Atlantis) Convalescent plasma levels and risk of COVID-19 death (NEJM) COVID-19 convalescent plasma safety ...
Source: This Week in Virology - MP3 Edition - April 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Noninvasive Ventilation of COVID-19 Patients
Noninvasive ventilation (NIV) may help COVID-19 patients in respiratory failure avoid invasive mechanical ventilation but may also lead to delays in intubation with potential for worse clinical outcomes. Domenico L. Grieco, MD, of Fondazione Policlinico Agostino Gemelli IRCCS in Rome, Jesse B. Hall, MD, of the University of Chicago, and Laveena Munshi, MD, MSc, of Sinai Health System/University Health Network of the University of Toronto join JAMA's live Q&A series to discuss helmet NIV, high-flow nasal oxygen, and other NIV modalities in the management of hypoxic coronavirus patients. Recorded March 25, 2021. Related Cont...
Source: JAMA Author Interviews - March 29, 2021 Category: General Medicine Authors: JAMA Network Source Type: podcasts
Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD
Nancy E. Messonnier, MD is director of the National Center for Immunization and Respiratory Diseases (NCIRD) at the Centers for Disease Control and Prevention (CDC) and leads the CDC’s efforts on COVID-19 vaccination. She joins JAMA's Q&A series to discuss the agency's response to emerging coronavirus variants, the FDA advisory hearings on the new Johnson & Johnson vaccine, and other agency activities and priorities related to COVID-19 control. Recorded February 26, 2021. Related Content: Genetic Variants of SARS-CoV-2—What Do They Mean? Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD SARS-CoV-2 V...
Source: JAMA Author Interviews - March 2, 2021 Category: General Medicine Authors: JAMA Network Source Type: podcasts
Coronapod: The big COVID research papers of 2020
Benjamin Thompson, Noah Baker and Traci Watson discuss some of 2020's most significant coronavirus research papers.In the final Coronapod of 2020, we dive into the scientific literature to reflect on the COVID-19 pandemic. Researchers have discovered so much about SARS-CoV-2 – information that has been vital for public health responses and the rapid development of effective vaccines. But we also look forward to 2021, and the critical questions that remain to be answered about the pandemic.Papers discussedA Novel Coronavirus from Patients with Pneumonia in China, 2019 - New England Journal of Medicine, 24 JanuaryClinical ...
Source: Nature Podcast - December 17, 2020 Category: Science Authors: Springer Nature Limited Source Type: podcasts
SCCM Pod-428 Endotracheal Tube Size and Aspiration
Each year, approximately 790,000 patients in the United States develop acute respiratory failure that requires intubation and mechanical ventilation. (Source: SCCM PodCast - iCritical Care)
Source: SCCM PodCast - iCritical Care - November 19, 2020 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts
TWiV 673: Wake up and smell the pandemic
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 testing strategy calculator (and medRxiv preprint) US COVID-19 mortality rates (JAMA) Final remdesivir report (NEJM) Hydroxychloroquine for COVID-19 (NEJM) Te...
Source: This Week in Virology - MP3 Edition - October 18, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
SCCM Pod-424 Critical Care Implications of Respiratory Depression on Hospital Wards
Continuous monitoring on hospital wards can prevent adverse events and unnecessary ICU admissions. (Source: SCCM PodCast - iCritical Care)
Source: SCCM PodCast - iCritical Care - October 8, 2020 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts
'Flu vaccine season - with Nikki Turner and Jeff Kwong
With the annual flu season looming, GPs are anticipating a frenzy of vaccinations, perhaps more so than ever this year.
As so many 'flu and respiratory viruses circulate every year, and as the 'flu vaccine is for one strain of influenza only, is the vaccine worth getting, and what are the risks associated with vaccinating vs. not vaccinating?
In this week’s episode, we discuss the high vaccine uptake in New Zea land, and the role that social distancing for COVID-19 may have played in their low numbers of seasonal flu.
We also talk about whether or not the message we give to patients about the benefits and risks of ...
Source: The BMJ Podcast - September 24, 2020 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
